İlk doz seftriakson enjeksiyonu sonrası anafilaksi
Seftriakson bakteriyel enfeksiyonlar›n tedavisinde kullan›lan üçüncü kuflak bir sefalosporindir. Literatürde seftriyaksonla ilk karfl›laflmadan sonra anafilaksi geliflti¤i bildirilen sadece bir çocuk olgu vard›r. Bu yaz›da damardan seftriakson enfüzyonu sonras›nda anafilaktik flok geliflen iki yafl›nda erkek hasta sunulmufltur. ‹lk doz seftriakson tedavisi sonras› nadir de olsa anafilaksi geliflebilece¤i ak›lda tutulmal›d›r
Anaphylaxis after the first dose of ceftriaxone injection
Ceftriaxone is a third generation cephalosporin used for bacterial infections. In the literature there is only one case of anaphylaxis after first exposure to ceftriaxone in children. Here we report a 2 years old boy who developed anaphylaxis after receiving the first intravenous injection of ceftriaxone. Clinicians should be aware of the risk of anaphylaxis after the first dose of ceftriaxone.
___
- 1. Kelkar PS, Li JT-C. Cephalosporin allergy. N J Eng Med 2001: 345; 804-9. (Full Text)
- 2. Ernst MR, van Dijken PJ, Kabel PJ, Draaisma JM. Anaphylaxis after first exposure to ceftriaxone. Acta Pediatr 2002; 91: 355-6. (Abstract) / (PDF)
- 3. Meyers BR. Comparative toxicities of third-generation cephalosporins. Am J Med 1985; 79: 96-103. (Abstract) / (PDF)
- 4. Lin RY. A perspective on penicilin allergy. Arch Intern Med 1992; 152: 930-7. (Abstract) / (PDF)
- 5. Hoffman DR, Hudson P, Carlyle SJ, Massello III W. Three cases of fatal anaphylaxis in patients with prior histories of allergy to the drug. Ann Allergy 1989; 62: 91-3. (Abstract)
- 6. Citak A, Garratty G, Ucsel R, Karabocuoglu M, Uzel N. Ceftriaxone-induced haemolytic anaemia in a child with no immune deficiency or haematological disease. J Paediatr Child Health 2002; 38: 209-10. (Abstract) / (PDF)
- 7. Baumgartner-Bonnevay C, Choquet-Kastylevsky G, Putet G, Bleyzac N, Vial T, Descotes J. Anaphylactic shock associated with ceftriaxone therapy in a newborn. Arch Pediatr 2002; 9: 1050-2. (Abstract)
- 8. Petz LD. Immunologic cross reactivity between penicillins and cephalosporins: a review. J Infect Dis 1978: 137: 74-9. (Abstract)
- 9. Anne S, Reisman RE. Risk of administering cephalosporin antibiotics to patients with histories of penicilin allergy. Ann Allergy Asthma Immunol 1995; 64: 167-70. (Abstract)
- 10. Harle DG, Baldo BA. Drugs as allergens: an immunoassay for detecting Ig E antibodies to cephalosporins. Int Arch Allergy Appl Immunol 1992; 92: 439-44. (Abstract)
- 11. Saxon A, Beall GN, Rohr AS, Adelman DC. Immediate hypersensitivity reactions to beta lactam antibiotics. Ann Intern Med 1987; 107: 204-15. (Abstract)