Gonartrozlu Hastalarda Trigliserit Glikoz İndeksi ile Nötrofil Lenfosit Oranı Arasındaki İlişki

Amaç: Bu çalışmada, bu göstergelerin gonartroz gelişimindeki rolünü araştırmak için Trigliserit Glikoz, Nötrofil Lenfosit Oranı ve gonartroz hastalığı arasındaki ilişki araştırıldı. Yöntem: Çalışmamızda 01.06.2022-01.10.2021 tarihleri arasında ortopedi kliniğimizde takip edilen 50-84 yaş arası 141 hasta retrospektif olarak incelendi. Katılımcılar iki kontrol ve çalışma grubuna ayrıldı. Gonartroz tanısı alan katılımcılar çalışma grubuna, sağlıklı kontroller kontrol grubuna dahil edildi. Hastaların demografik özellikleri ve biyokimyasal verileri hasta dosyalarından ve elektronik kayıtlardan toplandı. Bulgular: Hastaların yaşı 54±12.5 (18-75) idi. Çalışmamızdaki biyokimyasal parametrelerden açlık safra taşı olan olgularda plazma glukozu 124,6 ± 24,5 mg/dL, trigliserit 198.3 ± 36,8 mg/dL, insülin 16,5 ± 5,6 uIU/mL, HOMA-IR 4 düzeyi ,8± 1.2, hepsinde kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksekti (p=0.001). TGYI gruba göre anlamlı farklılık göstermektedir (p<0.05). Gonartroz grubundakilerin ortalaması 4,3±0,22 iken kontrol grubundakilerin ortalaması 4,21±0,08 idi. NEUCRP gruba göre anlamlı farklılık göstermektedir (p<0.05). Gonartroz grubundakilerin ortalaması 3.02±5.55 iken kontrol grubundakilerin ortalaması 1.37±0.53 idi. Sonuç: Sonuçlar, Trigliserit Glikoz İndeksi ve Nötrofil Lenfosit Oranı gibi metabolik sendrom indeksleri ile gonartroz arasında anlamlı bir ilişki olduğunu göstermiştir.

Anahtar Kelimeler:

Trigliserit Glikoz İndeksi, Nötrofil Lenfosit Oranı, Gonartroz

Association Between Triglyceride Glucose Index and Neutrophil Lymphocyte Ratio in Patients with Gonarthrosis

Aim: This study investigated the relationship between Triglyceride Glucose, Neutrophil Lymphocyte Ratio, and gonarthrosis disease to investigate the role of these indicators in developing gonarthrosis. Method: Our study retrospectively investigated 141 patients aged between 50-84 years old who underwent follow-up in our orthopedic clinic between 01.06.2022-01.10.2021. The participants were divided into two control and study groups. Participants diagnosed with gonarthrosis were included in the study group, and healthy controls were included in the control group. Demographic characteristics of the patients and biochemical data were collected from patient files and electronic records. Results: The age of the patients was 54±12.5 (18-75) years. Among the biochemical parameters in our study, in cases with fasting gallstones, plasma glucose is 124.6 ± 24.5 mg/dL, triglyceride 198.3 ± 36.8 mg/dL, insulin 16.5 ± 5.6 uIU/mL, HOMA-IR 4 The level of .8±1.2 was statistically significantly higher in all of them compared to the control group (p=0.001). TGYI shows a significant difference according to the group (p<0.05). The mean of those in the gonarthrosis group was 4.3±0.22, while the mean of those in the control group was 4.21±0.08. NEUCRP shows a significant difference according to the group (p<0.05). While the mean of those in the gonarthrosis group was 3.02±5.55, the mean of those in the control group was 1.37±0.53. Conclusion: Results showed a significant association between metabolic syndrome indexes, such as Triglyceride Glucose Index and Neutrophil Lymphocyte Ratio, and gonarthrosis.

Keywords:

Triglyceride Glucose Index, Neutrophil Lymphocyte Ratio, Gonarthrosis,

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1. Klymas I, Khimion L. AB0354 The Prevalence of Metabolic Syndrome and Hepatobiliary System Demage in Rheumatoid Arthritis Patients. BMJ Publishing Group Ltd; 2015.
2. Pengo V, Prandoni P. Abstracts of the 25th Biennial International Congress on Thrombosis. 2018.
3. Morgunova ZA, Uryasyev OM. Clinical and laboratory peculiarities of combined clinical course of metabolic and articular syndromes. IP Pavlov Russian Medical Biological Herald. 2018;26(2):229-37.
4. Korochina K, Korochina I, Chernysheva T. Clinical and morphological features of age-related, posttraumatic and metabolic phenotypes of late stage knee osteoarthritis. Osteoarthritis and Cartilage. 2020;28:S390-S1.
5. Korochina K, Chernysheva T, Korochina I, Tenchurina L, Kuznetsov G. CLINICAL MANIFESTATIONS AND COMORBIDITY IN PATIENTS WITH AGE-RELATED, POSTTRAUMATIC, METABOLIC AND MIXED GENESIS OF GONARTHROSIS. Медицинский вестник Башкортостана. 2021:20.
6. Borges PA, Almeida MHJD, Araújo LM, Fukuyama JM, Umada FY, Arab MGL. Correlation between Ahlbäck classification and gonarthrosis risk factors. Acta Ortopédica Brasileira. 2018;26:240-3.
7. Wallace TC. Dietary Bioactives and Bone Health: MDPI AG-Multidisciplinary Digital Publishing Institute; 2018.
8. Yakimenko O, Bogdan N. Effect of the drug from soybean and avocado on the course of osteoarthrosis of the knee joints with concomitant metabolic syndrome in women in the menopausal period. Technology transfer: innovative solutions in medicine. 2017:3-5.
9. Plaza Florido AA. Exercise, fitness and health in childhood obesity: a focus on transcriptomics, epigenomics, and proteomics. 2022.
10. Yildiz K, Cadirci K, editors. Gonarthrosis, Diabetes Mellitus (Type 1 or 2), Leptin, Nesfatin-1. Endocrine Abstracts; 2017: Bioscientifica.
11. Jarecki J, Małecka-Massalska T, Polkowska I, Potoczniak B, Kosior-Jarecka E, Szerb I, et al. Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis. Journal of clinical medicine. 2021;10(6):1263.
12. Charles-Lozoya S, Treviño-Báez JD, Ramos-Rivera JA, Rangel-Flores JM, Tamez-Montes JC, Brizuela-Ventura JM. Metabolic syndrome and other factors associated to gonarthrosis. Gac Med Mex. 2017;153:701-5.
13. Muraki S, Oka H, Akune T, Mabuchi A, En-Yo Y, Yoshida M, et al. Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. Osteoarthritis and cartilage. 2009;17(9):1137-43.
14. Aziz A, ALTUN E. The Relationship of Inflammatory Indicators and Metabolic Syndrome with Gonarthrotic Cartilage Degeneration: A Novel Glance. Acta Medica Alanya. 2021;5(2):144-9.
15. Paul AK, Jahan R, Paul A, Mahboob T, Bondhon TA, Jannat K, et al. The role of medicinal and aromatic plants against obesity and arthritis: A review. Nutrients. 2022;14(5):985.
16. Oreiro-Villar N, Fernandez-Moreno M, Cortes-Pereira E, Vazquez-Mosquera M, Relaño S, Pertega S, et al. SAT0535 Impact of the metabolic syndrome on the prevalence, severity incidence and progression of knee osteoarthritis. BMJ Publishing Group Ltd; 2017.
17. Talbi S, Azzouzi H, Aradoini N, Lazrak F, Keita S, Errasfa M, et al. OP0107 Does Metabolic Syndrome or its Individual Components Affect Pain and Function in Knee Osteoarthritis Women? : BMJ Publishing Group Ltd; 2015.
18. Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, et al. Evidence for a key role of leptin in osteoarthritis. Arthritis & Rheumatism. 2003;48(11):3118-29.
19. Farnaghi S, Crawford R, Xiao Y, Prasadam I. Cholesterol metabolism in pathogenesis of osteoarthritis disease. International journal of rheumatic diseases. 2017;20(2):131-40.
20. Papathanasiou I, Anastasopoulou L, Tsezou A. Cholesterol metabolism related genes in osteoarthritis. Bone. 2021;152:116076.
21. García-Gil M, Reyes C, Ramos R, Sanchez-Santos M, Prieto-Alhambra D, Spector TD, et al. Serum lipid levels and risk of hand osteoarthritis: the chingford prospective cohort study. Scientific Reports. 2017;7(1):1-7.
22. Yıldız K, Boy F. Serum progranulin to TNF-α ratio in patients with gonarthrosis. Acta Orthopaedica et Traumatologica Turcica. 2021;55(3):235-8.
23. Stommel G, Schuehlein S, Schuehlein K-H, Rainsford K. Therapeutic effects of Ribunucleinate (Ribonucleotides) in immuno-inflammatory and arthritic diseases. Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases. 2015:35-89.
24. Lepetsos P, Papavassiliou AG. ROS/oxidative stress signaling in osteoarthritis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2016;1862(4):576-91.