The Effects of Sodium Fluorescein Dyeing of Metastatic Brain Tumors on Surgical Outcomes Under Microsurgical Operation

Aim: We investigated the reflection of tumor dyeing (staining), an auxiliary technique for the resection of metastases, which are the most prevalentgroup among brain tumors, via microsurgery.Materials and Methods: Twenty one patients, who were operated under surgical white light, and 27 patients who were operated via sodiumfluorescein (FL) dyeing (staining) due to metastatic brain tumors were evaluated retrospectively. The gross total resection (GTR) rates, surgical time,amount of blood loss, and the duration of hospital stay for both groups were compared. The contribution of FL dyeing (staining) to surgery wasevaluated for the group with FL dyeing (staining).Results: The study comprised of 48 patients in total. The median age of patients was 61.5 years (minimum: 20, maximum: 80), the average age was59.1±11.8 years. There was no difference between the group with FL dyeing and the one without dyeing in terms of gender, age, tumor size, GTRrates and surgical time. Blood loss and duration of hospital stay in the FL used group was significantly less. In the group with FL dyeing (staining)(92.5%), this method contributed to the surgery by giving yellow highlights.Conclusion: It has been found out that in the surgery of metastatic brain tumors, FL dyeing decreases the blood loss, shortens the surgical time, andaids in the differentiation of tumor glial tissue.

Metastatik Beyin Tümörlerinin Mikrocerrahi Yönetiminde Sodyum Fluorescein Boyamanın Cerrahi Sonuçlara Etkileri

Amaç: Beyin tümörleri içerisinde en sık görülen grup olan metastazların mikrocerrahi ile çıkartılmasında yardımcı bir teknik olan tümör boyamanın cerrahi sonuçlarımıza yansımasını araştırdık. Gereç ve Yöntem: Metastatik beyin tümörü nedeni ile mikrocerrahi yöntem ile beyaz ışık altında opere edilen 21 hasta ve sodyum fluorescein (FL) boyama kullanılan 27 hasta retrospektif olarak değerlendirildi. Her iki grubun gross total rezeksiyon (GTR) oranları, cerrahi süreleri, kan kaybı miktarları, hastanede kalış süreleri karşılaştırıldı. FL kullanılan grupta boyamanın cerrahiye yaptığı katkı değerlendirildi. Bulgular: Çalışmaya toplamda 48 hasta alındı. Hastaların medyan yaşı 61,5 (minimum: 20 maksimum: 80) yıl, ortalama yaşı 59,1±11,8 yıl idi. FL kullanılmayan ve kullanılan gruplarda cinsiyet, yaş, tümör büyüklüğü, GTR oranları ve cerrahi süre açısından fark yoktu. FL kullanılan grupta kan kaybı miktarları ve hastanede kalış süresi belirgin şekilde azdı. FL kullanılan grupta yirmi beş hastada (%92,5) FL sarı röfle vererek cerrahiye katkı sağlamıştır. Sonuç: Metastatik beyin tümörlerinin cerrahisinde FL boyama kan kaybını ve cerrahi süreleri azaltmakta, tümör glial doku ayrımında cerraha yardımcı olmaktadır.

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