Mariola BRYCHT, Radovan METELKA, Sylwia SMARZEWSKA, Natalia FESTINGER, Monika SKOWRON, Witold CIESIELSKI, Dariusz GUZIEJEWSKI

Voltammetric analysis of disulfiram in pharmaceuticals with a cyclic renewable silver amalgam film electrode

Electrochemical properties of disulfiram, representative of highly significant bioactive compounds, were studied with a cyclic renewable silver amalgam film electrode (Hg(Ag)FE) using square wave cathodic stripping voltammetry (SWCSV). The influence of various factors such as pH, buffer concentration, buffer composition, and SWCSV parameters on current response was investigated. The optimum results in terms of signal shape and intensity were recorded in Britton Robinson buffer (pH 7.5) at 0.5 V versus Ag/AgCl/3 mol L −1 KCl. An elaborated electroanalytical procedure was used to determine disulfiram at the Hg(Ag)FE in the concentration range from 0.05 to 5.00 µM. Precision, repeatability, and accuracy of the method as well as the influence of possible interferences were ascertained. The detection and quantification limits were 11 nM and 37 nM, respectively. The applicability of the developed method was tested in the determination of disulfiram in the commercial formulation Anticol. Thin-layer chromatography with image processing software was used to validate the accuracy of the method.

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1. Kukoc-Modun, L.; Tsikas, D.; Biocic, M.; Radi´c, N. Anal. Lett. 2016, 49, 607-617.
2. Nigovic, B.; Marusic, M.; Juric, S. J. Electroanal. Chem. 2011, 663, 72-78.
3. Smarzewska, S.; Pokora, J.; Leniart, A.; Festinger, N.; Ciesielski, W. Electroanalysis 2016, 28, 1562-1569.
4. Tumpa, A.; Miladinovi´c, T.; Raki´c, T.; Staji´c, A.; Janˇci´c-Stojanovi´c, B. Anal. Lett. 2016, 49, 445-457.
5. Wudarska, E.; Chrzescijanska, E.; Kusmierek, E.; Rynkowski, J. Int. J. Electrochem. Sci. 2015, 10, 9433-9442.
6. Hald, J.; Jacobsen, E. Lancet 1948, 252, 1001-1004.
7. Suh, J. J.; Pettinati, H. M.; Kampman, K. M.; OBrien, C. P. J. Clin. Psychopharmacol. 2006, 26, 290-302.
8. Ishikawa, M.; Aoki, T.; Yomogida, S.; Takayanagi, Y.; Sasaki, K. Pharmacol. Toxicol. 1994, 74, 255-261.
9. OBrien, A.; Barber, J. E.; Reid, S.; Niknejad, N.; Dimitroulakos, J. Anticancer Res. 2012, 32, 2679-2688.
10. Sauna, Z. E.; Shukla, S.; Ambudkar, S. V. Mol. BioSyst. 2005, 1, 127-134.
11. Agui, L.; Pena, L.; Pedrero, M.; Yanez-Sedeno, P.; Pingarron, J. M. Electroanalysis 2002, 14, 486-492.
12. Tomcik, P.; Krajcikova, M.; Bustin, D. Talanta 2001, 55, 1065-1070.
13. Fernandez, C.; Reviejo, A. J.; Pingarron, J. M. Analusis 1995, 23, 319-324.
14. Fernandez, C.; Reviejo, A. J.; Pingarron, J. M. Anal. Chim. Acta 1995, 305, 192-199.
15. Zakharova, O. M.; Zakharov, M. S. J. Anal. Chem. 2002, 57, 717-720.
16. Prue, D. G.; Warner, C. R.; Kho, B. T. J. Pharm. Sci. 1972, 61, 249-251.
17. Mairesse-Ducarmois, C. A.; Patriarche, G. J.; Vandenbalck, J. L. Anal. Chim. Acta 1976, 84, 47-52.
18. Saracino, M.A.; Marcheselli, C.; Somaini, L.; Gerra, G.; De Stefano, F.; Pieri, M. C.; Raggi, M. A. Anal. Bioanal. Chem. 2010, 398, 2155-2161.
19. Smith, R. M.; Morarji, R. L.; Salt, W. G. Analyst 1981, 106, 129-134.
20. Fernandez, C.; Reviejo, A. J.; Polo, L. M.; Pingarron, J. M. Talanta 1996, 43, 1341-1348.
21. Mourya, S. K.; Dubey, S.; Durgabanshi, A.; Shukla, S. K.; Esteve-Romero, J.; Bose, D. J. AOAC Int. 2011, 94, 1082-1088.
22. Irth, H.; de Jong, G. J.; Brinkman, U. A.; Frei, R. W. J. Chromatogr. 1988, 424, 95-102.
23. Masso, P. D.; Kramer, P. A. J. Chromatogr. B 1981, 224, 457-464.
24. Johansson, B. J. Chromatogr. 1986, 378, 419-429.
25. Jensen, J. C.; Faiman, M. D. J. Chromatogr. 1980, 181, 407-416.
26. Blasco, C.; Font, G.; Pic´o, Y. J. Chromatogr. A 2004, 1028, 267-276.
27. Zhang, L.; Jiang, Y.; Jing, G.; Tang, Y.; Chen, X.; Yang, D.; Zhang, Y.; Tang, X. J. Chromatogr. B 2013, 937, 54-59.
28. Johansson, B. Clin. Chim. Acta 1988, 177, 55-63.
29. Cobby, J.; Mayersohn, M.; Selliah, S. J. Pharmacol. Exp. Therap. 1977, 202, 724-731.
30. Skowron, M.; Ciesielski, W. J. Anal. Chem. 2011, 66, 714-719.
31. Tompsett, S. L. Acta Pharmacol. Toxicol. 1964, 21, 20-22.
32. Ba´s, B. Polish Patent No. P-319984, 1997.
33. Ba´s, B.; Kowalski, Z. Electroanalysis 2002, 14, 1067-1071.
34. Ba´s, B. Electrochem. Commun. 2008, 10, 156-160.
35. Bobrowski, A.; Gawlicki, M.; Kapturski, P.; Mirceski, V.; Spasovski, F.; Zar¸ebski, J. Electroanalysis 2009, 21, 36-40.
36. Piech, R.; Ba´s, B.; Paczosa-Bator, B.; Kubiak, W. W. J. Electroanal. Chem. 2009, 633, 333-338.
37. Kapturski, P.; Bobrowski, A. J. Electroanal. Chem. 2008, 617, 1-6.
38. Piech, R.; Ba´s, B.; Kubiak, W. W. J. Electroanal. Chem. 2008, 621, 43- 48.
39. Piech, R.; Ba´s, B.; Kubiak, W. W. Talanta 2008, 76, 295-300.
40. Ba´s, B. Anal. Chim. Acta 2006, 570, 195-201.
41. Piech, R.; Ba´s, B.; Kubiak, W. W. Electroanalysis 2007, 19, 2342-2350.
42. Guziejewski, D.; Brycht, M.; Nosal-Wierci´nska, A.; Smarzewska, S.; Ciesielski, W.; Skrzypek, S. J. Environ. Sci. Health B 2014, 49, 550-556.
43. Smarzewska, S.; Guziejewski, D.; Skowron, M.; Skrzypek, S.; Ciesielski, W. Cent. Eur. J. Chem. 2014, 12, 1239- 1245.
44. Smarzewska, S.; Metelka, R.; Guziejewski, D.; Skowron, M.; Skrzypek, S.; Brycht, M.; Ciesielski, W. Anal. Methods 2014, 6, 1884-1889.
45. Phattanawasin, P.; Sotanaphun, U.; Sukwattanasinit, T.; Akkarawaranthorn, J.; Kitchaiya, S. Forensic Sci. Int. 2012, 219, 96-100.
46. Sarbu, C.; Mot, A. C. Talanta 2011, 85, 1112-1117.
47. de Souza, D.; Codognoto, L.; Malagutti, A. R.; Toledo, R. A.; Pedrosa, V. A.; Oliveira, R. T. S.; Mazo, L. H.; Avaca, L. A.; Machado, S. A. S. Quim. Nova 2004, 27, 790-797.
48. Bard, A. J.; Faulkner, L. R. Electrochemical Methods; Wiley: New York, NY, USA, 2001.
49. Gosser, D.K. Cyclic Voltammetry: VCH: New York, NY, USA, 1994.
50. dos Santos, L. B. O.; Abate, G.; Masini, J. C. Talanta 2004, 62, 667-674.
51. Ozkan, S. A. Electroanalytical Methods in Pharmaceutical Analysis and Their Validation; HNB Publishing: New York, NY, USA, 2012.
52. Skowron, M.; Zakrzewski, R.; Ciesielski, W.; Rembisz, Z. ˙ J. Planar Chromat. 2014, 27, 107-112.