Özgün PALAK, Cahit CANBAY, Aydoğa KALLEM

Investigating the occurrence mechanism of cytokine-like formations by the electromagnetic approach

This study aims to elucidate the production mechanism of cytokine-like formations secreted from T cells andsimilar cells by electromagnetic modeling techniques. Three Hertz dipole antennas polarized in arbitrary directions wereplaced without touching each other at the center of spherical T-cell models to test the Canbay hypothesis about theformation mechanism of cytokines (CHAFMOC) on T-cell surfaces. A dielectrophoretic force field was created withinthe gelatin layer of the T-cell model. The prepared control and electromagnetically stimulated T-cell model sampleswere incubated in water in a glass container in a Faraday cage for the specified period and then photographed. At theend of the experiments, cytokine-like formations were observed in the samples, depending on their contents. The resultsof these experiments, carried out in accordance with the CHAFMOC, show that a dielectrophoretic force is the maincause of the cytokine formation and secretion mechanism in the outer layers of rough T-cell models. Given these results,new approaches and developments may be expected to better our understanding of the immune system in the subjectsof cell science, pharmacology, and bioengineering.

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