Burcu YÜKSEL, Fikriye POLAT, Tuğba Büşra BAYRAM

Investigation of Neuregulin-1 Gen rs6994992 Polymorphism in Gifted Students in Turkish Population

Aim: The aim of this study is to investigate whether neuregulin-1 gene (NRG1) rs6994992 polymorphism has any role in gifted students in Turkish population.Methods: During the 2017-2018 academic year, 97 gifted students (experiment group) and 99 students with normal development (control group) attending 5th grade of different public schools participated in the research. Genomic DNA was extracted from the oral epithelial cells. Genotyping of the molecular variant was performed by Polymerase Chain Reaction- Agarose gel electrophoresis-DNA sequencing techniques.Results: Genotype difference in gifted students was estimated as odds ratio and 95% confidence interval using binary logistic regression models. While the frequencies of CC (wild type), CT (heterozygous), TT (polymorphic type) genotypes were 33.0, 53.6 and 13.4%for the experimental group, respectively, they were observed as 33.0, 60.0 and 7.0% in the control group. In the Turkish population, no association could be detected for both genotype and allele distribution for NRG1 rs6994992 C/T polymorphism between gifted and control group (OR: 0.538, CI: 0.190-1.525, p = 0.244).Conclusion: According to the results of our study, there was no relationship between NRG1 rs6994992 polymorphism and gifted students in the Turkish population.Keywords: NRG1, rs6994992, SNP, gifted, intelligence, Turkish population

PDF

___

[1] Y. Yarden and M. X Sliwkowski, “Untangling the ErbB signalling network,” Nat. Rev. Mol. Cell Biol., vol. 2, pp. 127- 137, 2001.
[2] M. A. Olayioye, R. M. Neve, and H.A. Lane, “The ErbB signaling network: receptor heterodimerization in development and cancer,” EMBO J., vol. 19, pp. 3159- 3167, 2000.
[3] D. L. Falls, “Neuregulins: functions, forms and signaling strategies,” Exp. Cell Res., vol. 284, pp.14-30, 2003.
[4] M. Xu, X. Wu, B. Jie et al., “Neuregulin-1 protects myocardial cells against H2O2- induced apoptosis by regulating endoplasmic reticulum stress,” Cell Biochem. Funct., vol. 32, pp. 464-469, 2014.
[5] T. Cvetkovic, J. Stankovic, S. Najman et al., “Oxidant and antioxidant status in experimental rat testis after testicular torsion/detorsion,” Int. J. Fertil. Steril., vol. 9, pp. 121-128, 2015.
[6] S.A. Crone and K. F. Lee, “Gene targeting reveals multiple essential functions of the neuregulin signaling system during development of the neuroendocrine and nervous systems,” Ann. N. Y. Acad Sci. vol. 971, pp. 547-553, 2002.
[7] S. Britsch, “The neuregulin-I/ErbB signaling system in development and disease,” Springer Science & Business Media, vol. 190, 2002.
[8] S. Ağım, “Schizophrenia: another emphasis Of Erbb4 And NRG1 impact on disease development”. Graduate Program in Molecular Biology and Genetics, Boğaz൴ç൴ University, 2012.
[9] J. Yoo, H. Kim, S. Yoo, et al., “Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons,” Anat. Cell Biol., vol. 52, pp. 462-468, 2019.
[10] L. Luo, L. Li, M. Guo et al., “Genetic variation in NRG 1 gene and risk of posttraumatic stress disorders in patients with hepatocellular carcinoma,” J. Clin. Lab. Anal., vol. 34, no. 5, e23187, 2020.
[11] X. Yin, Y. Chen, and G. Tu, Neuregulin‐ 1 impacting bone marrow mesenchymal stem cell migration is conducive to functional recovery following spinal cord injury,” Mol. Med. Rep., vol. 20, pp. 41-48, 2019.
[12] URL-1: http://www.primer3.ut.ee/, Visitdate: 09.10.2018.
[13] URL-2: http://www.tufts.edu/~mcourt01/Docume nts/Court%20lab%20%20HW%20calcula to r.xls., Visit date: 08.09.2019.
[14] S. Kér൴, “Genes for psychos൴s and creat൴v൴ty: a promoter polymorph൴sm of the neuregul൴n 1 gene ൴s related to creat൴v൴ty ൴n people w൴th h൴gh ı̇ ntellectual achievement,” Psychol. Sci. vol. 20, pp.1070-1073, 2009.
[15] S.H. Carson, J.B. Peterson, and D.M. Higgins, “Reliability, validity, and factor structure of the creative achievement questionnaire,” Creativ. Res. J, vol. 17, no. 1, pp. 37-50, 2005.
[16] A. Dietrich, “The cognitive neuroscience of creativity,” Psychonomic Bulletin & Review, vol.11, pp.1011–1026, 2004.
[17] J.L. Yokley, K.M. Prasad, K.V. Chowdari et al., “Genetic associations between neuregulin-1 SNPs and neurocognitive function in multi generational, multiplex schizophrenia families,” Psychiatr. Gene., vol. 22, pp. 70-81, 2012.
[18] J. Durdiakova, S. Lakatosova, A. Kubranska et al., “Mental rotation in intellectually gifted boys is affected by the androgen receptor CAG repeat polymorphism,” Neuropsychologia., vol. 51, pp. 1693–1698, 2013.
[19] P. Celec, D. Tretinarova, G. Minarik et al., “Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys,” PLoS ONE, vol. 8, no. 1, e54751, 2013.