Fatma Behice SERİNKAN CİNEMRE, Nurten Bahtiyar BAHTİYAR, Esra ERTAN, Sevgin DEĞİRMENCİOĞLU, Nilgun DİLAVEROĞLU, Ayse ERDOGAN ÇAKAR, Hakan CİNEMRE, Birsen AYDEMİR

Hashimoto Tiroiditli Hastalarda Bakır, Demir, Çinko, Selenyum Düzeyleri ve Cu/Se, Cu/Zn, Fe/Se, Fe/Zn Oranlarının Araştırılması

Amaç: Bu çalışmanın amacı, Hashimoto tiroiditi (HT) etiyopatogenezinde selenyum (Se) demir (Fe), çinko (Zn) ve bakır (Cu) eser elementlerinin serum düzeylerindeki ve oranlarındaki değişimlerinin belirlenmesi ve bu parametreler arasındaki olası ilişkinin değerlendirilmesidir. Gereç ve Yöntem: Çalışma 35 HT ve 28 sağlıklı birey ile gerçekleştirildi. Çalışmaya dahil edilen tüm bireylere ait serum Se, Zn, Cu ve Fe düzeyleri indüktif eşleşmiş plazma optik emisyon spektrofotometresi (ICP-OES, Thermo iCAP 6000) ile ölçüldü. Bulgular: Serum Se, Fe, Cu ve Zn düzeylerinin HT grubunda kontrol grubuna göre anlamlı derecede azaldığı saptandı (sırasıyla p<0,001, p<0,001, p<0,05 ve p<0,001). Cu/Zn ve Cu/Se oranlarının HT grubunda arttığı görüldü. Ayrıca, HT grubunda Cu düzeyleri ile Cu/Zn oranı; Fe/Se ile Cu/Se oranları; Fe/Zn ile Fe/Se oranları; Fe düzeyleri ile Fe/Se ve Fe/Zn oranları arasında pozitif korelasyon olduğu belirlendi. Se düzeylerinin Cu/Se ve Fe/Se oranları ile negatif korelasyon gösterdi. Zn düzeyleri de Cu/Zn oranı ile negatif korelasyon göstermiştir. Sonuç: Çalışmamızın sonuçları, eser element düzeyleri ve oranlarının HT etiyopatogenezinde yer aldığını göstermektedir. Hastalığın altta yatan mekanizmaları ile eser element ve oranlarının etkileşiminin aydınlatılması için daha ileri çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler:

Hashimoto tiroiditi, Se, Zn, Cu, Fe, Cu/Se, Cu/Zn, Fe/Se

Investigation of the Levels of Copper, Iron, Zinc, Selenium and Ratios of Cu/Se, Cu/Zn, Fe/Se, Fe/Zn in Patients with Hashimoto Thyroiditis

Objective Our aim was to investigate relationship of serum selenium(Se), zinc(Zn), copper(Cu) and iron(Fe) levels and ratios of Cu/Se, Cu/Zn, Fe/Seand Fe/Zn with etiopathogenesis of Hashimoto Thyroiditis (HT). ( Sakarya Med J, 2018, 8(2):285-291 ).Materials andMethodsThirty-fi ve patients with HT and 28 healthy controls were included. Serum Se, Fe, Cu and Zn were measured by inductively coupled plasmaoptical emission spectrometry (ICP-OES) and Cu/Se, Cu/Zn, Fe/Se and Fe/Zn ratios were calculated.Results Serum selenium, iron, copper and zinc levels were signifi cantly decreased in HT patients group (p<0,001, p<0,001, p<0,05 and p<0,001,respectively). However, Cu/Zn and Cu/Se ratios were signifi cantly increased in HT patients (p<0,05). In HT patients, there were positivecorrelations between Cu and Cu/Zn; between Fe/Se and Cu/Se ratios; between Fe/Zn and Fe/Se ratios (p<0,01). In the same group, Felevels were also positively correlated with Fe/Se and Fe/Zn ratios (p<0,01). However, Se level was negatively correlated with Cu/Se and Fe/Se ratios (p<0,01). Additionally, Zn was negatively correlated with Cu/Zn ratio (p<0,01).Conclusion Our results showed that together with trace element levels and ratios were involved in HT etiopathogenesis. Details of mechanisms underlying the disease should be clarifi ed with further studies.

Keywords:

Hashimoto Thyroiditis Se, Zn, Cu, Fe, Cu/Se, Cu/Zn, Fe/Se, Fe/Zn,

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