Pesticides are chemical substances that prevent from harmful organisms and reduce their harms. Pesticides areclassified by their durability time, chemical structure and organisms which it affected. Fungicide is a general term thatgiven to all chemicals which are used to take under control the fungus that infect on plants. Luna Experience SC-400 is a new generation fungicide that combinated with Fluopyram and Tebuconazole. Tebuconazole is a triazole fungicide. Tebuconazole was tested in vitro for its potential genotoxic and cytotoxic effects on cultured bovine peripheral lymphocytes. Fluopyram is a benzamide fungicide. Genotoxic effects of fluopyram was examined and reported in rats. In this study, We used three different doses (5 µg/kg, 10 µg/kg, 20 µg/kg) of Luna Experience-EC 400 during 30 day at 48 h intervals by gavage in rats. We investigated the genotoxicty and cytotoxicty of Luna Experience-EC 400 using comet assay and micronucleus test in rat bone marrow. We found that Luna Experience-EC 400 has genotoxic and cytotoxic potential in rat bone marrow.  There is significant difference between control group and all the doses of Luna Experience-EC 400 (p<0.05) for comet assay levels and micronucleus frequency. In this study, we also investigated the PCE/total erythrocyte rate. All the doses of Luna Experience-EC 400 lead to decreasing the amount of PCEs. It is found that this decrease is statistically significant (p<0.05).