Esma TÜRKMEN BEKMEZ

KÜÇÜK HÜCRELİ AKCİĞER KANSERİNDE PROGNOSTİK NUTRİSYONEL İNDEKSİN PROGNOZ ÜZERİNE ETKİSİ: TEK MERKEZ DENEYİMİ

Amaç: Küçük hücreli akciğer kanseri hastalarında prognostik nutrisyonel indeks parametresinin genel sağkalım üzerine etkisiniaraştırmaktır.Materyal ve Metot: Kliniğimizde takip edilen 52 küçük hücreli akciğer kanseri hastasının dosyaları retrospektif olarak incelendi. Tanıanındaki albümin ve lenfosit değeri kullanılarak prognostik nutrisyonel indeks (PNİ) hesaplandı. PNİ ile genel sağkalım arasındaki ilişkiincelendi.Bulgular: Hastaların 47’si (%87) erkek, 5’i kadındı. Yaş ortancası 62.9 (48-82) idi. Ortanca PNİ değeri 45 idi. Median progresyonsuzsağkalım süresi 6.9 ay, median genel sağkalım süresi 8.7 ay idi.Çok değişkenli analizde, sınırlı evre hastalık ve PNİ≥45 olması genelsağkalım için bağımsız iyi prognostik faktör olarak saptandı. Genel sağ kalımla cinsiyet, yaş, LDH durumu arasında ilişki saptanmadı.Sonuç: Çalışmamızda prognostik nutriyonel indeks ve sınırlı evre hastalığın genel sağkalım açısından iyi prognostik bir faktör olduğunusaptadık.

The Effect of Prognostic Nutritional Index on Prognosis in Small Cell Lung Cancer: Single Center Experience

Aim: The aim of this study is to investigate the effect of prognostic nutritional index parameter on overall survival in small cell lung cancer patients. Materials and Methods: Fifty-two small cell lung cancer patients who were diagnosed in our clinic were reviewed retrospectively. Prognostic nutritional index (PNI) was calculated using albumin and lymphocyte value at the time of diagnosis. The relationship between PNI and overall survival was examined. Results: Of the 52 patients in our study, 47 were male and 5 were female. The median age was 62.9 years.The median PNI value was 45. Median progression-free survival was 6.9 months, median overall survival was 8.7 months. In the multivariate analysis, limited stage disease and PNI≥45 were found to be an independent good prognostic factor for overall survival. There was no relationship between overall survival and gender, age, and LDH status.

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