Poliglikolik Asit’ in (PGA) Biyomedikal uygulamaları
Biyobozunur polimerler, biyobozunurluk ve biyouyumluluk özelliklerinden dolayı biyomedikal uygulamalarda büyük potansiyele sahip olup yaygın şekilde kullanılmaktadır. Biyobozunur polimerler yapılarında hidrolitik olarak kararsız fonksiyonel gruplar (örneğin, esterler, anhidritler vd.) içerirler. Bu hidrolitik olarak kararsız gruplar kolayca hidroliz olabilmekte, veya mikroorganizmalar tarafından yenilebilmektedir. Bu sayede polimerlerin bozunması gerçekleşir. Biyobozunur polimerler birçok biyomedikal alanda (örneğin; ilaç salınımı, dişçilik, ortopedi, ve doku mühendisliği) etkili bir biçimde kullanılabilmektedir. Poliglikolik asit (PGA) oldukça iyi bozunma davranışından dolayı tıp alanında yaygın şekilde kullanılan bir materyaldir. Ancak, PGA polimerlerinin biyomedikal uygulamaları alanında sınırlı sayıda araştırma mevcuttur. PGA birçok çözücü içerisinde çözünememekte ve hızlı bir şekilde bozunmaya uğramaktadır. Bu derleme hidrolitik olarak bozunabilen PGA’ nın biyomedikal alanda kullanımındaki yenilikleri açıklayacaktır.
Biomedical applications of polyglycolic acid (PGA)
Biodegradable polymers have a great potential and widely used in biomedical applications due to theirbiodegradability and biocompatibility. Biodegradable polymers contain hydrolytically unstable functionalgroups (such as esters, anhydrides and etc.) in their backbone. These hydrolytically unstable functionalgroups can be hydrolyzed, or eaten by microorganisms, and degradability happens. Biodegradable polymerscan be effectively used for several biomedical applications such as drug delivery, dental, orthopedic andtissue engineering. Polyglycolic acid (PGA) is a desired material for physicians due to its excellentdegradation behaviour. However, limited research based on PGA polymers has been studied in biomedicalapplications due to insolubility of PGA in most of the solvents and rapid degradation of PGA. This reviewwill focus on the improvements made in the development of hydrolytically degradable PGA in biomedicalfields.
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- M. Kolybaba, L. G. Tabil, S. Panigrahi, W.
J. Crerar, T. Powell, and B. Wang. (2003).
Biodegradable Polymers: Past, Present, and
Future. Presented at the American Society of
Agricultural Engineers (ASAE), Paper
Number: RRV03-0007. [online]. Available:
http://www.biodeg.net/fichiers/Biodegradab
le%20Polymers%20Past,%20Present,%20a
nd%20Future%20(Eng).pdf.
- C. K. Williams. (13 July 2007). Synthesis of
functionalized biodegradable polyesters.
Chem. Soc. Rev. [online]. 36, pp.1573–1580.
Available:
http://pubs.rsc.org/en/Content/ArticleLandi
ng/2007/CS/b614342n#!divAbstract.
- N. Lucas, C. Bienaime, C. Belloy, M.
Queneudec, F. Silvestre, and J. E. NavaSaucedo.
(September 2008). Polymer
biodegradation: mechanisms and estimation
techniques. Chemosphere. [online]. 73(4),
pp. 429–442. Available:
http://www.sciencedirect.com/science/articl
e/pii/S0045653508008333.
- E. Piskin. (1995). Biodegradable polymers
as biomaterials. J. Biomater. Sci. Polym. Ed.
[online]. 6(9), pp. 775-795. Available:
http://www.tandfonline.com/doi/abs/10.116
3/156856295X00175?journalCode=tbsp20.
- V. Singh and M. Tiwari. (25 September
2010). Structure-Processing-Property
Relationship of Poly(Glycolic Acid) for
Drug Delivery Systems 1:Synthesis and
Catalysis. Int. J. of Polym. Sci. [online].
Article ID 652719:23 pages. Available:
https://www.hindawi.com/journals/ijps/201
0/652719/.
- B. D. Ulery, L. S. Nair, and C. T. Laurencin.
(15 June 2011). Biomedical applications of
biodegradable polymers. Journal of Polymer
Science Part B: Polymer Physics. [online].
49(12), pp. 832–864. Available:
http://onlinelibrary.wiley.com/doi/10.1002/
polb.22259/abstract.
- A. W. Lloyd. (February 2002). Interfacial
bioengineering to enhance surface
biocompatibility. Med. Device Technol.
[online]. 13(1), pp. 18–21. Available:
https://www.ncbi.nlm.nih.gov/pubmed/119
21776.
- I. Vroman and L. Tighzert. (1 April 2009).
Biodegradable Polymers. Materials.
[online]. 2(2), pp. 307-344.
doi:10.3390/ma2020307. Available:
http://www.mdpi.com/1996-1944/2/2/307.
- J. Middleton and A. Tipton. (1 March 1998).
Synthetic biodegradable polymers as
medical devices. MDDI medical device and
diagnostic industry news products and
suppliers. [online]. Available:
http://www.mddionline.com/article/syntheti
c-biodegradable-polymers-medical-devices.
- E. Göktürk, A. G. Pemba, and S. A. Miller.
(28 April 2015). Polyglycolic acid from the
direct polymerization of renewable C1
feedstocks. Polym. Chem. [online]. 6, pp.
3918–3925. Available:
http://pubs.rsc.org/en/Content/ArticleLandi
ng/2015/PY/c5py00230c#!divAbstract.
- P. Dobrzynski, J. Kasperczyk, and B.
Maciej. (18 June 1999). Application of
Calcium Acetylacetonate to the
Polymerization of Glycolide and
Copolymerization of Glycolide with ε–
Caprolactone and L-Lactide.
Macromolecules. [online]. 32(14), pp.
4735–4737. Available:
http://pubs.acs.org/doi/abs/10.1021/ma9819
69z.
- E. J. Frazza and E. E. Schmitt. (March
1971). A new absorbable suture. J. Biomed.
Mater. Res. [online]. 5(2), pp. 43-58.
Available:
http://onlinelibrary.wiley.com/doi/10.1002/j
bm.820050207/abstract.
- A. R. Katz and R. J. Turner. (October 1970).
Evaluation of tensile and absorption
properties of polyglycolic acid sutures. Surg.
Gynecol. Obstet. [online]. 131(4), pp. 701–
716. Available:
https://www.ncbi.nlm.nih.gov/pubmed/545
8531.
- Kuredux Polyglycolic Acid (PGA) Resin, A
New Polymer Option, [online]. Available:
http://www.kureha.com/productgroups/pga.htm.
- E. E. Schmitt and R. A. Polistina. (10
January 1967). Surgical sutures. US patent
3,297,033. [online]. Available:
https://docs.google.com/viewer?url=patenti
mages.storage.googleapis.com/pdfs/US329
7033.pdf.
- S. W. Shalaby and R. A. Johnson, “Synthetic
absorbable polyesters”, Biomedical
polymers: Designed to degrade systems, S.
W. Shalaby, Ed. New York: Hanser, 1994,
pp.1-34.
- J. Fu, J. Fiegel and J. Hanes. (25 August
2004). Synthesis and Characterization of
PEG-Based Ether−Anhydride Terpolymers:
Novel Polymers for Controlled Drug
Delivery. Macromolecules. [online]. 37(19),
pp. 7174–7180. Available:
http://pubs.acs.org/doi/abs/10.1021/ma0498
53s.
- O. Bostman, E. Hirvensalo, S. Vainionpaa,
A. Makela, K. Vihtonen, P. Tormala, and P.
Rokkanen. (January 1989). Ankle fractures
treated using biodegradable internal fixation.
Clin. Orthop. Related Res. [online]. 238, pp.
195-203. Available:
http://journals.lww.com/corr/Abstract/1989/
01000/Ankle_Fractures_Treated_Using_Bi
odegradable.28.aspx.
- O. Bostman, E. Hirvensalo, S. Vainionpaa,
K. Vihtonen, P. Tormala, and P. Rokkanen.
(1990). Degradable polyglycolide rods for
the internal fixation of displaced bimalleolar
fractures. Int. Orthop. (SICOT). [online].
14(1), pp: 1-8. Available: https://www.ncbi.nlm.nih.gov/pubmed/216
0439.
- E. Hirvensalo. (October 1989). Fracture
fixation with biodegradable rods. Forty-one
cases of severe ankle fractures. Acta Orthop.
Stand. [online]. 60(5), pp. 601-606.
Available:
https://www.ncbi.nlm.nih.gov/pubmed/255
7718.
- O. Bostman, E. Hirvensalo, J. Makinen, and
P. Rokkanen. (July 1990). Foreign-body
reactions to fracture fixation implants of
biodegradable synthetic polymers. J Bone
Joint Surg. [online]. 72(4), pp. 592-596.
Available:
http://www.bjj.boneandjoint.org.uk/content/
jbjsbr/72-B/4/592.full.pdf.
- K. A. Athanasiou, G. G. Niederauer, and C.
M. Agrawal. (January 1996). Sterilization,
toxicity, biocompatibility and clinical
applications of polylactic acid/ polyglycolic
acid copolymers. Biomoterials. [online].
17(2), pp. 93-102. Available:
http://www.sciencedirect.com/science/articl
e/pii/0142961296857541.
- B. K. Behera. (25 November 2013).
Pharmaceutical Applications of Lactides and
Glycolides: A Review. Journal of Medical
and Pharmaceutical Innovation. [online].
1(1), pp. 1-5. Available:
http://www.jmedpharm.com/index.php?jour
nal=JMPI&page=article&op=view&path%
5B%5D=4.
- D. Gilding and A. M. Reed. (December
1979). Biodegradable polymers for use in
surgery-polyglycolic/poly(lactic acid)
homo- and copolymers: 1. Polymer.
[online]. 20(12), pp. 1459-1464. Available:
http://www.sciencedirect.com/science/articl
e/pii/0032386179900090.
- I. P. Matthews, C. Gibson, and A. H.
Samuel. (13 September 1989). Enhancement
of the kinetics of the aeration of ethylene
oxide sterilized polymers using microwave
radiation. J. Biomed. Mater. Res. [online].
23(2), pp. 143-156. Available:
http://onlinelibrary.wiley.com/doi/10.1002/j
bm.820230202/pdf.
- Y. Chen, L. Tan, L. Chen, Y. Yang, and X.
Wang. (June 2008). Study on Biodegradable
Aromatic/Aliphatic Copolyesters. Brazilian Journal of Chemical Engineering. [online].
25(02), pp. 321-335. Available:
http://www.scielo.br/pdf/bjce/v25n2/a11v2
5n2.pdf.
- S. D. Andrew, G. C. Phil, and K. G. Marra.
(August 2001). The influence of polymer
blend composition on the degradation of
polymer/hydroxyapatite biomaterials. J.
Mater. Sci: Mater. Med. [online]. 12(8), pp.
673–677. Available:
http://link.springer.com/article/10.1023/A:1
011204106373.
- W. Heidemann, S. Jeschkeit, K. Ruffieux, J.
H. Fischer, M. Wagner, G. Kruger, and et al.
(September 2001). Degradation of
poly(D,L)lactide implants with or without
addition of calciumphosphates in vivo.
Biomaterials. [online]. 22(17), pp. 2371–
2381. Available:
https://www.ncbi.nlm.nih.gov/pubmed/115
11034.
- J. C. Middleton and A. J. Tipton. (1
December 2000). Synthetic biodegradable
polymers as orthopedic devices.
Biomaterials. [online]. 21(23), pp. 2335-
2346. Available:
http://www.sciencedirect.com/science/articl
e/pii/S0142961200001010.
- J. R. Fuchs, B. A. Nasseri, and J. P. Vacanti.
(August 2001). Tissue engineering: a 21st
century solution to surgical reconstruction.
Ann Thorac Surg. [online]. 72(2), pp. 577-
591. Available:
http://www.sciencedirect.com/science/articl
e/pii/S000349750102820X.
- A. Persidis. (1999). Tissue engineering. Nat.
Biotechnol. [online]. 17(5), pp. 508-510.
Available:
http://www.nature.com/nbt/journal/v17/n5/f
ull/nbt0599_508.html.
- L. G. Griffith and G. Naughton. (08
February 2002). Tissue engineering—
current challenges and expanding
opportunities. Science. [online]. 295(5557),
pp. 1009-1014. Available:
http://science.sciencemag.org/content/295/5
557/1009.full.
- L. G. Cima, J. P. Vacanti, C. Vacanti, D.
Ingber, D. Mooney, and R. Langer. (1 May
1991). Tissue engineering by cell
transplantation using degradable polymer substrates. J. Biomech. Eng. [online].
113(2), pp. 143-151. Available:
http://biomechanical.asmedigitalcollection.a
sme.org/article.aspx?articleid=1398574.
- A. G. Mikos, Y. Bao, L. G. Cima, D. E.
Ingber, J. P. Vacanti, and R. Langer.
(September 1993). Preparation of
poly(glycolic acid) bonded fiber structures
for cell attachment and transplantation. J.
Biomed. Mater. Res. [online]. 27(2), pp.
183-189. Available:
http://onlinelibrary.wiley.com/doi/10.1002/j
bm.820270207/pdf.
- K. Rezwana, Q. Z. Chena, J. J. Blakera, and
A. R. Boccaccinia. (June 2006).
Biodegradable and bioactive porous
polymer/inorganic composite scaffolds for
bone tissue engineering. Biomaterials.
[online]. 27(18), pp. 3413–3431. Available:
http://www.sciencedirect.com/science/articl
e/pii/S0142961206001232.
- S. Joji, H. Muneshige, and Y. Ikuta.
(October 1999). Experimental study of
mechanical microvascular anastomosis with
new biodegradable ring device. British
Journal of Plastic Surgery. [online]. 52(7),
pp. 559–564. Available:
http://www.sciencedirect.com/science/articl
e/pii/S0007122699931314.
- E. L. Chaikof, H. Matthew, J. Kohn, A. G.
Mikos, G. D. Prestwich, and C. M. Yip.
(June 2002). Biomaterials and scaffolds in
reparative medicine. Ann NY Acad Sci.
[online]. 961, pp. 96–105. Available:
http://onlinelibrary.wiley.com/doi/10.1111/j
.1749-6632.2002.tb03057.x/abstract.
- O. C. Farokhzad, J. D. Dimitrakov, J. M.
Karp, A. Khademhosseini, M. R. Freeman,
and R. Langer. (September 2006). Drug
Delivery Systems in Urology-Getting
“Smarter”. Urology. [online]. 68(3), pp.
463–469.
doi:10.1016/j.urology.2006.03.069.
Available:
http://www.sciencedirect.com/science/articl
e/pii/S0090429506004997.
- A. J. Gavasane and H. A. Pawar. (22
September 2014). Synthetic Biodegradable
Polymers Used in Controlled Drug Delivery
System: An Overview. Clinical
Pharmacology & Biopharmaceutics.
[online]. 3(2), pp. 1-7. Available: https://www.omicsgroup.org/journals/synth
etic-biodegradable-polymers-used-incontrolled-drug-delivery-system-2167-
065X.1000121.php?aid=31480.
- V. B. Kotwal, M. Saifee, N. Inamdar, and K.
Bhise. (2007). Biodegradable polymers:
Which, when and why?. Indian Journal of
Pharmaceutical Sciences. [online]. 69(5),
pp. 616-625. Available:
http://www.ijpsonline.com/articles/biodegra
dable-polymers-which-when-and-why.html.
- R. Langer. (30 April 1998). Drug delivery
and targeting. Nature. [online]. 392(6679),
pp. 5-10. Available:
https://www.ncbi.nlm.nih.gov/pubmed/957
9855.
- H. Rosen and T. Abribat. (May 2005). The
rise and rise of drug delivery. Nat. Rev. Drug
Discov. [online]. 4, pp. 381-385. Available:
http://www.nature.com/nrd/journal/v4/n5/fu
ll/nrd1721.html.
- J. H. Park, M. G. Allen, and M. R. Prausnitz.
(May 2006). Polymer Microneedles for
controlled-release drug delivery.
Pharmaceutical Research. [online]. 23(5),
pp. 1008-1019. Doi:10.1007/s11095-006-
0028-9. Available:
http://link.springer.com/article/10.1007%2F
s11095-006-0028-9.
- S. Kempe, H. Metz, and K. Mäder. (24
September 2008). Do in situ forming
PLG/NMP implants behave similar in vitro
and in vivo? A non-invasive and quantitative
EPR investigation on the mechanisms of the
implant formation process. Journal of
Controlled Release. [online]. 130(3), pp.
220–225. Available:
http://www.sciencedirect.com/science/articl
e/pii/S0168365908003386.
- M. R. Shaik, M. Korsapati, and D. Panati.
(24 November 2012). Polymers in
Controlled Drug Delivery Systems.
International Journal of Pharma Sciences.
[online]. 2(4), pp. 112-116. Available: http://ijps.aizeonpublishers.net/content/201
2/4/ijps112-116.pdf.
- M. D. T. Yasukawa, H. Kimurab, Y.
Tabatac, and Y. Ogurab. (31 October 2001).
Biodegradable scleral plugs for vitreoretinal
drug delivery. Advanced Drug Delivery
Reviews. [online]. 52(1), pp. 25–36.
Available:
http://www.sciencedirect.com/science/articl
e/pii/S0169409X01001922.
- C. G. Pitt, M. M. Gratzl, A. R. Jeffcoat, R.
Zweidinger, and A. Schindler. (December
1979). Sustained drug delivery systems. II.
Factors affecting release rates from poly(ecaprolactone)
and related biodegradable
polymers. J. Pharm. Sci. [online]. 68(12),
pp. 1534–1538. Available:
http://www.sciencedirect.com/science/articl
e/pii/S0022354915429557.
- M. S. Hora, R. K. Rana, J. H. Nunberg, T. R.
Tice, R. M. Gilley, and M. E. Hudson.
(November 1990). Release of human serum
albumin from poly(lactide-co-glycolide)
microspheres. Pharm. Res. [online]. 7(11),
pp. 1190–1194. Available:
http://link.springer.com/article/10.1023/A:1
015948829632.
- L. M. Sanders, J. S. Kent, G. I. Mcrae, B. H.
Vickery, T. R. Tice, and D. H. Lewis.
(September 1984). Controlled release of a
luteinizing hormone-releasing hormone
analogue from poly(D,L-lactide-coglycolide)
microspheres. J. Pharm. Sci.
[online]. 73(9), pp. 1294–1297. Available:
http://www.sciencedirect.com/science/articl
e/pii/S0022354915463154.
- D. A. Wood. (November 1980).
Biodegradable drug delivery systems.
International Journal of Pharmaceutics.
[online]. 7(1), pp. 1-18. Available:
http://www.sciencedirect.com/science/articl
e/pii/0378517380900940.