Makbule EREN, Nujin ULUĞ, Yusuf AYDEMİR

Gastrointestinal sistem kanaması ve protein kaybettiren enteropati nedeni olarak eozinofilik gastroenterit

Eozinofilik gastroenterit gastrointestinal kanalın herhangi bir bölümünün eozinofilik infiltrasyonu ile belirgin enflamatuar bir hastalıktır.Belirti ve bulguları eozinofilik infiltarasyonun derinliğine ve bölgesinebağlı olarak heterojendir. Bu makalede akut üst gastrointestinal sistemkanaması ve protein kaybettiren enteropati bulguları ile başvuran veeozinofilik gastroenterit tanısı alan iki hasta sunulmuştur. Olgularınher ikisinin de üst endoskopisinde mukozal yalancı kitle görünümlerisaptanmıştır. Her iki hasta da proton pompa inhibitörü ve eliminasyondiyeti tedavisine iyi klinik yanıt vermiştir.

Eosinophilic gastroenteritis as a cause of gastrointestinaltract bleeding and protein-losing enteropathy

Eosinophilic gastroenteritis is an inflammatory disease characterized by pathologic eosinophilic infiltration of any portion of the gastrointestinal tract. Depending on the involved site and layer of eosinophilic infiltration, symptoms and signs are heterogeneous. This manuscript reports two patients who presented with acute upper gastrointestinal tract bleeding and protein-losing enteropathy signs, and were diagnosed as having eosinophilic gastroenteritis. Upper endoscopy revealed an appearance of mucosal pseudomass in both patients. Both patients achieved satisfactory clinical improvement with an elimination diet and proton pump inhibitor treatmen

PDF

___

1. Pineton de Chambrun G, Gonzalez F, Canva JY, et al. Natural history of eosinophilic gastroenteritis. Clin Gastroenterol Hepatol 2011; 9: 950–6.e1.
2. Choi JS, Choi SJ, Lee KJ, et al. Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children. Pediatr Gastroenterol Hepatol Nutr 2015; 18: 253–60.
3. Cianferoni A, Spergel JM. Eosinophilic Esophagitis and Gastroenteritis. Curr Allergy Asthma Rep 2015; 15: 58.
4. Chehade M, Sicherer SH, Magid MS, Rosenberg HK, Morotti RA. Multiple exudative ulcers and pseudopolyps in allergic eosinophilic gastroenteritis that responded to dietary therapy. J Pediatr Gastroenterol Nutr 2007; 45: 354–57.
5. Abou Rached A, El Hajj W. Eosinophilic gastroenteritis: Approach to diagnosis and management. World J Gastrointest Pharmacol Ther 2016; 7: 513–23.
6. Jensen ET, Martin CF, Kappelman MD, Dellon ES. Prevalence of Eosinophilic Gastritis, Gastroenteritis, and Colitis: Estimates From a National Administrative Database. J Pediatr Gastroenterol Nutr 2016; 62: 36–42.
7. Klein NC, Hargrove RL, Sleisenger MH, Jeffries GH. Eosinophilic gastroenteritis. Medicine (Baltimore) 1970; 49: 299–319.
8. Yamada Y, Toki F, Yamamoto H, Nishi A, Kato M. Proton pump inhibitor treatment decreased duodenal and esophageal eosinophilia in a case of eosinophilic gastroenteritis. Allergol Int 2015; 64: S83–5.
9. Lucendo AJ, Serrano-Montalbán B, Arias Á, Redondo O, Tenias JM. Efficacy of Dietary Treatment for Inducing Disease Remission in Eosinophilic Gastroenteritis. J Pediatr Gastroenterol Nutr 2015; 61: 56–64.
10. Sugnanam KK, Collins JT, Smith PK, et al. Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy 2007; 62: 1257–60.