For much of cancer the adequate biodisponibility at the tumoral level, without over-exposure of healthy fabrics, remains a major limitation for an effective chemotherapy and not very toxic, the improvement of the specificity of action and the prevention of toxicity represent the main axes of research under full development. The greatest challenge in cancerology is to improve specificity of action of the anti-cancer drugs by detection of the cancer cells and treatment selective of these sick cells. The anti-cancer ones discovered during first decades of chemotherapy interacted mainly with the DNA or its precursors inhibiting the synthesis again material genetics, or causing extended from the natural products most conventional, these substances are themselves a source for the synthesis or the hemisynthesis of other anti-cancer molecules. In this context, the objectives of our work were to give a chemical and therapeutic study of anti-cancer derived from medicinal herbs and to demonstrate the principals methods of obtaining of these anti-cancer derivatives