Bu çalışmada gonartroz bulgularına sahip, ortalama 58 yaşında 40 hastaya bir NSAI ilaç olan tenoxicamın 20 mg/tek doz intra-artikuler uygulanmasının lokal tolerans, güvenilirlik ve etkinliğinin sonuçları değerlendirildi. İntra-artikuler tenoxicam enjeksiyonundan onbeş gün sonra hastaların 16 sında ağrıda büyük oranda iyileşme, 12 sinde iyileşme gözlendi. Hastaların 6 sı enjeksiyondan yarar görmedi kalan 6 sının ağrılarında artma gözlendi. Eklem hareket genişliği hastaların %60 ında arttı. Dört hastada enjeksiyon sonrası hafif lokal reaksiyon gelişti. Ancak hastaların iki ay sonraki muayenelerinde şikayetlerinin arttığı ve ilk muayene bulgularına doğru gerilediği gözlendi. İlk enjeksiyondan 6 ay sonra hastalara ya tekrar NSAI uygulamasına devam edildi veya artroskopik lavaj ve debridman uygulandı. Bu sonuçlarla tek doz İntra-artikuler tenoxicam enjeksiyonun lokal tolerans ve güvenilirlik yönünden uygulanabilir olduğunu ancak uzun süreli etkinlik yönünden yetersiz olduğu ve bu yönde çalışmalara devam edilmesi gerektiğini düşünmekteyiz. [Turgut Özal Tıp Merkezi Dergisi 1997;4(1):67-71J Anahtar kelimeler: Artroskopi, tenoxicam, gonartroz, tedavi

In this study, the local tolerance, reliability and effectiveness of 20 mg/day single dose tenoxicam was evaluated in a group of 40 patients with a mean age of 58 years. 16 of the group recovered and 12 of them had partial pain relief two weeks after application. 6 of the patients showed total failure and another 6 of them had increase in symptoms. The range of movements increased in %60 of the patients. Mild allergic reactions developed after injection in 4 patients. After 2 months, patients showed an increase in complaints and regressed to the symptoms of the first examination. 6 months after the first injection, it was either repeated once more or arthroscpic lavage and debridement were performed. These results reveal that single dose intra-articular injection is a reliable and locally tolerable method in short term but needs further study for evaluation of long term results. [Journal of Turgut Ozal Medical Center 1997;4(1):67-71] KeyWords : Arthroscopy, tenoxicam, gonarthrosis, treatmentIn this study, the local tolerance, reliability and effectiveness of 20 mg/day single dose tenoxicam was evaluated in a group of 40 patients with a mean age of 58 years. 16 of the group recovered and 12 of them had partial pain relief two weeks after application. 6 of the patients showed total failure and another 6 of them had increase in symptoms. The range of movements increased in %60 of the patients. Mild allergic reactions developed after injection in 4 patients. After 2 months, patients showed an increase in complaints and regressed to the symptoms of the first examination. 6 months after the first injection, it was either repeated once more or arthroscpic lavage and debridement were performed. These results reveal that single dose intra-articular injection is a reliable and locally tolerable method in short term but needs further study for evaluation of long term results. [Journal of Turgut Ozal Medical Center 1997;4(1):67-71] KeyWords : Arthroscopy, tenoxicam, gonarthrosis, treatment