The Use of High-Volume Endorectal Balloon is Effective to Reduce Doses of Rectum and Bladder in ProstateCancer Patients Treated with Linac-Based StereotacticBody Radiotherapy

The Use of High-Volume Endorectal Balloon is Effective to Reduce Doses of Rectum and Bladder in ProstateCancer Patients Treated with Linac-Based StereotacticBody Radiotherapy

In this study, the effect of endorectal balloon (ERB) on risky organ doses was investigated in patients with low-medium risk prostate cancer treated with Stereotactic body radiotherapy (SBRT).METHODSIn the 17 patients, CT simulation and treatment was performed with an empty rectum and no ERB was used (non-ERB group). ERB filled with 100-150 cc air into 15 patients was placed in the rectum and identified with the ERB group. SBRT was performed to be delivered with volumetric modulated arc, with 10 FFF photon beams, using a linear accelerator with a high definition MLC. Dosimetric parameters for the rectum, bladder and penilbulb were compared between the two groups as a retrospective. Independent samples t-tests were performed to examine the differences between the two groups.RESULTSThe mean dose given to the rectum was lower in the ERB group than in the non-ERB group, and a statistically significant dose reduction of 149.4 cGy per fraction was found in the ERB group (p

___

  • 1. Brand DH, Tree AC, Ostler P, van der Voet H, Loblaw A, Chu W, et al. Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial. Lancet Oncol 2019;20(11):1531–43.
  • 2. National Comprehensive Cancer Network.NCCN clinical practice guidelines in oncology: prostate cancer. Available at: https://www.nccn.org/professionals/ physician_gls/pdf/prostate.pdf. Accessed Aug 1, 2018.
  • 3. Hamdy FC, Donovan JL, Lane JA, et al. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer. N Engl J Med 2016;375(15):1415–24.
  • 4. Donovan JL, Hamdy FC, Lane JA, Mason M, Metcalfe C, Walsh E, et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. N Engl J Med 2016;375(15):1425–37.
  • 5. Miralbell R, Roberts SA, Zubizarreta E, Hendry JH. Dose-fractionation sensitivity of prostate cancer deduced from radiotherapy outcomes of 5,969 patients in seven international institutional datasets: α/β = 1.4 (0.9-2.2) Gy. Int J Radiat Oncol Biol Phys 2012;82(1):17–24.
  • 6. De Los Santos J, Popple R, Agazaryan N, Bayouth JE, Bissonnette JP, Bucci MK, et al. Image guided radiation therapy (IGRT) technologies for radiation therapy localization and delivery. Int J Radiat Oncol Biol Phys 2013;87(1):33–45.
  • 7. Madsen BL, Hsi RA, Pham HT, Fowler JF, Esagui L, Corman J. Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: first clinical trial results. Int J Radiat Oncol Biol Phys 2007;67(4):1099–105.
  • 8. King CR, Brooks JD, Gill H, Pawlicki T, Cotrutz C, Presti JC Jr. Stereotactic body radiotherapy for localized prostate cancer: interim results of a prospective phase II clinical trial. Int J Radiat Oncol Biol Phys 2009;73(4):1043–8.
  • 9. Freeman DE, King CR. Stereotactic body radiotherapy for low-risk prostate cancer: five-year outcomes. Radiat Oncol 2011;6:3.
  • 10.McBride SM, Wong DS, Dombrowski JJ, Harkins B, Tapella P, Hanscom HN, et al. Hypofractionated stereotactic body radiotherapy in low-risk prostate adenocarcinoma: preliminary results of a multi-institutional phase 1 feasibility trial. Cancer 2012;118(15):3681–90.
  • 11.King CR, Brooks JD, Gill H, Presti JC Jr. Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer. Int J Radiat Oncol Biol Phys 2012;82(2):877–82.
  • 12.Dearnaley D, Syndikus I, Mossop H, Khoo V, Birtle A, Bloomfield D, et al. Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. Lancet Oncol 2016;(8):1047–60.
  • 13.Lee WR, Dignam JJ, Amin MB, Bruner DW, Low D, Swanson GP, et al. Randomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer. J Clin Oncol 2016;34(20):2325–32.
  • 14.Catton CN, Lukka H, Gu CS, Martin JM, Supiot S, Chung PWM, et al. Randomized Trial of a Hypofractionated Radiation Regimen for the Treatment of Localized Prostate Cancer. J Clin Oncol 2017;35(17):1884–90.
  • 15.Incrocci L, Wortel RC, Alemayehu WG, Aluwini S, Schimmel E, Krol S, et al. Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): final efficacy results from a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol 2016;17(8):1061–9.
  • 16.Musunuru HB, Quon H, Davidson M, Cheung P, Zhang L, D’Alimonte L, et al. Dose-escalation of five-fraction SABR in prostate cancer: Toxicity comparison of two prospective trials. Radiother Oncol 2016;118(1):112–7.
  • 17.Loblaw A, Pickles T, Crook J, Martin AG, Vigneault E, Souhami L, et al. Stereotactic Ablative Radiotherapy Versus Low Dose Rate Brachytherapy or External Beam Radiotherapy: Propensity Score Matched Analyses of Canadian Data. Clin Oncol (R Coll Radiol) 2017;29(3):161–70.
  • 18.Both S, Wang KK, Plastaras JP, Deville C, Bar Ad V, Tochner Z, et al. Real-time study of prostate intrafraction motion during external beam radiotherapy with daily endorectal balloon. Int J Radiat Oncol Biol Phys 2011;81(5):1302–9.
  • 19.Smeenk RJ, Louwe RJ, Langen KM, Shah AP, Kupelian PA, van Lin EN, et al. An endorectal balloon reduces intrafraction prostate motion during radiotherapy. Int J Radiat Oncol Biol Phys 2012;83(2):661–9.
  • 20.Wang KK, Vapiwala N, Deville C, Plastaras JP, Scheuermann R, Lin H, et al. A study to quantify the effectiveness of daily endorectal balloon for prostate intrafraction motion management. Int J Radiat Oncol Biol Phys 2012;83(3):1055–63.
  • 21.Smeenk RJ, van Lin EN, van Kollenburg P, McColl GM, Kunze-Busch M, Kaanders JH. Endorectal balloon reduces anorectal doses in post-prostatectomy intensity-modulated radiotherapy. Radiother Oncol 2011;101(3):465–70.
  • 22.Smeenk RJ, Teh BS, Butler EB, van Lin EN, Kaanders JH. Is there a role for endorectal balloons in prostate radiotherapy? A systematic review. Radiother Oncol 2010;95(3):277–82.
  • 23.Wachter S, Gerstner N, Dorner D, Goldner G, Colotto A, Wambersie A, et al. The influence of a rectal balloon tube as internal immobilization device on variations of volumes and dose-volume histograms during treatment course of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2002;52(1):91–100.
  • 24.Patel RR, Orton N, Tomé WA, Chappell R, Ritter MA. Rectal dose sparing with a balloon catheter and ultrasound localization in conformal radiation therapy for prostate cancer. Radiother Oncol 2003;67(3):285–94.
  • 25.Smeenk RJ, van Lin EN, van Kollenburg P, Kunze-Busch M, Kaanders JH. Anal wall sparing effect of an endorectal balloon in 3D conformal and intensity-modulated prostate radiotherapy. Radiother Oncol 2009;93(1):131–6.
  • 26. van Lin EN, Hoffmann AL, van Kollenburg P, Leer JW, Visser AG. Rectal wall sparing effect of three different endorectal balloons in 3D conformal and IMRT prostate radiotherapy. Int J Radiat Oncol Biol Phys 2005;63(2):565–76.
  • 27.Wortel RC, Heemsbergen WD, Smeenk RJ, Witte MG, Krol SDG, Pos FJ, et al. Local Protocol Variations for Image Guided Radiation Therapy in the Multicenter Dutch Hypofractionation (HYPRO) Trial: Impact of Rectal Balloon and MRI Delineation on Anorectal Dose and Gastrointestinal Toxicity Levels. Int J Radiat Oncol Biol Phys 2017;99(5):1243–52.
  • 28.Vlachaki MT, Teslow TN, Amosson C, Uy NW, Ahmad S. IMRT versus conventional 3DCRT on prostate and normal tissue dosimetry using an endorectal balloon for prostate immobilization. Med Dosim 2005;30(2):69–75.
  • 29.Jones BL, Gan G, Diot Q, Kavanagh B, Timmerman RD, Miften M. Dosimetric and deformation effects of image-guided interventions during stereotactic body radiation therapy of the prostate using an endorectal balloon. Med Phys 2012;39(6):3080–8.
  • 30.Xiang HF, Lu HM, Efstathiou JA, Zietman AL, De Armas R, Harris K, et al. Dosimetric impacts of endorectal balloon in CyberKnife stereotactic body radiation therapy (SBRT) for early-stage prostate cancer. J Appl Clin Med Phys 2017;18(3):37–43.
  • 31.Jaccard M, Lamanna G, Dubouloz A, Rouzaud M, Miralbell R, Zilli T. Dose optimization and endorectal balloon for internal pudendal arteries sparing in prostate SBRT. Phys Med 2019;61:28–32.
Türk Onkoloji Dergisi-Cover
  • ISSN: 1300-7467
  • Başlangıç: 2015
  • Yayıncı: Ali Cangül
Sayıdaki Diğer Makaleler

Development of an Attitude Scale for Cancer Screening

Mehmet UYAR, Elif Nur YILDIRIM ÖZTÜRK, Tahir Kemal ŞAHİN

Synchronous Burkitt’s Lymphoma of Breast and Colonin a Female Patient: A Report of a Case and Review ofLiterature

Mohammad Eslami JOUYBARİ, Anahita NOSRATİ, Marzieh BATHAEİ, Elham Sadat BANİMOSTAFAVİ, Mohammad Mehdi Ghaffari HAMEDANİ, Abdolrahim AHMADİ

The Use of High-Volume Endorectal Balloon is Effective to Reduce Doses of Rectum and Bladder in ProstateCancer Patients Treated with Linac-Based StereotacticBody Radiotherapy

Mete GÜNDOĞ, Hatice BAŞARAN, Okan ORHAN, Kadir YARAY, Tarkan AKSÖZEN, Esin KİRAZ, Celalettin EROĞLU

Cost-Effectiveness Analysis of Leuprorelin Acetate Atrigelin the Treatment of Prostate Cancer

Gökhan ÖZYİĞİT, Fadıl AKYOL

Determination of Body Image, Self-Esteem and DepressionStates among Patients with Gynecological Cancer

Evrim BAYRAKTAR, Nurcan DÜZGÜN

High Capacity of the Metastatic Breast Tumor Cells inSphere Formation: Clue for Chemoresistance in Triple-Negative Breast Cancer

Mohammad Kamalabadi FARAHANİ

Effect of Risk Factors on Local and Systemic Control inStage 1 Endometrial Cancer

Binnur DÖNMEZ YILMAZ, Özge KANDEMİR GÜRSEL

Unusual Localized Non-Hodkin Lymphoma: Left VentricularGiant Mass in a Patient Admitted with Syncope

Hakan GÜNEŞ, Enes ÇELİK, Mehmet KİRİŞÇİ, Bayram ÖZTÜRK, Murat KERKÜTLÜOĞLU

The Role of Pathology in Predicting ImmunotherapyResponse in Urogenital Tumors

Yasemin ÖZLÜK

Effects of Oral Health Care Education on the Severity ofOral Mucositis in Pediatric Oncology Patients

Tuba EREN, Remziye SEMERCİ, Melahat AKGÜN KOSTAK, Esra Nur KOCAASLAN, Filiz YILDIZ