Figen DORAN, Hüsnü SÖNMEZ, İsa Burak GÜNEY, Kivilcim Eren ERDOĞAN, Gamze TUĞRUL

GASTROİNTESTİNAL VE PANKREATİK NÖROENDOKRİN TÜMÖRLERDE SOMATOSTATİN RESEPTÖRLERİNİN ÖNEMİ

Amaç: Nöroendokrin tümörler heterojen bir grup tümördür. Çoğu gastrointestinal ve pankreatik nöroendokrin tümör (GEPNET) düşük dereceli olmasına rağmen agresif davranış gösterir. Somatostatin reseptörleri GEPNET'de patogenezde yer alan ve tedavide hedef teşkil eden moleküllerdir. Çalışmamızda GEPNET vakalarında somatostatin reseptörü (SSTR) 2, 3 ve 5'in tümörlerin klinikopatolojik verileri eşliğinde korelasyonunu araştırmak amaçlanmıştır.Materyal ve Metot: Çalışmada 61 vakanın patolojik spesmenlerine somatostatin reseptörleri immüno-histokimyasal olarak uygulanmıştır.Bulgular: Olguların çoğu düşük dereceli olup, %23 olguda metastaz mevcuttur. SSTR2 %73 oranında pozitif boyanırken, SSTR3'te %47, SSTR5'te % 26 pozitif boyanma saptanmıştır. Olguların histolojik dereceleri arttıkça boyanma yüzdelerinde düşüş mevcuttur. Metastatik tümörlerde ise SSTR2'de pozitif boyanma oranı, metastatik olmayan olgulara göre daha düşüktür.Sonuç: Sonuçta somatostatin reseptörleri, olguların klinik gidişini tahmin etmede faydalı olabileceği gibi hedef tedavide de yer almaktadır.

UTILITY OF SOMATOSTATIN RECEPTORS IN GASTROINTESTINAL TRACT AND PANCREAS NEUROENDOCRINE TUMORS

Aim: Neuroendocrine tumors (NETs) are heterogenous group of tumors. Most of gastroenteropancreatic NETs (GEPNETs) are welldifferentiated low-grade tumors but a subset of them displays aggressive behavior. Somatostatin receptors (SSTR) play an im-portant role in the pathogenesis of GEPNETs, and they display targets for therapy. We aimed to evaluate SSTR2, SSTR3, SSTR5 byimmunohistochemistry in GEPNETs and correlate with clinicopathological findings.Materials and Methods: Totally 61 cases were enrolled into this study and evaluated for SSTR2, 3, and 5 by im-munohistochemically.Results: Mostly the patients had low-grade neoplasms and 23% of them had metastatic disease. Total-ly, 73%, 47%, and 26% positivity were found by SSTR2, SSTR3, and SSTR5, respectively. The histopathological grade was increased relative to decreasing expression levels of SSTRs. Among metastatic neoplasms, SSTR2 positivity was found to be greater than a non-metastatic disease.Conclusion: In conclusion, SSTRs are useful to predict the clinical outcomes as well as target of therapy.

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