Herpes simplex virus tip 1 (HSV-1) antikorları, 85 lösemi ve lenfomalı hasta ve 40 sağlıklı kişide ELİSA yöntemi ile araştırılmıştır. Hasta grubunda HSV-1 IgM ve IgG pozitifliği sırasıyla % 9.41 ve % 92.95, kontrol grubunda da % 0.0 ve % 90 bulunmuştur. İstatistiksel olarak kontrol grubuna göre lösemi ve lenfomalı hastalarda HSV-1 IgM pozitifliği anlamlı olarak yüksektir. HSV-1 IgG antikorları yönünden ise hasta ve kontrol grubu arasında anlamlı fark bulunamadı. HSV-1 IgM ve IgG bakımından lösemi ve lenfomalı hastalar artasında da fark bulunamadı. Ayrıca antineoplastik tedavi alan ve almayan hastalar arasında da fark yoktu. [Turgut Özal Tıp Merkezi Dergisi 1996;3(3):173-176] Anahtar kelimeler: Herpes simpleks virus antikorları, lösemi, lenf oma

Herpes simplex virus type 1 (HSV-1) antibodies were investigated in 85 patients with leukemia and lymphoma and 40 healthy controls by ELISA. In patients HSV-1 IgM and IgG antibodies were found 9.41 % and 92.95 % respectively. In controls the same antibodies were found as 0.0 % and 90 %. Stastically, HSV-1 IgM seropositivity in patients with leukemia and lymphoma was higher than the control group. But there was not a significant difference between patients and control group for HSV-1 IgG. There was not a difference between the patients with leukemia and the patients with lymphoma for HSV-1 IgM and IgG. No significant difference was present between the patients treated with antineoplastic chemotherapy and the patients not treated. [Journal of Turgut Ozal Medical Center 1996;3(3):173-176] Key words: Herpes simplex virus antibodies, leukemia, lymphoma