Platelet lenfosit oranı ve hipertansiyonun diürnal ritmi arasındaki ilişki

Amaç: Platelet lenfosit oranı (PLR) kardiyovasküler kötü sonlanımlar için öngördürücüdür. Ancak PLR’nın hipertansiyonun diürnal ritmindeki rolü ile ilgili veri sınırlıdır. Biz bu çalışmada PLR ile hipertansiyonun diürnal ritmi arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çalışmaya toplamda 247 esansiyel hipertansiyon hastası dahil edildi. Tüm hastalara 24-saat ambulatuar kan basıncı monitorizasyonu yapıldı. Takiben hastalar iki gruba ayrıldı: 64 dipper hasta (30 kadın, ortalama yaş 53.8±12.9) ve 38 non-dipper hasta (18 kadın, ortalama yaş 52.6±12.5). Tam kan sayımı ve biyokimyasl değerlendirme standart metodlarla yapıldı. PLR platelet sayısının lenfosit sayısına bölünmesiyle hesaplandı. Bulgular: Nondipper hipertansifler dipper hipertansiflere kıyasla daha yüksek PLR’ye sahipti (127.9±32.16’e 103.4±10.67, p<0.001). Sistolik ve diastolik kan basıncının düşüş oranı ile PLR arasında negatif korelasyon mevcuttu. Sonuç: Ucuz ve kolay ulaşılabilir bir biobelirteç olan PLR, nondipper hipertansiflerde dipper hipertansiflere kyasla daha yüksektir.

Anahtar Kelimeler:

Hipertansiyon, non-dipper, dipper, platelet lenfosit oranı

The relationship between platelet to lymphocyte ratio and the diurnal variation of hypertension

Aim: Platelet to lymphocyte ratio (PLR) predicts worse outcome in cardiovascular disease. However data is limitted about the role of PLR in the diurnal variation of hypertension. In this study we evaluated the relationship between the diurnal variation of hypertension and PLR. Material and Methods: The study included a total of 247 essential hypertensive patients. All patients underwent 24-hour ambulatory blood monitoring. Thereafter hypertensive patients were divided into two groups: 64 dipper patients (30 female, mean age 53.8±12.9 years) and 38 non-dipper patients (18 female, mean age 52.6±12.5years). Complete blood count and biochemistry were measured by standard methods. PLR was measured by dividing platelet count to lymphocyte count.Results: Non-dipper hypertensives had signifi cantly higher PLR levels than dippers (127.9±32.16 vs 103.4±10.67, p<0.001). There was a negatif correlation between percentage of sistolic and diastolic blood pressure fall and PLR. Conclusion: We demonstrated that PLR, an inexpensive and easily accessible biomarker, is significantly higher in nondipper hypertensives than the dipper hypertensives.

Keywords:

Hypertension, non-dipper, dipper, platelet to lymphocyte ratio,

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