Therapeutic Benefit of Intracavitary-interstitial Brachytherapy in Cervical Cancer Patients with Small and Large High-risk Clinical Target Volume

Therapeutic Benefit of Intracavitary-interstitial Brachytherapy in Cervical Cancer Patients with Small and Large High-risk Clinical Target Volume

OBJECTIVE We aimed to investigate the added value of interstitial brachytherapy (IS-BT) over classical intracavitary BT (IC-BT) in terms of target coverage and organ at risk (OAR) sparing among patients for whom an optimal dose distribution could not be provided without IS-ICBT and also to determine if the magnitude advantage provided by IS-BT is similar in patients smaller (

___

  • 1. Fokdal L, Sturdza A, Mazeron R, Haie-Meder C, Tan LT, Gillham C, et al. Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study. Radiother Oncol 2016;120(3):434–40.
  • 2. Nomden CN, de Leeuw AA, Moerland MA, Roesink JM, Tersteeg RJ, Jurgenliemk-Schulz IM. Clinical use of the Utrecht applicator for combined intracavitary/ interstitial brachytherapy treatment in locally advanced cervical cancer. Int J Radiat Oncol Biol Phys 2012;82(4):1424–30.
  • 3. Jurgenliemk-Schulz IM, Tersteeg RJ, Roesink JM, Bijmolt S, Nomden CN, Moerland MA, et al. MRI-guided treatment-planning optimisation in intracavitary or combined intracavitary/interstitial PDR brachytherapy using tandem ovoid applicators in locally advanced cervical cancer. Radiother Oncol. 2009;93(2):322–30.
  • 4. Kirisits C, Lang S, Dimopoulos J, Berger D, Georg D, Potter R. The Vienna applicator for combined intracav itary and interstitial brachytherapy of cervical cancer: Design, application, treatment planning, and dosimetric results. Int J Radiat Oncol Biol Phys 2006;65(2):624–30.
  • 5. Tambas M, Tavli B, Bilici N, Dizman A, Sertel H, Fayda M. Computed tomography-guided optimization of needle insertion for combined intracavitary/ interstitial brachytherapy with utrecht applicator in locally advanced cervical cancer. Pract Radiat Oncol 2021;11(4):272–81.
  • 6. Haie-Meder C, Potter R, Van Limbergen E, Briot E, De Brabandere M, Dimopoulos J, et al. Recommendations from gynaecological (GYN) GEC-ESTRO working group (I): Concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol 2005;74(3):235–45.
  • 7. Potter R, Haie-Meder C, Van Limbergen E, Barillot I, De Brabandere M, Dimopoulos J, et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D imagebased treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol 2006;78(1):67–77.
  • 8. Hellebust TP, Kirisits C, Berger D, Perez-Calatayud J, De Brabandere M, De Leeuw A, et al. Recommendations from gynaecological (GYN) GEC-ESTRO working group: Considerations and pitfalls in commissioning and applicator reconstruction in 3D image-based treatment planning of cervix cancer brachytherapy. Radiother Oncol 2010;96(2):153–60.
  • 9. Dimopoulos JC, Petrow P, Tanderup K, Petric P, Berger D, Kirisits C, et al. Recommendations from gynaecological (GYN) GEC-ESTRO working group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy. Radiother Oncol 2012;103(1):113–22.
  • 10.Berger T, Seppenwoolde Y, Potter R, Assenholt MS, Lindegaard JC, Nout RA, et al. Importance of technique, target selection, contouring, dose prescription, and dose-planning in external beam radiation therapy for cervical cancer: Evolution of practice from EMBRACE-I to II. Int J Radiat Oncol Biol Phys 2019;104(4):885–94.
  • 11.Fokdal L, Tanderup K, Hokland SB, Rohl L, Pedersen EM, Nielsen SK, et al. Clinical feasibility of combined intracavitary/interstitial brachytherapy in locally advanced cervical cancer employing MRI with a tandem/ring applicator in situ and virtual preplanning of the interstitial component. Radiother Oncol 2013;107(1):63–8.
  • 12.Potter R, Georg P, Dimopoulos JC, Grimm M, Berger D, Nesvacil N, et al. Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer. Radiother Oncol 2011;100(1):116–23.
  • 13.Dimopoulos JC, Kirisits C, Petric P, Georg P, Lang S, Berger D, et al. The Vienna applicator for combined intracavitary and interstitial brachytherapy of cervical cancer: Clinical feasibility and preliminary results. Int J Radiat Oncol Biol Phys 2006;66(1):83–90.
  • 14.Otter S, Coates A, Franklin A, Cunningham M, Stewart A. Improving dose delivery by adding interstitial catheters to fixed geometry applicators in high-doserate brachytherapy for cervical cancer. Brachytherapy 2018;17(3):580–6.
  • 15.Nomden CN, de Leeuw AA, Van Limbergen E, de Brabandere M, Nulens A, Nout RA, et al. Multicentre treatment planning study of MRI-guided brachytherapy for cervical cancer: Comparison between tandem-ovoid applicator users. Radiother Oncol 2013;107(1):82–7.
  • 16.Serban M, Kirisits C, de Leeuw A, Potter R, Jurgenliemk-Schulz I, Nesvacil N, et al. Ring versus ovoids and intracavitary versus intracavitary-interstitial applicators in cervical cancer brachytherapy: Results from the EMBRACE I study. Int J Radiat Oncol Biol Phys 2020;106(5):1052–62.
  • 17.Tanderup K, Fokdal LU, Sturdza A, Haie-Meder C, Mazeron R, van Limbergen E, et al. Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer. Radiother Oncol 2016;120(3):441–6.
  • 18.Mazeron R, Gouy S, Escande A, Dumas I, Del Campo ER, Bentivegna E, et al. Locally advanced cervical cancer: Is it relevant to report image-guided adaptive brachytherapy using point A dose? Brachytherapy 2017;16(4):862–9.
  • 19.Kirchheiner K, Nout RA, Lindegaard JC, HaieMeder C, Mahantshetty U, Segedin B, et al. Doseeffect relationship and risk factors for vaginal stenosis after definitive radio(chemo)therapy with image-guided brachytherapy for locally advanced cervical cancer in the EMBRACE study. Radiother Oncol 2016;118(1):160–6.
  • 20.Manea E, Escande A, Bockel S, Khettab M, Dumas I, Lazarescu I, et al. Risk of late urinary complications following image guided adaptive brachytherapy for locally advanced cervical cancer: Refining bladder dose-volume parameters. Int J Radiat Oncol Biol Phys 2018;101(2):411–20.
  • 21.Spampinato S, Fokdal LU, Potter R, Haie-Meder C, Lindegaard JC, Schmid MP, et al. Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis. Radiother Oncol 2021;158:312–20.
Türk Onkoloji Dergisi-Cover
  • ISSN: 1300-7467
  • Başlangıç: 2015
  • Yayıncı: Ali Cangül
Sayıdaki Diğer Makaleler

Perception of Illness, Coping Style, and Magical Ideation in Patients with Breast Cancer

Ayşe Gökçen GÜNDOĞMUŞ, Yasemin KOÇYİĞİT, Başaran DEMİR

Radiotherapy Equipment and Workforce in Turkey

Kadir YARAY, Tamer Oğuz GÜRSOY, Hatice Bilge BECERİR, Salih GÜRDALLI, Bülent YAPICI, Fadime ALKAYA, Aydın ÇAKIR

Prediction of Survival and Progression-free Survival Using Machine Learning in Stage III Lung Cancer: A Pilot Study

Güntülü AK, Melek YAKAR, Durmuş ETİZ, Muzaffer METİNTAŞ, Şenay YILMAZ, Özer ÇELİK

The Effect of Henna in Nail Changes Due to Paclitaxel Treatment

Gülbeyaz CAN, Emel Emine KAYIKÇI

Investigation of Methylation Status of Homeobox D3 (HOXD3) and Protocadherin 17 (PCDH17) in Patients with Prostate Cancer

Berna DEMİRCAN, Asıf YILDIRIM, Özgür EFİLOĞLU, Hatice İKİIŞIK, Burcu YÜCEL, Alper KAYA, Aslı KARAMAN, Ahsen Merve BAYRAK

Promoter Hypermethylation and Underexpression of Patched Homolog 1 in Pancreatic and Colorectal Cancers: A Cross-Sectional Study

Rauf Ahmad WANI, Madiha NIYAZ, Mosin Saleem KHAN, Syed MUDASSAR, Aaliya SHAH, Omar Javid SHAH, Syed BESINA

The Relationship of Ki-67 Over-expression with Clinicopathological Prognostic Parameters in Invasive Breast Carcinomas

Şennur İLVAN, Tülin ÖZTÜRK, Hale DEMİR, Buğra Taygun GÜLLE

Evaluation of Prognostic and Predictive Values of Hemogram Parameters in Patients with Advanced Stage Ovarian Carcinoma

Yağmur MİNARECİ, Samet TOPUZ, Sezai VATANSEVER, Nail PAKSOY, Erdem BEKTAŞ, Naziye AK, Ferhat FERHATOĞLU, Esra AYDIN, İzzet DOĞAN, Mert KARACA, Hilal OĞUZ SOYDİNÇ, Hamdullah SÖZEN, Pınar MUALLA SAİP

Compatibility of MRI and Pathological Tumor Regression Grading in Patients with Locally Advanced Rectal Cancer After Undergoing Neoadjuvant Chemoradiotherapy

Ebru AKAY, İpek Pınar ARAL, Alaettin ARSLAN, Saliha KARAGÖZ EREN, Gamze TÜRK, Nail ÖZHAN

Prediction of Response to Neoadjuvant Chemoradiotherapy with Machine Learning in Rectal Cancer: A Pilot Study

Özer ÇELİK, Bartu BADAK, Alaattin ÖZEN, Evrim YILMAZ, Melek YAKAR, Durmuş ETİZ, Deniz KÜTRİ