Rivaroxaban is a direct factor Xa inhibitor and has been safely used since 2008. It is used for the detection ofatrial fibrillation and venous thromboembolism. Pancreatitis is one of the rare but dangerous side effects ofrivaroxaban. The case of a 53-year-old female patient that developed in the third month of drug usage wasevaluated, and it was confirmed after a full analysis was conducted that excluded all other factors, such asbiliary calculus, alcohol usage, hypertriglyceridemia, biochemical parameters, ultrasonography and computedtomography that the patient’s condition was caused by the use of Rivaroxaban. The aim of this case presentationis to indicate that awareness should be increased regarding the risks of using the drug Rivaroxaban, as it couldlead to drug-induced pancreatitis, even though this is rare.