The effect of interaction of Rauwolfia vomitoria root bark extract with vitamin E on rats’ liver enzymes
In our previous paper we demonstrated the influence of Rauwolfia vomitoria root bark extract on cardiac enzymes of normal Wistar rats and the effectiveness of this root bark as a source of antihypertensive agent, as determined by the marker enzymes, would be a useful index for the toxicity of this plant in clinical application. In this paper we present the results of the effect of Rauwolfia vomitoria root bark extract and its interaction with vitamin E on the liver function enzymes, such as alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST), gamma glutamyl transferase (g-GT), and the histological architectures of the liver tissues of normal animals. The results showed significant (P
Anahtar Kelimeler:
Key words: Rauwolfia vomitoria, root bark, vitamin E, liver enzymes, histopathology
The effect of interaction of Rauwolfia vomitoria root bark extract with vitamin E on rats’ liver enzymes
In our previous paper we demonstrated the influence of Rauwolfia vomitoria root bark extract on cardiac enzymes of normal Wistar rats and the effectiveness of this root bark as a source of antihypertensive agent, as determined by the marker enzymes, would be a useful index for the toxicity of this plant in clinical application. In this paper we present the results of the effect of Rauwolfia vomitoria root bark extract and its interaction with vitamin E on the liver function enzymes, such as alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST), gamma glutamyl transferase (g-GT), and the histological architectures of the liver tissues of normal animals. The results showed significant (P
Keywords:
Key words: Rauwolfia vomitoria, root bark, vitamin E, liver enzymes, histopathology,
___
- 1. Marcus R, Coulstom AM. Fat soluble vitamin A, K, and E. In: Hardman G, Limbird, LE. eds. Therapeutic (9th ed.). Perganon press, INC, Elmsford, New York; 1996; pp: 1573-1590.
- 2. Traber MG. Does vitamin E decrease heart attack risk? Summary and implications with respect to dietary recommendations. J Nutr 131(2): 395S-397S, 2001.
- 3. Mohsun M. Vitamin E. Lancet 345: 170-175, 1995.
- 4. Traber MG. Utilization of vitamin E. Biofactors 10(2-3): 115- 120, 1999
- 5. Akpanabiatu MI, Umoh IB, Eyong EU et al. Influence of Rauwolfia vomitoria root bark extract on cardiac enzymes of normal Wistar albino rats. Biopharmaceut 14(13): 273-278, 2006a.
- 6. Akpanabiatu MI. Effects of the biochemical interactions of vitamins A and E on the toxicity of root bark extract of Rauwolfia vomitoria (Apocynaceae) in Wistar albino rats, PhD, University of Calabar, Calabar, Nigeria, 2006.
- 7. Gubar SI, Konstantinova EP, Kunakh VA. Medicinal and aromatic plants conference proceeding part (4 of 4)1: 330-337. Maastricht, Netherlands, 1993.
- 8. Udosen EO, Ojong AS. Hepatotoxic activity of Sacoglottis gabonensis. Pharmaceut Biol 36(5): 368-371, 1998.
- 9. Akpanabiatu MI, Umoh, IB, Eyong EU et al. Influence of Nauclea latifolia leaf extracts on some hepatic enzymes of rats fed on coconut oil and non-coconut oil meals. Pharmaceut Biol 43(2): 153-157, 2005.
- 10. Akpanabiatu MI, Umoh, IB, Uboh FE et al. Effect of Nauclea latifolia (Sm. Rubisceae) leaf extracts on some rats serum enzymes of clinical significance. Biopharmaceut 14(13): 297- 304, 2006b.
- 11. Ugochukwu NH, Babady NE, Cobourne M et al. Effect of Gongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats. J Biosciences 28(1): 1-5, 2003.
- 12. Akpanabiatu MI, Igiri AO, Eyong EO et al. Biochemical and histological effects of Eleophorbia drupifera leaf extract in Wistar albino rats. Pharmaceut Biol 41(2): 96- 99, 2003.
- 13. Nada SA, Bashandy SAE, Negm SA. Evaluation of the hypoglycemic activity of traditional herbal preparation in male diabetic rats. Fitoterapy 68: 240-244, 1997.
- 14. Abdel-Baset Halim, Omar El-Ahmady, Samar Hassab Allah et al. Biochemical effect of antioxidants on lipids and liver function in experimentally induced liver damage. Ann Clin Biochem 34: 656-663, 1997.
- 15. Owu DU, Osim EE, Ebong PE. Serum liver enzymes profile of Wistar rats following chronic consumption of fresh or oxidized palm oil diets. Acta Tropica 69: 65-73, 1998
- 16. Cabrera-Abreu JC, Green A. γ-glutamyltransferase: value of its measurement in paediatrics. Ann Clin Biochem 39: 22-25, 2002.
- 17. Moss D, Henderson R. Clinical enzymology. In: Burtis CA, Ashwood ER. eds. Tietz Testbook of Clinical Chemistry. WE Saunders, Philadelphia; 1999: pp. 686-689.
- 18. Vivekananthan DP, Penn MS, Shapp SK et al. Use of antioxidant vitamin E for the prevention of the cardiac disease: Meta analysis of randomized trials. Lancet 36: 2017-2023, 2003.
- ISSN: 1300-0152
- Yayın Aralığı: Yılda 6 Sayı
- Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler
Ayper BOĞA, Seçil BİNOKAY, Yaşar SERTDEMİR
Monday Isaiah AKPANABIATU, Friday Effiong UBOH, Theresa Bassey EKANEM, Imeh Ben UMOH, Eyong Ubana EYONG, Sylvanus O. UKAFIA
Monday İsaiah AKPANABIATU, Friday Effiong UBOH, Theresa Bassey EKANEM, İmeh Ben UMOH
Pal ADWITIYA, Prabhu ASHWINI, Arun Kumar AVINASH, Rajagopal BADRI, Dadhe KAJAL, Ponnamma VOMSI, Shivakumar SRIVIDYA
Cytogenetic effects of fungicide applications on meiosis of tomato (Lycoppersicon esculentum Mill.)
Productive replication of Malacosoma neustria nucleopolyhedrovirus (ManeNPV) in Md203 cell line
İsmail DEMİR, Nurten GÜREL, Remziye NALÇACIOĞLU, İkbal A. İNCE, Zihni DEMİRBAĞ
Pushpa Srinivas MURTHY, Babasaheb Bhaskarrao BORSE, Hafeeza KHANUM, Pullabhatla SRINIVAS
Genetic repairing through storage of gamma irradiated seeds in inbred maize (Zea mays L.)
Girjesh KUMAR, Prashant Kumar RAI
Ayper BOĞA, Yaşar SERTDEMİR, Seçil BİNOKAY
Kala zeera (Bunium persicum Bioss.): a Kashmirian high value crop