Emre TEKGÜNDÜZ, Akyol Alev İRİKÇİ, Ahmet ÖZTÜRK

Amifostine treatment of a patient with refractory acute myeloid leukemia

regiİster konvansiyonel kurtarma kemoterapileri isterse araştırma temelli stratejiler kullanılsın, vericisi olmayan çoğu akut myeloid lösemi (AML) hastasının prognozu kötüdür ve bu hastaların çoğu hastalıkları nedeniyle kaybedilir. Dirençli AML hastalarında kalıcı tam yanıt sağlayan standart bir kemoterapi rejimi yoktur. Amifostinin tek başına ve konvansiyonel kemoterapiler ile birlikte kullanımının myelodisplastik sendrom ve kötü prognozlu AML hastalarında yararlı etkileri gösterilmiştir. Burada amifostin içeren sitotoksik olmayan ilaç kombinasyonu ile başarıyla tedavi edilen AML hastalarındaki ikinci deneyimimizi bildiriyoruz. Amifostinin yararlı etkileri birçok kemoterapi ilacının doz artımına olanak sağlayan hücre koruyuculuğu ile sınırlı değildir ve en azından bazı dirençli AML hastalarında kök hücre nakli için bir köprü olarak kullanılabilir.

Anahtar Kelimeler:

Erkek, Amifostin, Erişkin, Lösemi, miyeloid, akut

Dirençli akut myeloid lösemi hastasının amifostin ile tedavisi

The prognosis for the majority of acute myeloid leukemia (AML) patients without a donor is dismal whether conventional salvage chemotherapy regimens or investigational strategies are used, and most of these patients will eventually die of their disease. There is no standard chemotherapy regimen that provides durable complete remission in patients with refractory AML. Beneficial effects of amifostine, either alone or in combination with conventional chemotherapy, was demonstrated in patients with myelodysplastic syndrome and poor prognosis AML. Here we report our second experience with AML patients who were successfully treated with an amifostine containing noncytotoxic drug combination. The beneficial effects of amifostine are not limited to cytoprotectivity which enables doseescalation for many chemotherapeutic agents, at least in some refractory AML it can also be used as a bridge to hematopoietic stem cell transplantation.

Keywords:

Male, Amifostine, Adult, Leukemia, Myeloid, Acute,

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