Bülent KILIÇOĞLU, Serin Sibel KILIÇOĞLU, Veli Çağatay EREN

Gastrointestinal sistemde yara iyileşmesi

Gastrointetsinal sistemde anastomoz kaçakları cerrahide sık rastlanılan problemlerden biridir. Biz bu derlememizde yara iyileşmesindeki lokal ve sistemik faktörlerin yanı sıra cerrahi tekniğin anastomozlardaki etkilerini tartıştık.

Anahtar Kelimeler:

Anastomoz, cerrahi, Yara iyileşmesi, Gastrointestinal kanal

Wound healing in gastrointestinal tract

Anastomotic leak of gastrointestinal tract is one of the most common problems. İn This review we discussed the effect of surgical tecnique in anastomose besides the local and Systemic factors in wound healing.

Keywords:

Anastomosis, Surgical, Wound Healing, Gastrointestinal Tract,

PDF

___

1. Koruda MJ,Rolandelli RH.Experimental studies on the healing of colonic anastomoses. J Sug Res 1990 May;48(5):504.
2. Debas HT, Thomson FB: Acritical review of colectomy with anastomoses 1972. 541-556
3. Irvin TT, Hunt TK, The effect of trauma on colonic healing. Br. J. Surgery 1974; 61:430
4. Rolandelli RH, Buckmine MA, Bernstein KA. Intravenous butyrate and healing of colonic anastomoses in rat. Dis Colon Rectum 1197 Jan;40(1):67
5. Karaasnoğlu T, Alçiçek S, Altunkaya E, et al. Effect on fibrin glue on irradiated colonic anastomoses. Dis Colon Rektum 1997 Oct; 40(10):1240
6. Wutzler P, Sauerbrei A, Klöcking R, Burkhardt J, Schacke M, Trust R, Fleischer W, Reimer K. Virucidal and chlamydicidal activities of eye drops with povidone-iodine liposome complex. Ophtalmic Res 200;32:118-125
7. Reimer K, Vogt P.M, Broegmann B, Hauser J, Rossbach O, Kramer A, Rudolph P, Bosse B, Schreier H, Fleicher W. An annovative topical drug formulation for wound healing and infection treatment: in vitro and in vivo investigations of a povidone- iodine liposome hydrogel. Dermatology 2000;201:235-241
8. K. Reimer, W. Fleischer, B. Brögmann, H. Schreier, P. Burrkhard, A. Lanzendörfer, H. Gümbel, H. Hoekstra, W. Behrens-Baumann: Povidone-Iodine Liposomes- An overview. Dermatology 1997;195(suppl 2):93-96
9. Thornton FJ, Barbul A. Healing in the gastrointestinal tract. Surg. Clin North Am 1997;77:549-573
10. Marks R, Dykes P, Motley R. Clinical Sings and Procedures in dermatology 1. st ed. London 1993;35
11. Arnold HL, Odom RB, James WD. Andews Disease of the skin, clinical Dermatology,8th ed. WB Sounders Company, Philadelphia. 1990
12. Witt MB,Barbul A.General principles of wound healing. Surg Clin North Am June 77:509-528,1997
13. Necmi Akut ve kronik yara bakımı Ankara 2003 Sayfa 17-33
14. Kalaycı Göksel Genel cerrahi 1. Cilt Ankara 2002 Sayfa 53-60
15. Cronin K, Jackson DS, Dunphy JE. Chaging bursting strength and collagen content of the healling colon. Surg Gynecol obstet 126 (4): 747 53, 1968
16. Graham MF, Drucker DE, Diegelmann RE, Elson CO. Collegen synthesis by human intestinal smooth muscle cells in culture. Gastroenterology 92(2):400-405,1987.
17. Martens MF , Huyben CM. Hendriks T. Collegen synthesis in fibroblast from human colon: Regulatory aspects differences with skin fibroblasts. Gut 33(12):16664-70,1992.
18. Graham MF, Blomguist P, Zederfeldt B. The alimantary canal. (In) Wound healing: Biochemical and clinical Aspects (Eds) Cohen IK, Diegelmann RF, Lindblad WJ. WB Sunders Company 1992, Philadelphia:433-449.
19. Brasken P. Healing of experimental colon anastomases. Eur J Surg 1991;Suppl 566:8-51.
20. Mast BA: Healing in other tissues. Surg Clin North Am 77:529-47,1997
21. Oxlund H, Chritensen H, Seyer-Hansen M,Andreasses TT. Collagen deposition and mechanical strength of colon anastomoses and skin incisional wounds of rats. J Surg Res 66:25-30, 1996.
22. Högström H, Haglund U. Postoperative decrease in suture holding capacity in laparatomy wounds and anastomoses. Acta Chir Scand 1985;151:533-535
23. Hesp Flem, Hendriks T, Lubbers A-JC, de-Boer HHM: Wound healing in the intestinal wall: A comparison between experimental ileal and colonic anastomoses. Dis colon Rectum 1984:27;99-104
24. Martens MF WC, Hendriks TH: Postoperative changes in cologens synthesis in intestinal anastomoses of the rat: differences between small and large bowel. Gut,1991:32;1482-1487.
25. Gabriel A. Ghtulescu, Nancy Morin, Prasad Jetty, Paul Belliveau Revisiting the biofragmentable anastomotic ring: Is it safe in colonic surgeyr? An Surg 2003 April ;46(2): 98-98
26. Ora R., Levy Y., Sayfan Y. Suturless intestinal anastomosis with a biyofragmentable anastomotic ring. Harefual 1992 Nov 1;123(9): 31 3-5, 372
27. Dİ Castrol A., Biancari F., Brocato R., Adam EA., Truosolo B., Massi G. Ýntestinal anastomosis with the biyofragmentable anastomosis ring. Am J surg 1998 Nov; 176(5): 472-4
28. Choi HJ., Kim HH., Jung GJ., Kim SS. Intestinal anastomosis by use of the biyofragmentable anastomotic ring: isit safe and efficacious in emergeny operations as well? Dis colon Rectum 1998 oct; 41(10): 1281-6
29. Valle M., Biancari F., caviglia A., D'Andrea V., Baselice PF. The biyofragmentable anastomotic ring in electiv colon resections. Int Surg 1998 Jan-Mar;83(1):58-9
30. Wany SM., Lai IR., Liang JT.,Chang KJ. Colorectal surgery using a biyofragmentable anastomotik ring. Taiwan yi zhi. J 1996 oct;95(10):798-801
31. Konishi F., Saito Y.,Ugajim H., Okada M. Sutureless anastomosis useing a biyofragmentable anastomotik ring Surg Today 1995;25(9):783-9
32. Coloshield -1 Ravo B Dis Colon Rectum Jul 1988; 31(7):579-2
33. Coloshield-2 Egozi L., Sorrento JJ., Golub R. Dir Kolon Rectum Feb 1993;36(2):191-3
34. Kanellos I., Mantzoros I., Goulimaris I., Zacharakis E., Zavitsanakis A., Betsis D, Effects of the use of fibrin glue around the colonic anastomos of the rat. Tech Coloproctol 2003 jul;7(2):82-4,
35. Kiyama T, Onada M, Tokunaga A, Efron DT, Barbul A Effect of matrix matalloproteinase inhibition on colonic anactomotic healing in rats. J Gastrointest Sugr 2001 May-Jun;5(3):303-11
36. Shaper KR, Savage FJ, Herbry RM, Boulos PB regulation matrix metalloproteinases in a madel of colonic would healing in a rabbit. Dis colon Rectum 2001 dec;44(12):1857-66
37. Sarıbeyoğlu T,Baca B,Hamzaoğlu I,Pekmezci Z,Karahasanoğlu T Hamzaoğlu H.Dose becaplermin(Platelet-derived growth factor-BB) revers detrimental effects of ischemia on colonic anastomosis? Dis Colon rectum 2003 Apr;46(4):516-20
38. Güler M, Koloğlu M, Kama NA, Renda N, Gozanan U, Yüksek YN, Dağlar G .Effect of topically applied charged particles on healing of colonic anastomoses. Arch Surg 2002 Jul;137(7):813-7
39. Kashiwagi H. The lower limit of tissue blood flow for safe colonic anastomoses: An experimental study ysing lase doppler velocimetry. Surg Today 1993;23:430- 438.
40. Goligher LC, Et.Al: Acontrolled comparison of one and two layer technigues of for high and low colorectal anastomoses. Bj j surg 1977; 64: 609-614.
41. Yeşilkaya Y, Soyhan N, Bengisu N. The effects of different Suture technigues on collagen metabolism in experimental distal colonic anastomoses. Br.J.surg.1985;72:987.
42. Schilling JA. Wound Healing. Surg Cli North Am. 1976;56:859-874.
43. Hawley PR: Causes and prevention of anastomotic breakdown. Dis. Colon Rectum 1973 jul. 16:4,272-277
44. Uluocak K,Kolon anastomoz yetmezliklerinin sebepleri ve önlenmesi. Dirim 1992;67.sayı 1-2:34-42
45. Hawley PR, Fault WP, Hunt TK, Durphy JE: Collagenase activity in the gastrointestinal tract. Br.J.Surg. 1970; 57:896-901
46. Irvin TT: Collagen metaboloism in infected colonic anastomoses. Br. J. Surg. 1975;62:659
47. Schrock TR, Deveney CW, Dunfy JE: Factors contributing to leakage of colonic anastomosis. Ann Surg 1973;177:513-51
48. Smith JH, Connlly JC, Carne PW ve ark. The effect of drainage materials on colonic healing. Br J Surg 1982;69:153-155
49. Aguilar-Nascimento JE, Mathie RT, Man WK, Williamson RC: Enhanced intraanastomic healing by operative lavage with nutrient solutions in experimental left- sided colonic obstruction. Br J Surg 1995;82:461- 464
50. Tsunado A, Shibusawa M, Kamiyama G, Takata M,Choh H, Kusano M: Iodine absorption after intraoperative bowel irrigation with povidone-iodine. Dis Colon Rectum 2000;43:1127-1132
51. Speyer JL, Sugabaker PH: 5- FU chemotherapy and pelvic radiation in the treatment of large bowel cancer. Surgery 1986;58:826-83
52. Bland K, Palin W, Von Frauenhofer A, Morris R, AdcockR, Tobin G. Experimental and clinical observations of the effects of cytotoxic chemotherapeutic drugs on wound healing. Ann Surg 1994 ;199:782-790
53. Demetriades H,Botsios D,Kazantzidou D ve ark. Effect of early postoperative enteral feeding on the healing colonic anastomoses in rats. Eye J Res 1999;31:57-63
54. Tadros T, Wobbes T, Hendriks T Blood transfusion impairs the healing of experimental intestinal anastomoses. Ann Surg 1992;215:276-281
55. Foster ME, Laycock JRD, Silver IA and Leaper DJ: Hypovolaemia and healing in colonic anastomoses. Br J Surg 1985, Vol 72. October, 831-834
56. Koloğlu M, Sayer I, Koloğlu ve ark: Effect of persistently elavated intraabdominal pressure on healing of colonic anastomoses. Am J Surg 1999;178:293-297.
57. Foster ME,Laycock JRD, Silve IA ve ark. Hypovlemia and healing in clonic anastomoses. Br J Surg 1985;72:831-834
58. Hartmann M, Jönsson K, Zederfeldt B. Importance of dehydration in anastomotic and subcutaneous wound healing: An experimental study in rats. Eur J Surg 1992;158:79-82
59. Heughan C, Grislis G, Hunt TK. The effect of anemia on wound healing. Am J Surg 1974;179:163-167.
60. Hunt TK, Zederfeldt B, Goldstick TK. Oxygen and healing. Am J Surg 1969;118:521-526.
61. Eubanks TR,Greenberg JJ, Hendriks T,, Wobbes T ve ark. The effects of different corticosteroids on the healing colon anastomoses and cecum in rat model. Am J Surg 1997;63:266-269
62. Ehrlich P, Hunt TK. The effect of cortisone and anabolic steroids on the tensile strength of healing wound. Ann Surg. 1969;170:203-306.
63. Kim SC, Buchmiller LT, Fonkalsrud WE, Philips D. The effect of anabolic steroids on ameliorating the advers effect of chronic corticosteroids on intestinal anastomotic healing in rabbits. Gyn. And Obs. Surg. 1993;176:73-79
64. Hendriks T, Mastboom WBJ. Healing of ex. Intestinal anastomoses parameters for repair. Dis colon Rectum 1990;33(10):891-901
65. Hamzaoğlu İ, Karahasanoğlu T, Aydın S,Şahin DA, Çarkman S,Sarıyar M, Alemdaroğlu K. The effects of hyperbaric oxygen on normal and ischemic colon anastomoses. Am J Surg 1998;176:458-461.
66. De Roy van Zuidewijin DB, Henriks T, Wobbes T ve ark. Healing of Intraperitoneal colonic anastomoses: Effect of antineoplastic agent. Eur J Surg Oncol 1987;13:27-33
67.De Roy van Zuidewijin DB, Henriks T, Wobbes T ve ark. Intraperitoneal-cytostatics impair healing of experimental intestinal anastomoses. Br J Cancer 1991;63:937-941
68. Tümer AR, Kama NA, Tümer L ve ark Effects of 5- fluorouracil and zinc on healing of colonic anastomoses in rabbits. Eur J Surg 1999;165:369-377
69. Mast BA,Cohen IK,Diegelman RF,Linbland WJ. Wound healing: Philedelphia, WB Company, 1992 1. Ed: 344-355
70. Kuşlu SN. Diabetik sıçanlarda kolon anastomozuna epidermal growth faktörün etkisi. Uzmanlık tezi 1997.
71. Mustoe TA, Cutler NR, Allman RM ve ark. Aphase II studyu to evaluate recombinant platelet-derived growth factor-BB in treatment of stage 3 and 4 pressure ulcers. Arch Surg 1994;129:213-219.
72. Christensen H, Ckemmitz J, Christensen BC, Oxlund H Collogen structural organisation of healing colonic anastomoses and the effect of growth hormon treatment. Dis Colon Rectum 1995;38:11.
73. Gainant A. Prevention of anastomotic dehiscence in colorektal surgery . J Chir (Paris) 2000 feb;137(1):45-50