Burak BİLGİN, Mutlu HİZAL, Şebnem YÜCEL, Mehmet ŞENDUR, Nalan AKYÜREK, Muhammed Bülent AKINCI, Ülkü YILMAZ, Bülent YALÇIN

The association of clinicopathologic features and peripheral blood parameters with high PD-L1 expression in non-small cell lung cancer

Introduction: Programmed death ligand 1 (PD-L1) is a marker that widelyused for prediction of response to immunotherapy. Dynamic alteration ofPD-L1 expression are the major problems for reflection of the actual status ofthe PD-L1. So, we aimed to investigate the factors that may be associated withPD-L1 expression in lung cancer.Materials and Methods: The patients diagnosed with non-small cell lung cancer were enrolled, retrospectively. The patients were stratified according toPD-L1 expression level as ≥ 50% and < 50%.Results: Totally, 217 patients were enrolled. The clinicopathologic featureswere similar between two groups, except the amount of cigarette consumption. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemicimmune-inflammmotry index were found significantly lower in PD-L1 ≥ 50%(p< 0.001, p= 0.006 and p= 0.003, respectively) and also negatively correlated with PD-L1 level (rho= -0.255, p< 0.001; rho= -0.17, p= 0.013; rho= -0.185, p= 0.006, respectively)Conclusion: According to the results of our study, peripheral blood parameters can be used to the prediction of the high PD-L1expression and can be used for reflection of current PD-L1 expression.

Küçük hücreli dışı akciğer kanserinde yüksek PD-L1 düzeyi ile ilişkili klinikopatolojik faktörlerin ve periferik kan parametrelerinin belirlenmesi

Giriş: “Programmed death ligand 1 (PD-L1)” immünoterapilere yanıtı predikte etmek için yaygın olarak kullanılan bir belirteçtir. Bununla birlikte PD-L1 düzeyinin dinamik değişimi gerçek zamanlı PD-L1 düzeyinin yansıtılması için büyük bir problemdir. Bu sebeple bu çalışmada akciğer kanseri tanısı olan hastalarda PD-L1 düzeyi ile ilişkili olabilecek faktörlerin saptanması amaçlanmıştır. Materyal ve Metod: Küçük hücreli dışı akciğer kanseri tanısı olan hastalar retrospektif olarak çalışmaya dahil edildi. Hastalar PD-L1 ekspresyon düzeyine göre < %50 ve ≥ %50 olmak üzere ikiye ayrıldı. Bulgular: Toplam 217 hasta çalışmaya dahil edildi. Her iki grubun sigara tüketimi dışında klinikopatolojik özellikleri benzerdi. PD-L1 düzeyi ≥ %50 olan grupta nötrofil lenfosit oranı, platelet lenfosit oranı ve sistemik immün inflamatuvar indeks anlamlı olarak daha düşük saptandı (sırasıyla; p< 0.001, p= 0.006 ve p= 0.003). Aynı zamanda bu parametreler PD-L1 ekspresyon düzeyi ile negatif korele olarak saptandı (sırasıyla, rho= -0.255, p< 0.001; rho= -0.17, p= 0.013; rho= -0.185, p= 0.006). Sonuç: Bizim çalışma sonuçlarımıza göre periferal kan parametreleri PD-L1 düzeyini predikte etmek için kullanılabilir ve böylece güncel PD-L1 ekspresyon düzeyi yansıtılabilir

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