Muhammad Kaleem KHOSA, Kieran C. MOLLOY, Sarim DASTGIR, Farkhanda SHAHEEN, Saqib ALI, Muhammad MAZHAR

Synthesis, spectroscopic (FT-IR, $^1 H$, $^13 C$, Mass spectrometry), and biological investigation of five-coordinated germanium-substituted tricyclohewyl antimony dipropionates: Crystal structure of tricyclohexylantimony dipromide

A series of five-coordinated germanium-substituted tricyclohexylantimony dipropionates have been synthesized and characterized by different instrumental techniques, such as elemental analyses, FT-IR, multinuclear NMR $(^1H, ^13C)$ and mass spectrometry. These compounds have also been screened against different microbes and they showed good activity against different bacteria that was comparable to the reference drugs. The crystal structure of the precursor $(C_6H_{11})_3SbBr_2$ is reported here, which showed that the antimony atom in an asymmetric unit exists in trigonal bipyramidal geometry, having space group C2/c with the monoclinic crystal system.

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References 1. K. Bajpai, R. Singhal and R.C. Srivastava, Indian J. Chem., 18A, 73-78 (1979).
2. K. Singhal, R. Rastogi and P. Raj, Indian J. Chem., 26A, 146-150 (1987).
3. G. Ferguson, B. Kaitner, C. Glidewell and S. Smith, J. Organomet. Chem., 419, 283-291 (1991).
4. P.L. Millington and D.B. Sowerby, J. Chem. Soc., Dalton Trans., 1199-1204 (1992).
5. J.S. Li, G.Q. Huang, Y.T. Wei, C.H. Xiong, D.Q. Zhu and Q.L. Xie, Appl. Organomet. Chem., 12, 31-38 (1998).
6. Y.Q. Ma, J.S. Li, Z.N. Xuan and R.C. Liu, J. Organomet. Chem., 620, 235-242 (2001).
7. K. Asai, Miracle Cure: Organic Germanium, Japan Publications, New York 1980.
8. M.A. Choudhary, M. Mazhar, S. Ali, X. Song and G. Engg, Met. Based Drugs, 8, 275-281 (2002).
9. G. K. Sandhu and R. Hundai, Appl. Organomet. Chem., 9, 121-126 (1995).
10. D.D. Perrin and W.L.F. Armarego, Purification of Laboratory Chemicals, 4th Ed., Butterworth, Oxford, 1997.
11. W.J. Lice and R.J. Menzies, J. Chem. Soc., 617-621 (1950).
12. L. Yu, Y.Q. Ma, G.C. Wang and J.S. Li, Heteroatom Chem., 15, 32-36 (2004).
13. S.S. Shaukat, N.A. Khan and F. Ahmad, Pak. J. Bot., 12, 97-106 (1980).
14. Atta-ur-Rehman, M.I. Choudhary and W.J. Thomsen, Bioassay Techniques for Drug Development, Harvard Academy Press Amsterdam, p-14-20, 2001.
15. B.N. Meyer, N.R. Ferrigni, J.E. Putnam, L.B. Jacobson, D.E. Nichols and J.L. McLaughlin, Planta Med., 45, 31-34 (1982).
16. Z. Otwinowski and W. Minor, Methods in Enzymology, Macromolecular Crystallography, Part A; Carter, C.W.; Sweet, R.M. (Eds.); Academic Press, New York, p.307-326, 1997.
17. G.M. Sheldrick, SHELXL-97, University o fG¨ottingen, Germany, 1997.
18. X.Q. Song, Q.L. Xie and X.N. Fang, Heteroatom Chem., 13, 592-601 (2002).
19. J.S. Li, Y.Q. Ma, J.R. Cui and R.O. Wang, Appl. Organomet. Chem., 15, 639-645 (2001).
20. Y.Q. Ma, L. Yu and J.S. Li, Heteroatom Chem., 13, 299-301 (2002).
21. J.S. Li, G.Q. Huang, Y.T. Wei, C.H. Xiong, D.Q. Zhu and Q.L. Xie,. Appl. Organomet. Chem., 12, 31-38 (1998).
22. A. Saeed, Helv. Chim. Acta, 86, 377-383 (2003).
23. H.O.Kalino wski, S. Berger and S. Bro wn, 13C NMR Spektroskopie, Thieme, Verlag, Stuttgart, Germany, p 218, 1984.
24. F. Ahmed, S. Ali, M. Parvez, A. Munir, M. Mazhar, K.M. Khan and T.A. Shah, Heteroatom Chem., 13, 638-649 (2002).