Merve Deniz KÖSE, Şeyma GÜMÜŞ IŞIK, Oguz BAYRAKTAR

ZEYTİN YAPRAĞI POLİFENOLLERİ YÜKLÜ MUKOADHESİF ORAL FİLMLER

İlaç aktarım sistemleri arasında, ağızda çözünen filmler (AÇF'ler) birçok avantajı olan bir ilaç uygulama şeklidir. Yutma gerektiren geleneksel ilaç verme yöntemleri ile özellikle pediatrik ve geriatrik hastalarda bazı sorunlar yaşanabilir. Bu gibi durumlarda, ilacın ağızda dağılmış bir filmle verilmesi büyük kolaylık sağlar. Bu çalışmada, filmlerin hazırlanması için solvent döküm yöntemi tercih edilmiştir. Biyopolimer oranı ve yüklenmiş zeytin yaprağı ekstraktının film özellikleri üzerindeki etkisi, merkezi kompozit deneysel tasarım ile araştırılmıştır. Hazırlanan filmlerin karakterizasyon çalışmaları AFM, SEM ve FTIR analizleri ile yapılmıştır. Karakterizasyon çalışmalarına dayanarak, en iyi dört formülasyon seçilmiş ve araştırmada bu formülasyonlara odaklanılmıştır. Formülasyon 8, esneklik ve homojenlik gibi daha iyi film özellikleri, daha düşük parçalanma süresi (200 s) ve daha yüksek antioksidan kapasitesi (3.21 mM TEAC/g AÇF) nedeniyle 17 formülasyon arasından optimum formülasyon olarak seçilmiştir. Elde edilen veriler, hazırlanan ağızda çözünen filmlerle zeytin yaprağı polifenollerinin aktarımının mümkün olduğunu ortaya koymuştur.

Anahtar Kelimeler:

Ağızda Çözünen Film, Oral Film, Karboksimetil Kitosan, Bamya Zamkı, Zeytin Yaprağı Ekstraktı

OLIVE LEAF POLYPHENOLS LOADED MUCOADHESIVE ORAL FILMS

Among drug delivery systems, mouth dissolving films (MDFs) are a form of drug administration with many advantages. Some problems could be experienced, primarily in pediatric and geriatric patients with conventional drug delivery methods as swallowing. It is of great convenience to dispensing the drug with a film dispersed in the mouth in such cases. In this study, for the preparation of films, the solvent casting method was preferred. The effect of biopolymer ratio and loaded olive leaf extract on the film properties were investigated with the central composite experimental design. Characterization studies of the prepared films were done with AFM, SEM, and FTIR analysis. Based on the characterization studies, the four best formulations were chosen, and further investigations were focused on these formulations. Formulation 8 was chosen as the optimum formulation among 17 formulations due to its better film properties as flexibility and homogeneity, lower disintegration time 200s, and a higher antioxidant capacity 3.21 mM TEAC/g MDF. The obtained data revealed that it is possible to deliver olive leaf polyphenols with the prepared mouth dissolving films.

Keywords:

Mouth Dissolving Film, Oral Film, Carboxymethyl Chitosan, Okra Gum, Olive Leaf Extract,

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