Kronik Obstrüktif Akciğer Hastalığı Hastalarındaki İşitme Sisteminin Değerlendirilmesi

Amaç: Bu çalışmada, kronik hipokseminin kronik obstrüktif akciğer hastalığı (KOAH) hastalarında işitsel işlevler üzerindeki etkisini incelemeyi amaçladık. Gereç ve Yöntem: Çalışmaya solunum fonksiyon testi (SFT) yapılan ve KOAH tanısı alan 60 hasta dahil edildi. Çalışmada dört çalışma grubu ve bir kontrol grubu oluşturulmuştur. Her çalışma grubu zorlu ekspiratuvar hacim (FEV1) ve FEV1/zorlu vital kapasite (FVC) oranına göre belirlendi. Gruplar hafif, orta, şiddetli ve çok şiddetli KOAH hastalarından oluşuyordu. Her grup 15 hastayı içeriyordu. Kontrol grubu FEV1/FVC oranı >%70 olan 30 hastadan oluşuyordu. Tüm hastalara saf ton odyometri ve otoakustik emisyon (OAE) testi uygulandı. Bulgular: Odyolojik değerlendirmeye göre şiddetli ve çok şiddetli grup ile kontrol grubu arasında istatistiksel olarak anlamlı farklılık bulundu (p

Evaluation of the Hearing System in Chronic Obstructive Pulmonary Disease Patients

Aim: This study aimed to examine the effect of chronic hypoxemia on auditory functions in chronic obstructive pulmonary disease (COPD) patients.Materials and Methods: Sixty patients who had pulmonary function test (PFT) and diagnosed with COPD were included in the study. Four studygroups and a control group were created in the study. Each study group was determined based on forced expiratory volume (FEV1) and FEV1/forcedvital capacity (FVC) ratio. Groups consisted of mild, moderate, severe and very severe COPD patients. Each group included 15 patients. The controlgroup consisted of 30 patients with an FEV1/FVC ratio of >70%. All patients underwent pure tone audiometry and otoacoustic emission (OAE) test.Results: According to the audiological evaluation, a statistically significant difference was found between the severe and very severe group andthe control group (p

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  • 1. Barberà JA, Roca J, Ferrer A, Félez MA, Díaz O, Roger N, et al. Mechanisms of worsening gas exchange during acute exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 1997;10:1285-91.
  • 2. Mazurek B, Haupt H, Georgiewa P, Klapp BF, Reisshauer A. A model of peripherally developing hearing loss and tinnitus based on the role of hypoxia and ischemia. Med Hypotheses. 2006;67:892-9.
  • 3. Carlile S, Bascom DA, Paterson DJ. The effect of acute hypoxia on the latency of the human auditory brainstem evoked response. Acta Otolaryngol. 1992;112:939-45.
  • 4. Johnston MV. Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury. Ann Neurol. 1983;13:511-8.
  • 5. Atkeson A, Jelic S. Mechanisms of endothelial dysfunction in obstructive sleep apnea. Vasc Health Risk Manag. 2008;4:1327-35.
  • 6. Schwarz EI, Puhan MA, Schlatzer C, Stradling JR, Kohler M. Effect of CPAP therapy on endothelial function in obstructive sleep apnoea: A systematic review and meta-analysis. Respirology. 2015;20:889-95.
  • 7. Papandreou C. Levels of TBARS are inversely associated with lowest oxygen saturation in obese patients with OSAS. Sleep Breath. 2013;17:1319-22.
  • 8. Niewoehner DE, Sobonya RE. Structure-function correlations in chronic airflow obstruction. Baum GL, Wolinsky E, (Eds). Textbook of Pulmonary Diseases, Little, Brown and Company, Boston. 1989;p.913.
  • 9. Baty F, Putora PM, Isenring B, Blum T, Brutsche M. Comorbidities and burden of COPD: a population based case-control study. PLoS One. 2013;8:e63285.
  • 10. Incalzi RA, Gemma A, Marra C, Capparella O, Fuso L, Carbonin P. Verbal memory impairment in COPD: its mechanisms and clinical relevance. Chest. 1997;112:1506-13.
  • 11. Sevenoaks MJ, Stockley RA. Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype? Respir Res. 2006;7:70.
  • 12. Wouters EF, Groenewegen KH, Dentener MA, Vernooy JH. Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations. Proc Am Thorac Soc. 2007;4:626-34.
  • 13. El-Kady MA, Durrant JD, Tawfik S, Abdel-Ghany S, Moussa AM. Study of auditory function in patients with chronic obstructive pulmonary diseases. Hear Res. 2006;212:109-16.
  • 14. Atiş S, Ozge A, Sevim S. The brainstem auditory evoked potential abnormalities in severe chronic obstructive pulmonary disease. Respirology. 2001;6:225-9.
  • 15. Gafni M, Sohmer H. Intermediate endocochlear potential levels induced by hypoxia. Acta Otolaryngol. 1976;82:354-8.
  • 16. Perlman HB, Kımura R, Fernandez C. Experiments on temporary obstruction of the internal auditory artery. Laryngoscope. 1959;69:591-613.
  • 17. Prazma J, Fischer ND, Biggers WP, Ascher D. A correlation of the effects of normoxia, hyperoxia and anoxia on PO2 of endolymph and cochlear potentials. Hear Res. 1978;1:3-9.
  • 18. Rebillard G, Lavigne-Rebillard M. Effect of reversible hypoxia on the compared time courses of endocochlear potential and 2f1-f2 distortion products. Hear Res. 1992;62:142-8.
  • 19. Rebillard G, Klis JF, Lavigne-Rebillard M, Devaux P, Puel JL, Pujol R. Changes in 2f1-f2 distortion product otoacoustic emissions following alterations of cochlear metabolism. Br J Audiol. 1993;27:117-21.
  • 20. Lucertini M, Ciniglio Appiani G, Antonini R, Urbani L. Effects of hypobaric hypoxia on the middle-latency and steady-state auditory evoked potentials. Audiology. 1993;32:356-62.
  • 21. Lamprecht B, McBurnie MA, Vollmer WM, Gudmundsson G, Welte T, Nizankowska-Mogilnicka E, et al. COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest. 2011;139:752-63.
Namık Kemal Tıp Dergisi-Cover
  • ISSN: 2587-0262
  • Yayın Aralığı: 4
  • Başlangıç: 2013
  • Yayıncı: Galenos Yayınevi
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