Havva Erdem, Yasemin Kaya, Ali Aslan, Soner Çankaya

Kronik Kolesistit Hastalarında Safra Kesesi IGF-1 Ekspresyonu Ve Kan CRP Düzeyi İlişkisi

Amaç Bu araştırmada, çeşitli biyokimyasal parametreler ve safra kesesi insülin benzeri büyüme faktörü-1 (IGF-1) ekspresyonu arasındaki ilişkibiyokimyasal ve patolojik yöntemlerle incelenmiştir. ( Sakarya Tıp Dergisi 2018, 8(3):782-787 )Gereç veYöntemler1 Ocak 2017- 31 Ocak 2018 tarihleri arasında Ordu Eğitim Araştırma Hastanesi’nde kronik kolesistit tanısı alan hastalara ait tıbbi kayıtlarretrospektif olarak incelendi. Hastaların çeşitli biyokimyasal parametreleri çalışıldı. Kronik kolesistit nedeniyle opere edilen hastalardan eldeedilen kolesistektomi materyalinde immünhistokimyasal yöntemle IGF-1 antikoru uygulandı.Bulgular Patolojik incelemede IGF-1 ekspresyonunun izlendiği gruptaki en belirgin biyokimyasal değer C-reaktif protein (CRP) yüksekliği olaraksaptandı.Sonuç Safra kesesi IGF-1 ekspresyonu ve infl amasyon ilişkisini düşündüren bu bulguların farklı yöntemlerle doğrulanması kronik kolesistit gelişimive kolesistit-kanser ilişkisi üzerine yeni ufuklar açabilir.

The Relation Among Blood CRP Level And Gallbladder IGF-I Expression İn Patients With Chronic Cholecystitis

Objective In the present study, the relation between certain biochemical parameters and gallbladder insülin-like growth factor I (IGF-1) expression was investigated with pathological and biochemical methods. ( Sakarya Med J 2018, 8(3):782-787 ). Materials and Methods The records of patients who administrated to Ordu Education and Research Hospital between 1 January 2017-31 January 2018 with the diagnosis of chronic cholecystitis were examined retrospectively. Certain biochemical parameters of the patients were studied. In addition IGF-1 antibody was applied to cholecystectomy specimens with immunohistochemical method. Results In pathological evaluation, the group exhibiting positive IGF-1 staining showed high C-reactive protein (CRP) values. Conclusion Future confi rmation of these fi ndings of IGF-1 expression and infl ammation connection could lead new directions through cholecystitis development and cholecystitis-cancer link.

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1. Ateş B, Ünal İ. Kolesistit, safra taşları, risk faktörleri ve beslenme ile ilişkisi. Güncel Gastroenteroloji 2016;20:317-321.
2. Shaffer EA. Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century? Curr Gastroenterol Rep. 2005;7:132–140.
3. Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver 2012;6:172–87.
4. Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H et al. Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. Cancer Sci. 2012;103:252-261.
5. Suzuki H, Roa JC, Kawamoto T, Ishige K, Wistuba II, Li D et al. Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients. Molecular And Clinical Oncology 2015;3:464-470,
6. Sandberg AA. Diagnosis and Management of Gallbladder Cancer. N Am J Med Sci. 2012 Jul; 4(7): 293–299.
7. Pollak MN, Schernhammer ES, Hankinso SE. Insulin-like growth factors and neoplasia. Nat Rev Cancer 2004;4:505–18.
8. Foulstone E, Prince S, Zaccheo O, et al. Insulin-like growth factor ligands, receptors and binding proteins in cancer. J Pathol 2005;205:145–53.
9. Mauro L, Surmacz E. IGF-I receptor, cell–cell adhesion, tumour development and progression. J Mol Histol 2004;35:247–53.
10. Kornprat P, Rehak P, Ruschoff J, Langner C. Expression of IGF-I, IGFII, and IGF-IR in gallbladder carcinoma. A systematic analysis including primary and corresponding metastatic tumours. J Clin Pathol 2006;59:202–206.
11. Sokolovi� A, Rodriguez-Ortigosa CM, Bloemendaal L, Elferink RPJO, Prieto J, Bosma PJ. Insulin-like growth factor 1 enhances bile-duct proliferation and fi brosis in Abcb4−/− mice. Biochimica et Biophysica Acta 2013;1832:697–704.
12. Renehan AG, Frystyk J, Flyvbjerg A. Obesity and cancer risk: the role of the insülin-IGF axis. Trends Endocrinol Metab. 2006 Oct;17:328-36. 13. Cohen DH ve LeRoith D. Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocrine-Related Cancer 2012;19:F27– F45
14. Floros T, Philippou A, Bardakostas D, Mantas D, Koutsilieris M. The growth endocrine axis and infl ammatory responses after laparoscopic cholecystectomy. Hormones (Athens). 2016;15:73-80.
15. Shrivastava AK, Singh HV, Raizada A, Singh SK. C-reactive protein, infl ammation and coronary heart disease. The Egyptian Heart Journal 2015;67:89–97.
16. Gurbulak EK, Gurbulak B, Akgun IE, Duzkoylu Y, Battal M, Celayir MF et al. Prediction of the grade of acute cholecystitis by plasma level of C-reactive protein. Iran Red Cresccent Med J.2015;17:e28091
17. Başer M, Maviş O, Özgür R, Özdemir AA, Özkeskin A, Küçükdemirci Ö et al. Diyabetik Obez Hastalarda Obezitenin Yüksek Duyarlıklı C-Reaktif Protein (Hs-CRP) ile İlişkisi. Haseki Tıp Bülteni 2013; DOI: 10.4274/ Haseki.1056