Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations

Simple and accurate spectrophotometric methods are presented for the determination of five 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors (statins), namely atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in pharmaceutical preparations. The methods are based on the reaction of drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as p-acceptors to give highly colored complex species. All variables were studied in order to optimize the reaction conditions. Beer's law was obeyed in the concentration ranges 4--20 m g mL-1, 4--12 m g mL-1, 0.8--2.4 m g mL-1, 4--14 m g mL-1, and 2.5--20 m g mL-1 for atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, respectively. The proposed methods were successfully applied to the pharmaceutical preparations without any interference from excipients.

Anahtar Kelimeler:

HMG-CoA reductase inhibitors, spectrophotometric determination, charge-transfer reaction, TCNQ, pharmaceutical preparations

Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations

Keywords:

HMG-CoA reductase inhibitors, spectrophotometric determination, charge-transfer reaction, TCNQ, pharmaceutical preparations,

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