Abuzer DİRİCAN, Bülent ÜNAL, Burak IŞIK, Fatih SÜMER, Cüneyt KAYAALP, İlhan ASLAN

Mide Kanserlerinde Preoperatif Serum CEA, CA19-9 ve AFP Düzeylerinin Klinikopatolojik Faktörlerle Korelasyonu

Amaç: Gastrik adenokarsinomlu hastalarda preoperatif serum karsinoemriyonik antijen (CEA), CA19-9 ve alfa-fetoprotein (AFP) düzeyi ile klinikopatolojik faktörlerin korelasyonunu araştırmak. Metot: Gastrik adenokarsinom sebebiyle Ankara Yıldırım Beyazıt Eğitim Hastanesi 2. Cerrahi Kliniğinde ameliyat edilen 74 hastanın kayıtları retrospektif olarak incelendi. Hastaların preoperatif serum CEA, CA19-9, AFP düzeyleri ile bazı klinikopatolojik faktörler (tümör evresi, karaciğer metastazı, peritoneal metastaz, asit varlığı, tümörün rezeke edilebilirliği) arasındaki korelasyon araştırıldı. Bulgular: Hastaların preoperatif serum CEA, CA19-9, AFP pozitiflik oranları sırası ile %31.4, 30.3 ve 16.4 olarak bulundu. Hastaların 31'inde (%41,8) bir veya birden fazla tümör markırı yüksek iken, 8'inde (%13.1) üç markır da yüksek bulundu. Bu 8 hastanın 6'sı evre 4, 2'si evre 3 teki hastalardı. Sonuç: Gastrik adenokarsinomlu hastalarda preoperatif serum CEA, CA19-9, AFP seviyelerinin ileri evreli, karaciğer metastazı yapmış, rezektabıl olmayan tümörlerde anlamlı oranda yüksek olduğu görüldü. Anahtar kelimeler: Gastrik Adenokarsinom, CEA, CA19-9, AFP, Klinikopatolojik Faktörler

Anahtar Kelimeler:

Gastrik Adenokarsinom, CEA, CA19-9, AFP, Klinikopatolojik Faktörler

Corelation between Preoperative Serum CEA, CA19-9, and AFP Levels and Clinicopathologic Factors

Objectives: To investigate the correlation between preoperative serums CEA, CA19-9, and alphafetoprotein (AFP) levels and clinic pathological factors. Methods: The correlation between the records of pre-operative serum CEA, CA19-9, and alpha-fetoprotein levels and some clinic-pathological factors (tumor stage, liver metastasis, peritoneal metastasis, presence of ascites, unresectable tumors) of 74 patients with gastric adenocarcinoma operated in Ankara Yildirim Beyazit Education and Training Hospital 2nd Surgery Clinic was investigated. Results: Preoperative elevated serum CEA, CA19-9, and alpha-fetoprotein levels were found 31.4%, 30.3, and 16.4, respectively. While 31 (41.8%) out of 74 patients had one or more positive tumor markers, all three markers were found to be high in 8 patients (13.1%). Six of these patients were in stage 4, and the other two patients were in stage 3. Conclusion: Preoperative serum CEA, CA19-9, and alpha-fetoprotein levels were found high in patients with advanced stage, liver metastases, and unresectable gastric adenocarcinoma. Keywords: Gastric Adenocarcinoma, CEA, CA19-9, AFP, Clinicopathologic Factors

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Kodera Y, Yamamura Y, Torii A, Yasui K, Morimoto T, Kato T, Kito T. The prognostic value of preoperatif Serum levels of CEA and CA19-9 inpatient with gastric cancer: The American Journal of gastroenterology 1996; 91:149-53.
Nakane Y, Okamura S, Akehira K, Koiki K. Corelation of preoperative CEA levels and prognosis of gastric cancer patients. Cancer 1994;73: 2703 - 2708.
Koga K, Kano T, Sounda K, Kioki K. The clinical usefulness of preoperative CEA determination in gastric cancer. Japanase Journal of Surgery 1987;17: 342-347.
Shimizu N, Wakutsuki T, Murakami A, Maeta M, Koga S. CEA in gastric patients. Oncology 1987;44: 240-244.
Dittrich C, Jakaesz R, Havelec L, et al. CEA plasma level determination in the managemeof gastric cancer patients. Cancer Determinattion and Prevention 1985;8: 181-187.
Yoshihiko M, Keizo S, Masanobu A. Serum CEA level increseases correlate with tumor progression in patients with differentiated gastric carcinoma following noncurative resection . Cancer Research 50(11) (1990) pp.3952-55.
Kornek G, Depisch D, Temsch EM, Scheithauer W. Comperative analaysis of cancer associated antigen CA195, CA 19-9 and CEA in diagnosis , fallow- up and monitoring to response to chemotherapy in patient s with gastrointestinal cancer . J. Cancer Res Clin Oncol 1991;117:493-496.
Baillari P, Sammaritino P, Cardi M, Cerasi A. Gastrointestinal cancer fallow up : The effectiveness of secuantial CEA ; TPA and CA19-9 evaluation in the early diagnosis of recurances. Aust N Z J Surg 1991;61:675-680.
Takahashi Y, Takeuchı T, Sakamoto J, et al.The usefulness of CEA and/ or CA19-9 in monitoringfor reccurance in gastric cancer patients: a prospective clinical study. Gastric Cancer 2003; 6: 142-145.
Nakajima K, Ochiai T, Suziki T, Shimada H, Hayashi H, Yasumatu A. Impct of preoperative serum CEA, CA19-9,AFP levels in gastric cancer patients . Tumor Biol.1998; 19: 464-469.
Lee R , Rha SY, Ahn JB, Shim KY, Choi JH, Lim HY, Yoo NC, Noh SH, Kim JH, Kim SB, Chung HC. Alpha –Fetoprotein producing gastric cancer. Oncol Rep. 1998;5:1179-84.
Altınbaş E, Polat H, Borazan A, Yeksan M, Ecirli Ş. Mide kanserli olgularda tümör markırlarından AFP, CEA, CA 125 ve CA 19-9’un klinik kullanımlarının incelenmesi. Selçuk Üniv. Tıp Fak. Dergisi 2001;17(1):37-42
Kayaalp C, Arda K, Orug T, Ozcay N. Value of computed tomography in addition to ultrasound for preoperative staging of gastric cancer. European Journal of Sugical Oncology. 2002; 26: 1-4.
De Graaf GW, Avantude AA, Parsons SL, Duffy JP, et al. The role of staging laparoscopy in oesophagogastric cancers. Eur. J. Surg. Oncol. 2007; 33: 988- 92.