COVID-19 Hastalığında Probiyotiklerin Rolü, Önemi ve Kullanımı

Aralık 2019 yılında Çin’in Wuhan şehrinde etiyolojisi bilinmeyen bir pnömoni salgını tüm dünyaya yayıldı. Bu salgın yeni tip koronavirüs olan Şiddetli Akut Solunum Sendromu Coronavirus 2 (SARS-CoV-2) olarak adlandırıldı ve hastalığa COVID-19 adı verildi. Dünya Sağlık Örgütü (DSÖ) tarafından global pandemi ilan edildi. COVID -19 hastalığında ateş, öksürük, krup, nefes darlığı, koku alamama gibi semptomların yanında gastrointestinal sistem hastalıkların (GİS) semptomları da bildirilmiştir. SARS-CoV-2, akciğerlerin alveolar epitel hücrelerinde bulunan ACE-2 reseptörlerine bağlanarak pnömoniye neden olur. Ayrıca sadece akciğer hücreleri değil bağırsak epitel hücrelerinin (özellikle enterositler) de ACE-2 reseptörlerini eksprese ettiği gözlenmiştir. Son zamanlarda COVID-19 hastalarının dışkı materyalinde de SARS-CoV-2 RNA izole edilmiştir. Bu durum COVID-19 ve GİS arasında bir ilişki olabileceğini göstermektedir. Şu anda, COVID-19 için kullanılan ilaç ve birden fazla aşı mevcuttur ancak aşı üretimi, aşının etkinliği, saklama koşulları ve taşınmasındaki aksaklıklardan dolayı viral yükü azaltmak için alternatif tedaviler araştırılmaktadır. Probiyotikler, belirli dozlarda insan sağlığı üzerine faydalı etkileri olan canlı mikroorganizmalar olarak tanımlanmaktadır. Bilimsel çalışmalar probiyotiklerin antiviral özelliğini ve genel bağışıklığı güçlendirici etkisini ortaya koymuştur. Bu derleme probiyotiklerin COVID-19 hastalığındaki rolünü, SARS-CoV-2 enfeksiyonu ve mikrobiyota arasındaki olası ilişkiyi tartışmayı amaçlamaktadır.

Anahtar Kelimeler:

bağırsak-akciğer aksı, COVID-19, mikrobiyota, probiyotikler

THE ROLE, IMPORTANCE AND USE OF PROBIOTICS IN COVID-19 DISEASE

In December 2019, a pneumonia epidemic of unknown etiology spread to the whole world in Wuhan, China. This epidemic was named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the new type of coronavirus, and the disease was named COVID-19. It has been declared a global pandemic by the World Health Organization (WHO). In COVID-19 disease, symptoms such as fever, cough, croup, shortness of breath, and inability to smell have been reported, as well as symptoms of gastrointestinal system diseases (GIS). SARS-CoV-2 causes pneumonia by binding to ACE-2 receptors found in alveolar epithelial cells of the lungs. It has also been observed that not only lung cells but also intestinal epithelial cells (especially enterocytes) express ACE-2 receptors. Recently, SARS-CoV-2 RNA has also been isolated in the stool material of COVID-19 patients. This indicates that there may be a relationship between COVID-19 and GIS. Currently, there are drugs and multiple vaccines used for COVID-19, but alternative treatments are being explored to reduce viral load due to insufficiency in vaccine production, vaccine efficacy, storage conditions and transportation. Probiotics are defined as living microorganisms that, in certain doses, have beneficial effects on human health. Scientific studies have revealed the antiviral properties and general immunity-enhancing effects of probiotics. This review aims to discuss the role of probiotics in COVID-19 disease, the possible relationship between SARS-CoV-2 infection and the microbiota.

Keywords:

COVID-19, gut-lung axis, microbiota, probiotics,

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