A rarely seen diffuse parenchymal lung disease: Diffuse pulmonary meningotheliomatosis
Pulmoner meningotelyal nodüller (PMN) sıklıkla rezeke edilenakciğer parankim örneklerinin ve otopsilerin patolojik incelenmesisırasında rastlantısal olarak saptan ır. Bu nodüller genellikle asemp-tomatik ve ço ğu zaman tektir. Difüz pulmoner tutulum sıklığı dahaazdır. PMN benign lezyonlar olup, neoplastik ve neolastik olmayanakciğer hastalıkları ve nadiren ekstrapulmoner hastalıklarla ilişkilibulunmu ştur. Multipl bilateral pulmoner nodülleri olan ve video eşliğinde torakoskopik cerrahi (VATS) ile "difüz pulmoner meningotelyomatozis" tan ısı alan bir kadın hasta sunulmu ştur. Difüz pulmoner meningotelyomatozis radyolojik olarak difüz bilateral akciğernodülleri olan hastalarda ayırıc ı tan ı içinde yer almalıdır.
Nadir görülen bir difüz parankimal akciğer hastalığı: Difüz pulmoner meningotelyomatozis
Pulmonary meningothelial-like nodules (MLNs) are usually detected incidentally during pathologic evaluation of resected pulmonaryparenchymal specimens and autopsies. These nodules are generally asymptomatic and most often single. Diffuse pulmonary involve-ment by MLNs is less frequently described. MLNs are benign lesions and have been associated with neoplastic and non-neoplasticpulmonary conditions and occasionally with extrapulmonary diseases. We report a case of a female patient presenting with multipleand bilateral pulmonary nodules diagnosed with "diffuse pulmonary meningotheliomatosis" by video-assisted thoracoscopic surgery(VATS). Diffuse pulmonary meningotheliomatosis should be included in the differential diagnosis of diffuse bilateral lung nodules inthe radiologic studies.
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- 1. Suster S, Moran CA. Diffuse pulmonary meningothelioma- tosis. Am J Surg Pathol 2007;31:624-31.
- 2. Mukhopadhyay S, El-Zammar OA, Katzenstein AA. Pulmonary meningothelial-like nodules. New insights into a comman but poorly understood entity. Am J Surg Pathol 2009;33:487-95.
- 3. Mizutani E, Tsuta K, Maeshima AM, Asamura H, Matsuno Y. Minute pulmonary meningothelial-like nodules: clinico- pathologic analysis of 121 patients. Human Pathol 2009;40:678-82.
- 4. Ionescu DN, Sasatomi E, Aldeeb D, Omalu BI, Finkelstein SD, Swalsky PA, et al. Pulmonary meningothelial-like nod- ules. A genotypic comparison with meningiomas. Am J Surg Pathol 2004;28:207-14.
- 5. Kraushaar G, Ajlan AM, English JC, Müller NL. Minute pul- monary meningothelial-like nodules: a case of incidentally detected diffuse cystic micronodules on thin-section com- puted tomography. J Comput Assist Tomogr 2010;34:780- 82.
- 6. Korn D, Bensch K, Liebow A, Castleman B. Multiple minute pulmonary tumors resembling chemodectomas. Am J Pathol 1960;37:641-72.
- 7. Niho S, Yokose T, Nishiwaki Y, Mukai K. Immunohistochemical and clonal analysis of minute pul- monary meningothelial-like nodules. Hum Pathol 1999;30:425-29.
- 8. Pelosi G, Maffini F, Decarli N, Viale G. Progesterone recep- tor immunoreactivity in minute meningotheloid nodules of the lung. Virchows Arch 2002;440:543-46.
- 9. Beigelman-Aubry C, Hill C, Grenier PA. Management of an incidentally discovered pulmonary nodule. Eur Radiol 2007;17:449-66.
- 10. Kuroki M, Nakata H, Masuda T, Hashiguchi N, Tamura S, Nabeshima K, et al. Minute pulmonary meningothelial-like nodules: High resolution computed tomography and pathologic correlations. J Thorac Imaging 2002;17:227-29.
- 11. Sellami D, Gotway MB, Hanks DK, Webb WR. Minute pulmonary meningothelial-like nodules: thin-section CT appearance. J Comput Assist Tomogr 2001;25:311-13.
- 12. Kfoury H, Arafah MA, Arafah MM, Alnassar S, Hajjar W. Mimicry of minute pulmonary meningothelial-like nodules to metastatic deposits in a patient with infiltrating lobular carcinoma: a case report and review of the literature. Korean J Pathol 2012;46:87-91.
- 13. Kamiya K, Yoshizu A, Kashizaki F, Hida N, Hayashi H. Minute pulmonary meningothelial-like nodules coexisting with pulmonary cryptococcosis mimicking lung cancer. Gen Thorac Cardiovasc Surg 2013;61:659-62.
- 14. Mora RB, Nieto JMS, Hu C, Mateos EA, Bascunana AG, Rodriguez MR. Diffuse pulmonary meningotheliomatosis diagnosed by transbronchial lung biopsy. Respiration 2013;86:145-48.
- 15. Lee SK, Kim GJ, Kim YJ, Leem AY, Hwang ED, Kim SK, et al. Minute pulmonary meningothelial-like nodules simulat- ing hematogenous lung metastasis: a case report. Tuberc Respir Dis 2013;75:67-70.