Bahar TEKİN TAK, Serkan ÇAY, Mahmut YÜKSEL, Firdevs Ayşenur EKİZLER, Habibe KAFES, Meral Akdoğan KAYHAN, Çağrı YAYLA, Ertuğrul KAYAÇETİN

Nonalkolik yağlı karaciğer hastalığı olan bireylerde Tp-e intervali ve Tp-e/qt oranı

Giriş: Elektrokardiyografide (EKG) ventriküler repolarizasyon Tp-e intervali ve kalp hızına göre düzeltilmiş QT (QTc) aralığı kullanılarak değerlendirilir. Uzamış Tp-e/QTc oranı aritmiler ve kardiyak mortalite riskinde artışla ilişkilidir. NASH (nonalkolik steatohepatit)’ in ventriküler repolarizasyon üzerine etkileriyle ilgili az sayıda çalışma olduğu için, NASH hastalarında Tp-e interval ölçümlerini ve Tp-e/QT oranını değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çalışmamıza toplam 97 NASH hastası ile 77 kişilik kontrol grubu dahil edildi. Tp-e intervali, Tp-e/QT ve Tp-e/QTc oranları 12-lead elektrokardiyogram ile ölçüldü. Bulgular: Kalp hızı her iki grupta da benzerdi (74.8 ± 10.1 vs. 75.7 ± 11.7; p=0.598). QT interval (396.0 ± 34.2 vs. 384.6 ± 30.7; p=0.023) ve QTc interval (403.6 ± 34.8 vs. 399.9 ± 36.3; p=0.027), Tp-e interval (100.4 ± 13.6 vs. 91.4 ± 13.4; p<0.001) , Tp-e/QT oranı (0.25 ± 0.03 vs. 0.23 ± 0.03; p=0.003) ve Tp-e/QTc oranı (0.23 ± 0.03 vs. 0.21 ± 0.03; p=0.002), gruplararası anlamlı olarak farklı saptandı. Tp-e interval (r= 0.328, p<0.001) ve Tp-e/QTc oranı ile hepatik steatoz derecesi (r= 0.237, p=0.002) arasında anlamlı bir ilişki mevcuttu. Sonuç: NASH hastalarında Tp-e interval, QT interval, QTc interval, Tp-e/QT ve Tp-e/QTc oranları uzamıştı. NASH ‘in artmış Tp-e/QT oranı için bağımsız bir faktör olduğu bulundu. Bu çalışma NASH hastalarında Tp-e intervali ve Tp-e/QT parametrelerinin araştırıldığı ilk çalışmadır.

Anahtar Kelimeler:

Tp-e intervali, Tp-e/QTc oranı, ventirküler repolarizasyon, NASH

Tp-e interval and Tp-e/qt ratio in patients with non alcoholic fatty liver disease

Aim: Ventricular repolarization is assessed using the Tp-e interval and QT interval corrected by the heart rate (QTc) via an electrocardiogram (ECG). Prolonged Tp-e/QTc is related with an increased risk of arrhythmias and cardiac mortality. As there have been few reports regarding the effects of NAFLD on ventricular repolarization, we aimed to appraise the assessment of Tp-e interval and Tp-e/QT ratio in patients with NAFLD. Material and Methods: Totally 97 patients with NAFLD and 77 control subjects were enrolled in our study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were measured from the 12-lead electrocardiogram. Results: Heart rate was similar between groups (74.8 ± 10.1 vs. 75.7 ± 11.7; p=0.598). QT interval (396.0 ± 34.2 vs. 384.6 ± 30.7; p=0.023) and QTc interval (403.6 ± 34.8 vs. 399.9 ± 36.3; p=0.027), Tp-e interval (100.4 ± 13.6 vs. 91.4 ± 13.4; p<0.001) , Tp-e/QT ratio (0.25 ± 0.03 vs. 0.23 ± 0.03; p=0.003) and Tp-e/QTc ratio (0.23 ± 0.03 vs. 0.21 ± 0.03; p=0.002) were significantly different between groups. There was significant correlation between Tp-e interval (r= 0.328, p<0.001) and Tp-e/QTc ratio and hepatic steatosis grade (r= 0.237, p=0.002). Conclusion: Tp-e interval, QT interval, QTc interval, Tp-e/QT and Tp-e/QTc ratios were prolonged in patients with NAFLD. NAFLD is found an independent factor for increased Tp-e/QT ratio. This is the first study that investigated the Tp-e interval and Tp-e/QT parameters in patients with NAFLD.

Keywords:

NAFLD, Tp-e interval, Tp-e/QTc ratio, ventricular repolarization,

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