Cutaneous metastases in colorectal cancer

Amaç: Kolorektal kanserin cilt metastazlarıyla klinik uygulamada nadiren karşılaşılır. Bu çalışmada, kolorektal kanserli ve cilt metastazı olan hastaların hastalığın ortaya çıkış bulguları, seyri ve prognozu açışından değerlendirilmesi amaçlanmıştır. Hastalar ve Yöntemler: Kolorektal kanser tanısıyla tedavi edilen ve takiplerinde cilt metastazı gelişen hastalar (7 kadın, 1 erkek; ort. yaş 49; dağılım 28-72) değerlendirildi. Hastaların demografik özellikleri, primer tümör ve cilt metastazlarının yeri, primer tümörün histopatolojik özellikleri ve evresi, eşlik eden diğer metastazların yeri ve tedavi yöntemleri incelendi. Bulgular: Hastaların tümünde evre III kolorektal kanser mevcuttu ve adjuvan kemoterapi ile tedavi edildi. Cilt metastazları cerrahiden ortalama 25 ay sonra ortaya çıktı ve karın ön duvarı ile presakral bölgede yerleşmişti. Cilt metastazlarından sonra takipte yedi hasta ölürken bir hasta 63 aydır sağdır. Cilt metastazlarından sonra ortalama sağkalım süresi 17 aydır. Birinde sadece cilt metastazı olan dört hasta cerrahiden sonra dört yıldan daha fazla yaşamıştır. Sonuç: Kolorektal kanserli hastalarda, şüpheli cilt lezyonları mümkün olduğu kadar erken eksize edilerek sadece cilt metastazı olan hastaların saptanma oranı artırılmalıdır.

Anahtar Kelimeler:

Neoplazm metastazı, Neoplazm evrelendirilmesi, Seyir, Deri neoplazmları, Kolorektal neoplazmlar

Kolorektal kanserde cilt metastazları

Objectives: Cutaneous metastases of colorectal cancer are rarely detected in clinical practice. This study aimed to evaluate the patients with cutaneous metastases of colorectal cancer in order to define their clinical presentation, clinical course, and prognosis. Patients and Methods: Patients (7 females, 1 male; mean age 49 years; range 28 to 72 years) treated for colorectal cancer and who developed cutaneous metastases during follow-up were evaluated. Patients' demographic characteristics, location of the primary tumor and cutaneous metastases, histopathologic properties and stage of the primary tumor, location of accompanying metastases, and treatment methods were recorded. Results: All patients had stage III colorectal cancer and were treated with adjuvant chemotherapy. Cutaneous metastases appeared in a mean duration of 25 months after surgery and were located in the anterior abdominal wall and presacral region. Following cutaneous metastases, seven patients died whereas one patient is alive after 63 months. Mean survival time after cutaneous metastases was 17 months. Four patients survived more than four years from the time of surgery, one of which had only cutaneous metastases. Conclusion: In colorectal cancer patients, suspicious looking skin lesions should be excised as early as possible to increase the detection rate of patients with isolated cutaneous metastases.

Keywords:

Neoplasm Metastasis, Neoplasm Staging, Prognosis, Skin Neoplasms, Colorectal Neoplasms,

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