0.05). İstatistiksel açıdan, hasta grubunda Apolipoprotein A-I ortalaması anlamlı düzeyde düşük, trigliserid ve VLDL-kolesterol düzeyi yüksek idi (P<0,01). HDL-kolesterolün 35 mg/dl'nin altında olması (OR=6.86, x2=8.038, P=0.009) ve Apolipoprotein A-I' in 120 mg/dl'nin altında olması (OR=5.50, x2=5.002, P=0.025) önemli risk faktörleri olarak belirlendi. Lipoprotein (a) ile trigliserid düzeyi arasında negatif yönde (rs=-0.401, P<0.01); Apolipoprotein A-I ile HDL-kolesterol arasında (rs=0.766, P<0.001), Apolipoprotein B ile LDL-kolesterol (rs=0.873, P<0.001) ve VLDL-kolesterol (rs=0.457, P<0.001) arasında pozitif yönde anlamlı korelasyonlar belirlendi. Sonuçlar: İskemik serebrovasküler hastalıkların önlenmesi amaç olarak kabul edildiğinde, yapılması gereken aterosklerozla ilişkili olduğu bilinen risk faktörlerinin düzenlenmesi, bunların iyileştirilmesi ile inme insidansı ve prevalansında azalma sağlanmasıdır. Serum Lipoprotein (a), Apolipoprotein A-I and Apolipoprotein B Levels in Ischemic Cerebrovascular Diseases We aimed to investigate the lipid and lipoprotein parameters and atherosclerotic risk factors of the ischemic cerebrovascular diseases in our society. A subject which is still controversial and which still have some arguments for and against its ethiological role in the ischemic cerebrovascular diseases, is lipid and lipoprotein metabolism defects which are thought to take part in the ethiopathology of atherosclerotic diseases. Different results have been obtained of communities living in different geographical places in the investigations of ischemic cerebrovascular diseases. Our study was on 48 patients who had diagnoses of ischemic cerebrovascular disease in the Neurology Department of Haydarpaşa Numune Education and Research Hospital between March 2 and May 25 2000 and 21 healthy controls. Serum total cholesterol, trigliserid, HDL and VLDL-cholesterol Apolipoprotein A-I, Apolipoprotein B, Lipoprotein (a) levels were measured and routine biochemical and haematological measures were performed. Atherosclerotic risk factors such as diabe-tes, hypertension, smoking and obesity were evaluated in the patient group. "SPSS for Windows 10.0" version was used for the statistical evaluation. The difference between the two mean values were evaluated with Student t-test or Mann Whitney-U test when it was necessary. Odds ratio and Mantel Haenszel x2 test were applied for the risk evaluation. Correlations between the variables were evaluated with Spearman Correlation Coefficient. The Lipoprotein (a), Apolipoprotein B, total cholesterol and LDL-cholesterol mean values were almost same for the patient and control groups (P>0.05). While Apolipoprotein A-I level of the patient group was low in a statistically significant manner, trigliserid and VLDL-cholesterol mean values were high (P<0.01). If HDL-cholesterol level was below 35 mg/dl (OR=6.86, x2=8.038, P=0.009) and Apolipoprotein A-I level was below 120 mg/dl (OR=5.50, x2=5.002, P=0.025), they constitute the major risk factors of ischemic cerebrovascular diseases. While there was a negative correlation between Lp (a) and trigliserid levels (rs=-0.401, P<0.01), there was a positive correlation between Apo A-I and HDL-cholesterol (rs=0.766, P<0.001), Apo B and LDL (rs=0.873, P<0.001) and Apo-B and VLDL (rs=0.457, P<0.001) levels. The correlation between Apo A-I and HDL-cholesterol is especially important as they both are risk factors. When our aim is to prevent the occurrences of cerebrovascular diseases, risk factors (Apo A-I and HDL-cholesterol) which have known ethiological roles in atherosclerotic disease, should be observed and by overcoming them the incidence and prevalence of stroke can be decreased.">
[PDF] İskemik serebrovasküler hastalıklarda serum lipoprotein (a), apolipoprotein A-I ve apolipoprotein B düzeyi | [PDF] Serum lipoprotein (a), apolipoprotein A-I and apolipoprotein B levels in ischemic cerebrovascular diseases
0.05). İstatistiksel açıdan, hasta grubunda Apolipoprotein A-I ortalaması anlamlı düzeyde düşük, trigliserid ve VLDL-kolesterol düzeyi yüksek idi (P<0,01). HDL-kolesterolün 35 mg/dl'nin altında olması (OR=6.86, x2=8.038, P=0.009) ve Apolipoprotein A-I' in 120 mg/dl'nin altında olması (OR=5.50, x2=5.002, P=0.025) önemli risk faktörleri olarak belirlendi. Lipoprotein (a) ile trigliserid düzeyi arasında negatif yönde (rs=-0.401, P<0.01); Apolipoprotein A-I ile HDL-kolesterol arasında (rs=0.766, P<0.001), Apolipoprotein B ile LDL-kolesterol (rs=0.873, P<0.001) ve VLDL-kolesterol (rs=0.457, P<0.001) arasında pozitif yönde anlamlı korelasyonlar belirlendi. Sonuçlar: İskemik serebrovasküler hastalıkların önlenmesi amaç olarak kabul edildiğinde, yapılması gereken aterosklerozla ilişkili olduğu bilinen risk faktörlerinin düzenlenmesi, bunların iyileştirilmesi ile inme insidansı ve prevalansında azalma sağlanmasıdır.">
0.05). İstatistiksel açıdan, hasta grubunda Apolipoprotein A-I ortalaması anlamlı düzeyde düşük, trigliserid ve VLDL-kolesterol düzeyi yüksek idi (P<0,01). HDL-kolesterolün 35 mg/dl'nin altında olması (OR=6.86, x2=8.038, P=0.009) ve Apolipoprotein A-I' in 120 mg/dl'nin altında olması (OR=5.50, x2=5.002, P=0.025) önemli risk faktörleri olarak belirlendi. Lipoprotein (a) ile trigliserid düzeyi arasında negatif yönde (rs=-0.401, P<0.01); Apolipoprotein A-I ile HDL-kolesterol arasında (rs=0.766, P<0.001), Apolipoprotein B ile LDL-kolesterol (rs=0.873, P<0.001) ve VLDL-kolesterol (rs=0.457, P<0.001) arasında pozitif yönde anlamlı korelasyonlar belirlendi. Sonuçlar: İskemik serebrovasküler hastalıkların önlenmesi amaç olarak kabul edildiğinde, yapılması gereken aterosklerozla ilişkili olduğu bilinen risk faktörlerinin düzenlenmesi, bunların iyileştirilmesi ile inme insidansı ve prevalansında azalma sağlanmasıdır. Serum Lipoprotein (a), Apolipoprotein A-I and Apolipoprotein B Levels in Ischemic Cerebrovascular Diseases We aimed to investigate the lipid and lipoprotein parameters and atherosclerotic risk factors of the ischemic cerebrovascular diseases in our society. A subject which is still controversial and which still have some arguments for and against its ethiological role in the ischemic cerebrovascular diseases, is lipid and lipoprotein metabolism defects which are thought to take part in the ethiopathology of atherosclerotic diseases. Different results have been obtained of communities living in different geographical places in the investigations of ischemic cerebrovascular diseases. Our study was on 48 patients who had diagnoses of ischemic cerebrovascular disease in the Neurology Department of Haydarpaşa Numune Education and Research Hospital between March 2 and May 25 2000 and 21 healthy controls. Serum total cholesterol, trigliserid, HDL and VLDL-cholesterol Apolipoprotein A-I, Apolipoprotein B, Lipoprotein (a) levels were measured and routine biochemical and haematological measures were performed. Atherosclerotic risk factors such as diabe-tes, hypertension, smoking and obesity were evaluated in the patient group. "SPSS for Windows 10.0" version was used for the statistical evaluation. The difference between the two mean values were evaluated with Student t-test or Mann Whitney-U test when it was necessary. Odds ratio and Mantel Haenszel x2 test were applied for the risk evaluation. Correlations between the variables were evaluated with Spearman Correlation Coefficient. The Lipoprotein (a), Apolipoprotein B, total cholesterol and LDL-cholesterol mean values were almost same for the patient and control groups (P>0.05). While Apolipoprotein A-I level of the patient group was low in a statistically significant manner, trigliserid and VLDL-cholesterol mean values were high (P<0.01). If HDL-cholesterol level was below 35 mg/dl (OR=6.86, x2=8.038, P=0.009) and Apolipoprotein A-I level was below 120 mg/dl (OR=5.50, x2=5.002, P=0.025), they constitute the major risk factors of ischemic cerebrovascular diseases. While there was a negative correlation between Lp (a) and trigliserid levels (rs=-0.401, P<0.01), there was a positive correlation between Apo A-I and HDL-cholesterol (rs=0.766, P<0.001), Apo B and LDL (rs=0.873, P<0.001) and Apo-B and VLDL (rs=0.457, P<0.001) levels. The correlation between Apo A-I and HDL-cholesterol is especially important as they both are risk factors. When our aim is to prevent the occurrences of cerebrovascular diseases, risk factors (Apo A-I and HDL-cholesterol) which have known ethiological roles in atherosclerotic disease, should be observed and by overcoming them the incidence and prevalence of stroke can be decreased.">
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