Warfarin is used in cardiovascular disease as an oral anticoagulant agent. Spontaneous hemorrhage is one of the major adverse effects of warfarin. In rare cases, warfarin can cause spontaneous retroperitoneal hemorrhage which may be fatal. In this study, presented a case that death due to massive retroperitoneal hemorrhage related to suicidal warfarin intake. Our case was a 17-year-old female. According to medical and judicial records, she was found unconsciously at her home and died immediately after reached the hospital. External examination revealed marked pale appearance on the skin and mucosal surfaces. There was no any traumatic finding at external examination. The autopsy revealed that a wide hematoma extending from retroperitoneal area to pelvis. Toxicological analysis showed the warfarin in the blood and bile specimens. All forensic investigation file and postmortem examinations evaluated and the case was thought suicide as the origin. Cause of death was non-specific cases, an autopsy is done the necessity and importance of postmodern review once again.