Naim Boran TÜMER, Erkan İRİZ, Özlem GÜLBAHAR, Dilek ERER, Halim SONCUL, Elif COŞKUN

Varis etiyopatogenezinde lökosit aktivasyonu ile apopitozisin ilişkisi

Amaç: Variköz venler alt ekstremite en sık görülen rahatsızlıklarıdır. Bu çalışmanın amacı, lökosit aktivasyonunun ven duvarındaki apoptozis ve variköz venlerin patogenezindeki etkisini araştırmaktır.Gereç ve Yöntemler: Çalışmaya variköz venleriolan 46 hasta dahil edildi. Hastalara semptomları, komplikasyonları veya kozmetik sebeplerle strippingle yüksek ligasyon, ve eksizyon yapıldı. Serum kaspaz-8 ve kaspaz-9 ölçümüleri ELİSA kullanılarak yapıldı.Bulgular: Sağlıklı sefalik ven ile variköz safen ven gruplarının sonuçları arasında istatistiksel olarak anlamlı bir fark tespit edildi (p=0.04 and p<0.0001). Sonuç: Variköz ven oluşumunun altındaki karmaşık patofizyoloji henüz yeterince açıklanamamıştır. Hem lökosit aktivasyonunun hemde apopitozisdeki bozulmanın variköz ven oluşumuna katkısı olduğunu düşünmekteyiz.

Anahtar Kelimeler:

venöz yetmezlik, lökosit aktivasyonu, kaspaz, apopitozis

The relationship between leukocyte activation and apoptosis in venous insufficiency etiopathogenesis

Aim: Varicose veins are the most common disorders of the lower extremities. The purpose of this study is to investigate the effect of leukocyte activation in the vein wall and apoptosis in the etiopathogenesis of varicose veins.Material and Methods:Forty-six patients with varicose veins were included in the study. High ligation with stripping with or without additional individual ligation and excision was performed for symptoms, complications or cosmetic needs. ELISA was used to measure the serum concentration of caspase-8 and caspase-9.Results: There was a statistically significant difference between the cephalic vein and saphenous vein groups (p=0.04 and p<0.0001 respectively). Conclusion: As a conclusion, the complex pathophysiology underlying varicose veins has yet to be fully defined. It is suggested that both leukocyte activation and dysregulation of apoptosis are associated with susceptibility for varicose vein formation however this argument needs further research.

Keywords:

Apoptosis, Venous Insufficiency, caspas, leukocyte,

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