Occupational diseases and exposure are at issue recently in our country. Early diagnosis and corrective actions of occupational diseases provides oppurtunity for preventing from chronic diseases. Clinical laboratories are of great importance especially in diagnosis and monitoring of the treatment. Occupational diseases become more specific due to usage of different sample types in analysis, application of uncommon techniques that is not frequently used in routine laboratories, issues about the preanalytical variables and conditions. Having a deep biochemical knowledge about analysis and parameters will contribute to clinicians.