Synthesis of Nitrogen-Containing Heterocycles from the Reaction of Amidrazones with a-Haloesters
The reaction of amidrazones 1 with a-haloesters 2 formed 1,3,5-substituted 4,5-dihydro-1,2,4-triazin-6-ones (4a-z) rather than 1,2,4-triazin-5-one derivatives (5a-z). The microanalysis and spectral data of the synthesized compounds are in full agreement with their molecular structure.
Synthesis of Nitrogen-Containing Heterocycles from the Reaction of Amidrazones with a-Haloesters
The reaction of amidrazones 1 with a-haloesters 2 formed 1,3,5-substituted 4,5-dihydro-1,2,4-triazin-6-ones (4a-z) rather than 1,2,4-triazin-5-one derivatives (5a-z). The microanalysis and spectral data of the synthesized compounds are in full agreement with their molecular structure.
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- R.M. Abdel-Rahman, Pak. J. Sci. Ind. Res. 30, 490 (1987).
- K.C. Joshi, A. Dandia and S. Khanna, Indian J. Chem. 26, 496 (1992).
- K.C. Joshi, R. Jain, A. Dandia and K. Sharma, Indian J. Chem. 28, 698 (1989).
- R.M. Abdel-Rahman, Pharmazine 56, 275 (2001).
- R.M. Abdel-Rahman and M.S. Abdel-Malik, Pak. J. Sci. Ind. Res. 33, 142 (1990).
- R.M. Abdel-Rahman, Pharmaco 46, 379 (1991).
- J. Wiley and H.U.S. Richard, U. S. 358590; Chem. Abstr. 98, 1072143 v (1983).
- B. Boehner, (Ciba-Geigy A.G.) Eur. Pat. (1986); Chem. Abstr. 105, 6522 e (1986).
- M.Z. Badr, M.M. Aly, Z.H. Khalil and A.A. Attalla, Indian J. Chem., Sect. B, 21, 115 (1982).
- G. Pitet, F. Court and Fr. Demande, FR 2500830; Chem. Abstr. 98, 72140 s (1983).
- Z. El-Gendy and R.M. Abdel-Rahman, Indian J. Heterocyclic Chem. 4, 293 (1995).
- Z. El-Gendy, J.M. Morsy, H.A. Allimony, W.R. Abdel-Monem and R. M. Abdel- Rahman, Pharmazine 56, (2001).
- R.M. Abdel-Rahman, M. Seada, M. Fawzy and M. El-Baz, Pharmazine 49, 729 (1994).
- A.S. Shawali, H.M. Hassaneen, A.A. Fahmi and N.M. Abu-Nada, Phosphorous, Sulfur and Silicon 53, 259 (1990).
- A.S. Ferwanah, A.M. Awadallah, E.A. El-Sawi and H.M. Dalloul, Synth. Commun. 33, 1245-1253 (2003).
- H.M. Dalloul and P.H. Boyle, Heterocycl. Commun. 9, 507 (2003).
- M.M. El-Abadelah, A.Q. Hussein and B.A. Thaher, Heterocycles, 32, 1879 (1991).
- A.M. Awadallah, A.S. Ferwanah, E.A. El-Sawi and H.M. Dalloul, Heterocycl. Commun. 8, 369 (2002).