Meliha Burcu GÜRDERE, Erdoğan KAMO, Ayşe Şahin YAĞLIOĞLU, Yakup BUDAK, Mustafa CEYLAN

89184

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

A series of 1,4-phenylene-bis-chalcones 3a-3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a-5h were obtained by the addition of guanidine hydrochloride to 1,4-phenylene-bis-chalcone 3a-3h in ethanolic KOH under reflux conditions. The structure of the compounds was explained by means of IR, $^{1}$H NMR, $^{13}$C NMR, and elemental analyses. The anticancer activities of 3a-3h and 5a-5h were investigated against rat brain tumor cells and human uterus carcinoma in vitro$.$ Activity tests were performed as dose-dependent assays at eight concentrations. The positive control was 5-fluorouracil (5-FU). Compounds 3c and 3d were examined and they showed high activities as compared to 5-FU against C6 (rat brain tumor) and HeLa (human uterus carcinoma) cells. The anticancer activity of 5h was better than that of 5-FU at high concentrations cell-selectively against C6 cells.
Keywords:

1, 4-Phenylene-bis-chalcone, 1 4-phenylene-bis-pyrimidine, HeLa, C6, anticancer activity, 5-fluorouracil,

PDF
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Tuba Çakir ÇANAK, Serkan AKPINAR, İ. Ersin SERHATLI

Ebru BOZKURT, Halise İnci GÜL, Mehtap TUĞRAK

Efficient multicomponent synthesis of 1,2,3-triazoles catalyzed by Cu(II) supported on PEI@Fe33O44 MNPs in a water/PEG300300 system

Zeinab HASANPOUR, Aziz MALEKI, Morteza HOSSEINI, Lena GORGANNEZHAD, Vajihe NEJADSHAFIEE, Ismaeil HARIRIAN, Abbas SHAFIEE, Ali RAMAZANI, Mehdi KHOOBI

Aslihan KARATEPE, Çağri AKALIN, Mustafa SOYLAK

AISHA SADDIQA, OSMAN ÇAKMAK, MUHAMMAD USMAN

Zakaria Al-Qodah, MOHAMMAD AL-SHANNAG, Abdulaziz Amro, Eman Assirey, Mustafa Bob, Khalid BANİ-MELHEM, Malek ALKASRAWİ

Activity of $\gamma $-Al$_{2}$O$_{3}$-based Mn, Cu, and Co oxide nanocatalysts for selective catalytic reduction of nitric oxide with ammonia

Parvaneh Nakhostin PANAHI, Gerard DELAHAY

MELİHA BURCU GÜRDERE, ERDOĞAN KAMO, YAKUP BUDAK, AYŞE ŞAHİN YAĞLIOĞLU, MUSTAFA CEYLAN

Synthesis and anticancer and cytotoxic effects of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole and 1,4-phenylene-bis-pyrazolylthiazole derivatives

Ayşe ŞAHİN YAĞLIOĞLU, Mustafa CEYLAN, Meliha Burcu GURDERE, Yakup BUDAK, Erdoğan KAMO

Didem Balun KAYAN, Veysel POLAT