A novel design of an electromagnetically levitated vibrational viscometer for biomedical and clinical applications

A novel design of an electromagnetically levitated vibrational viscometer for biomedical and clinical applications

Accurate determination of the viscosity behavior of fluids is extremely important, especially for biomedicaland clinical applications. For example, blood viscosity is used to detect cardiovascular diseases in patients. Like blood, all body fluids and biochemical solvents used in biomedical studies are very limited resources. Therefore, a viscometer that is especially focused for biomedical and clinical applications should have the ability to obtain viscosity results from a reservoir as small as possible, in a range as wide as possible and in a period of time as short as possible. The measurements must be accurate even when the fluid temperatures shift swiftly and the test fluids pass throughout the viscometer continuously. Thus, it would be a huge advantage if a viscometer had the capability to measure simultaneously dynamic viscosity, kinematic viscosity, static viscosity, and density. However, there is no viscometer in the world that can achieve these goals. In this study, a novel electromagnetically levitated vibrational viscometer is designed to solve this problem.

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  • [1] Lowe GDO, Lee AJ, Rumley A, Price JF, Fowkes FGR. Blood viscosity and risk of cardiovascular events: the Edinburgh Artery Study. Br J Haematol 1997; 96: 168-173.
  • [2] Devereux RB, Drayer JI, Chien S, Pickering TG, Letcher RL, DeYoung JL, Sealey JE, Laragh JH. Whole blood viscosity as a determinant of cardiac hypertrophy in systemic hypertension. Am J Cardiol 1984; 54: 592-595.
  • [3] Raine AEG. Hypertension, blood viscosity, and cardiovascular morbidity in renal failure: implications of erythropoietin therapy. Lancet 1988; 331: 97-100.
  • [4] de Simone G, Devereux RB, Chien S, Alderman MH, Atlas SA, Laragh JH. Relation of blood viscosity to demographic and physiologic variables and to cardiovascular risk factors in apparently normal adults. Circulation 1990; 81: 107-117.
  • [5] Letcher RL, Chien S, Pickering TG, Sealey JE, Laragh JH. Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects: role of fibrinogen and concentration. Am J Med 1981; 70: 1195-1202.
  • [6] Muizelaar JP, Wei EP, Kontos HA, Becker DP. Cerebral blood flow is regulated by changes in blood pressure and in blood viscosity alike. Stroke 1986; 17: 44-48.
  • [7] Hunter RL, Papadea C, Gallagher CJ, Finlayson DC, Check IJ. Increased whole blood viscosity during coronary artery bypass surgery. Thromb Haemost 1990; 63: 006-012.
  • [8] Dormandy JA. Clinical significance of blood viscosity. Ann R Coll Surg Engl 1970; 47: 211.
  • [9] Yetkin F, Kayabas U, Ersoy Y, Bayindir Y, Toplu SA, Tek I. Cerebrospinal fluid viscosity: a novel diagnostic measure for acute meningitis. South Med J 2010; 103: 892-895.
  • [10] Chang LC, Hua CC, Liu YC, Chu CM, Chen HJ, Lee N. Pleural fluid viscosity may help identifying malignant pleural effusions. Respirology 2008; 13: 341-345.
  • [11] Inman BA, Etienne W, Rubin R, Owusu RA, Oliveira TR, Rodriques DB, Dewhirst MW. The impact of temperature and urinary constituents on urine viscosity and its relevance to bladder hyperthermia treatment. Int J Hypertherm 2013; 29: 206-210.
  • [12] Gassmann HU, Mugnier M. U.S. Patent No. 3,699,804. Washington DC, USA: U.S. Patent and Trademark Office, 1972.
  • [13] Tzentis LS. U.S. Patent No. 3,435,665. Washington DC, USA: U.S. Patent and Trademark Office, 1969.
  • [14] Bryan WL, Bryan JM. U.S. Patent No. 5,203,203. Washington DC, USA: U.S. Patent and Trademark Office, 1993.
  • [15] Park NA. U.S. Patent No. 5,327,778. Washington DC, USA: U.S. Patent and Trademark Office, 1994.
  • [16] Ball JM. U.S. Patent No. 4,750,351. Washington DC, USA: U.S. Patent and Trademark Office, 1988.
  • [17] Bryan WL, Bryan JM. U.S. Patent No. 5,203,203. Washington DC, USA: U.S. Patent and Trademark Office, 1993
  • [18] Ibar JP. U.S. Patent No. 5,885,495. Washington DC, USA: U.S. Patent and Trademark Office, 1999.
  • [19] Dealy JM. Challenges in process rheometry. Rheol Acta 1990; 29: 519-522.
  • [20] Ross RA, Kauzlarich JJ. U.S. Patent No. 5,710,374. Washington DC, USA: U.S. Patent and Trademark Office, 1998
  • [21] Cohen-Tenoudji F, Ahlberg LA, Tittmann BR, Pardee WJ. U.S. Patent No. 4,779,452. Washington DC, USA: U.S. Patent and Trademark Office, 1988.
  • [22] Palmer AA. U.S. Patent No. 4,045,999. Washington DC, USA: U.S. Patent and Trademark Office, 1977.
  • [23] Boyle FP, Garvin G, Damm KW, Heath DH, George HF, Moore PJ, Robinson TE. U.S. Patent No. 6,412,338. Washington DC, USA: U.S. Patent and Trademark Office, 2002.
  • [24] Sakai K, Hirano T, Hosoda M. Electromagnetically spinning sphere viscometer. Appl Phys Express 2010; 3: 016602.
  • [25] Stabinger H, Leopold H. U.S. Patent No. 5,477,726. Washington DC, USA: U.S. Patent and Trademark Office, 1995.
  • [26] Plungis DW, Seymour CS, Higgins W. U.S. Patent No. 4,616,503. Washington DC, USA: U.S. Patent and Trademark Office, 1986
  • [27] Baek SG. U.S. Patent No. 7,290,441. Washington DC, USA: U.S. Patent and Trademark Office, 2007.
  • [28] Baek SG. U.S. Patent No. 7,770,436. Washington DC, USA: U.S. Patent and Trademark Office, 2007.
  • [29] Akpek A, Youn C, Kagawa T. A study on vibrational viscometers considering temperature distribution effect. JFPS Int J Fluid Power System 2014; 7: 1-8.
  • [30] Akpek A, Youn C, Maeda A, Fujisawa N, Kagawa T. Effect of thermal convection on viscosity measurement in vibrational viscometer. Journal of Flow Control, Measurement & Visualization 2014; 2: 12.
  • [31] Akpek A, Youn C, Kagawa T. Temperature measurement control problem of vibrational viscometers considering heat generation and heat transfer effect of oscillators. 2013 9th Asian Control Conference (ASCC), Istanbul, 2013, pp. 1-6.
  • [32] Akpek A. Effect of non-uniform temperature field in viscosity measurement. J Vis 2016; 19: 291-299.
  • [33] Kiuchi M, Fujisawa N, Tomimatsu S. Performance of PIV system for combusting flow and its application to spray combustor model. J Vis 2005; 8: 269-276.
  • [34] Akpek A. Development of a heart assist device as a vibrational viscometer that estimates blood viscosity. Journal of the Faculty of Engineering & Architecture of Gazi University 2018; 2018: 1-15 (article in Turkish with an abstract in English).
  • [35] Holman JP, Heat Transfer. 8th ed. New York, NY, USA: McGraw-Hill, 2001.
  • [36] Gupta S, Wang WS, Vanapalli SA. Microfluidic viscometers for shear rheology of complex fluids and biofluids. Biomicrofluidics 2016; 10: 043402.
  • [37] Ong PK, Lim D, Kim S. Are microfluidics-based blood viscometers ready for point-of-care applications? A review. Crit Rev Biomed Eng 2010; 38: 189-200.
  • [38] Heinisch M, Reichel EK, Dufour I, Jakoby B. Miniaturized resonating viscometers facilitating measurements at tunable frequencies in the low kHz-range. Procedia Eng 2011; 25: 639-642.
  • [39] Desroques E, Godefroy SN, Goodwin ARH, Harrison C, Hsu K, Matsumoto N. U.S. Patent No. 8,166,812. Washington DC, USA: U.S. Patent and Trademark Office, 2012.
  • [40] Raut SL, Kimball JD, Fudala R, Bora I, Chib R, Jaafari H, Gryczynski Z. A triazine-based BODIPY trimer as a molecular viscometer. Phys Chem Chem Phys 2016; 18: 4535-4540.
Turkish Journal of Electrical Engineering and Computer Sciences-Cover
  • ISSN: 1300-0632
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK