MUKUL SHARMA, AFRAIM KOTY, ABDUL JABBAR AL RAJAB

9590

A simple and effective method for determination of the antithyroid drug carbimazole using ruthenium trichloride

An accurate, precise, and simple spectrophotometric method is proposed for the determination of the antithyroid drug carbimazole using ruthenium(III) chloride. This method is based on the formation at room temperature of a stable yellow-colored complex with λ$_{max}$ 370 nm. The method has a Beer's law range of 7.81 to 1.95 $\times $ 10$^{2}$ $\mu $g mL$^{-1}$, molar absorptivity coefficient $\varepsilon =$ 1.519 $\times $ 10$^{3}$ L mol$^{-1}$ cm$^{-1}$, and correlation coefficient of 0.997. The metal:ligand (M:L) ratio of the complex was confirmed by the mole ratio and Job's method of continuous variation, suggesting a 1:2 stoichiometry. The formed carbimazole:Ru(III) complex was confirmed by spectral studies, including Fourier transform infrared, nuclear magnetic resonance, electron spin resonance, magnetic susceptibility, thermal analysis, and powder--X-ray diffraction. Our method could be adopted for routine analysis of carbimazole, due to its ease, affordability, and effectiveness.
Keywords:

Carbimazole, pharmaceutical, detection Ru(III), Fourier transform infrared, spectrophotometric,

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Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
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