Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

Objectives: Several studies demonstrate the relationship between coronary artery disease and inflammatory parameters. Nevertheless, there is paucity of data regarding the role of high sensitivity (hs)-C-reactive protein (CRP) to albumin ratio (CAR) in patients with ischemia on gated single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). This study was aimed at demonstrating the relationship between CAR and the occurrence of ischemia on gated SPECT MPI. Methods: We retrospectively evaluated 2.048 referred patients for gated SPECT MPI from a cardiology outpatient clinic between October 2017 and June 2019. After applying exclusion criteria and measuring serum CRP and albumin levels, we included 126 patients in the study. We then classified subjects into different groups according to the absence or presence of ischemia on gated SPECT MPI. Results: According to laboratory findings, hs-CRP and CAR were significantly higher in the ischemia group, while the serum albumin was significantly lower in ischemia group (p

C-reaktif Protein/Albümin Oranının Miyokardiyal Perfüzyon Sintigrafisinde İskemi Öngörmedeki Rolü

Amaç: Birçok çalışmada, koroner arter hastalığı ile enflamatuvar parametreler arasında ilişki bulunduğu gösterilmiştir. Bununla birlikte, tek foton emisyon tomografisi (SPECT) miyokard perfüzyon görüntülemesinde (MPI) iskemi bulunan hastalardaki C-reaktif proteinin (CRP)/albümin oranının (CAR) rolü ile ilgili yeterli veri bulunmamaktadır. Bu çalışmada, SPECT MPI’da CAR ve iskemi varlığı arasındaki ilişkiyi araştırmayı amaçladık. Yöntem: Ekim 2017 ve Haziran 2019 tarihleri arasında kardiyoloji polikliniğinden yönlendirilerek SPECT MPI yapılan 2,048 hasta retrospektif olarak değerlendirildi. Tarama popülasyonu değerlendirildiğinde serum CRP ve albümin düzeyleri ölçülen ve dışlama ölçütlerini karşılamayan 126 hasta çalışma grubunu oluşturdu. SPECT MPI’da iskemi varlığı ve yokluğuna göre hastalar iki gruba ayrılarak veriler değerlendirildi. Bulgular: Laboratuvar bulguları açısından değerlendirildiğinde iskemi bulunan grupta CRP ve CAR anlamlı olarak daha yüksek iken, bu grupta serum albümini anlamlı olarak daha düşük bulundu (her biri için p

Kaynakça

1. Doukky R, Frogge N, Balakrishnan G, Hayes K, Collado FM, Rangel MO, Golzar Y, Garcia-Sayan E, Hendel RC. The prognostic value of cardiac SPECT performed at the primary care physician’s office. J Nucl Cardiol 2013;20:519-528.

2. Hachamovitch R, Berman DS, Kiat H, Cohen I, Cabico JA, Friedman J, Diamond GA. Exercise myocardial perfusion SPECT in patients without known coronary artery disease: Incremental prognostic value and use in risk stratification. Circulation 1996;93:905-914.

3. Hosseinsabet A, Mohebbi A, Almasi A. C-reactive protein and Coronary Calcium Score association in coronary artery disease. Cardiol J 2008;15:431-436.

4. Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006;97;993-996.

5. Blaha MJ, Budoff MJ, DeFilippis AP, Blankstein R, Rivera JJ, Agatston A, O’Leary DH, Lima J, Blumenthal RS, Nasir K. Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: Implications for the JUPITER population from MESA, a population-based cohort study. Lancet 2011;378:684-692.

6. Redberg RF, Rifai N, Gee L, Ridker PM. Lack of association of C-reactive protein and coronary calcium by electron beam computed tomography in postmenopausal women: Implications for coronary artery disease screening. J Am Coll Cardiol 2000;36:39-43.

7. Wang W, Ren D, Wang CS, Li T, Yao HC, Ma SJ. Prognostic efficacy of high-sensitivity C-reactive protein to albumin ratio in patients with acute coronary syndrome. Biomark Med 2019;13:811-820.

8. Duman H, Çinier G, Bakırcı EM, Duman H, Şimşek Z, Hamur H, Değirmenci H, Emlek N. Relationship Between C-Reactive Protein to Albumin Ratio and Thrombus Burden in Patients With Acute Coronary Syndrome. Clin Appl Thromb Hemost 2019;25:1076029618824418.

9. Karabağ Y, Çağdaş M, Rencuzogullari I, Karakoyun S, Artaç İ, İliş D, Atalay E, Yesin M, Gürsoy MO, Halil Tanboğa I. Relationship between C-reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris. J Clin Lab Anal 2018;32:e22457.

10. Mahabadi AA, Möhlenkamp S, Moebus S, Dragano N, Kälsch H, Bauer M, Jöckel K-H, Erbel R, Heinz Nixdorf Investigator Group. The heinz nixdorf recall study and its potential impact on the adoption of atherosclerosis imaging in European primary prevention guidelines. Curr Atheroscler Rep 2011;13:367-372.

11. Malik S, Zhao Y, Budoff M, Nasir K, Blumenthal RS, Bertoni AG, Wong ND. Coronary artery calcium score for long-term risk classification in individuals with type 2 diabetes and metabolic syndrome from the multiethnic study of atherosclerosis. JAMA Cardiol 2017;2:1332-1340.

12. Dong Y, Wang X, Zhang L, Chen Z, Zheng C, Wang J, Kang Y, Shao L,Tian Y, Wang Z, China CVD study investigators. High-sensitivity C reactive protein and risk of cardiovascular disease in China-CVD study. J Epidemiol Community Health 2019;73:188-192.

13. Bisoendial RJ, Boekholdt SM, Vergeer M, Stroes ES, Kastelein JJ. C-reactive protein is a mediator of cardiovascular disease. Eur Heart J 2010;31:2087-2091.

14. Paoletti R, Bolego C, Poli A, Cignarella A. Metabolic Syndrome, Inflammation and Atherosclerosis. Vasc Health Risk Manag 2006;2:145- 152.

15. Morrow DA, Rifai N, Antman EM, Weiner DL, McCabe CH, Cannon CP, Braunwald E. C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy. Thrombolysis in Myocardial Infarction. J Am Coll Cardiol 1998;31:1460-1465.

16. Sabatine MS, Morrow DA, Jablonski KA, Rice MM, Warnica JW, Domanski MJ, Hsia J, Gersh BJ, Rifai N, Ridker PM, Pfeffer MA, Braunwald E, PEACE Investigators. Prognostic significance of the Centers for Disease Control/ American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease. Circulation 2007;115:1528-1536.

17. Askin L, Tanriverdi O, Tibili H, Turkmen S. Prognostic value of C-reactive protein / albumin ratio in ST-segment elevation myocardial infarction. Interventional Medicine and Applied Science 2019:1-4.

18. McMillan DC, Watson WS, O’Gorman P, Preston T, Scott HR, McArdle CS. Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss. Nutrition and cancer 2001;39:210-213.

19. Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med 2018;52:8-12.

20. Tamhane UU, Aneja S, Montgomery D, Rogers E-K, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008;102;653-657.

21. Azab B. Medhat Zaher, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, Gobunsuy R, Jadonath S, Baldari D, McCord D, Lafferty J. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106;470-476.

22. Park JJ, Jang HJ, Oh IY, Yoon CH, Suh JW, Cho YS, Youn TJ, Cho GY, Chae IH,Choi DJ. Prognostic value of neutrophil to lymphocyte ratio in patients presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol 2013;111;636-642.

23. Tanriverdi Z, Gungoren F, Tascanov MB, Besli F, Altiparmak IH. Comparing the Diagnostic Value of the C-Reactive Protein to Albumin Ratio With Other Inflammatory Markers in Patients With Stable Angina Pectoris. Angiology 2020;71:360-365

24. Rashidinejad H, Moazanzadeh M, Mirshekarpoor H, Ebrahim F. The relationship between HS-CRP serum levels with the results of cardiac perfusion SPECT imaging in patients with suspected coronary artery disease. Asian Journal of Biomedical and Pharmaceutical Sciences 2015;5:30-33.

Kaynak Göster

Molecular Imaging and Radionuclide Therapy
  • ISSN: 2146-1414
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1992

1.1b341

Sayıdaki Diğer Makaleler

Red Marrow Absorbed Dose Calculation in Thyroid Cancer Patient Using a Simplified Excel Spreadsheet

Rangsee SONGPRAKHON, Krisana ROYSRİ, Putthiporn CHAROENPHUN, Krisanat CHUAMSAAMARKKEE

The Role of Ga-68 PSMA PET/CT Scan on Differentiating of Oligometastatic and High Risk Prostate Cancer

Mehmet ERDOGAN, Emine Elif ÖZKAN, Sefa Alperen ÖZTÜRK, Mustafa YILDIZ, Sevim Süreyya SENGUL

Lung Perfusion Imaging with Technetium-99m Macroaggregated Albumin should be Combined with Contrast-enhanced Echocardiography for the Diagnosis of Hepatopulmonary Syndrome

Georgios MERİSTOUDİS, Georgia KERAMİDA, Ioannis ILİAS

Unforeseen COVID-19 on Oncologic Bone Scan with SPECT/CT in a High Prevalence Area

Sana Munir GİLL, Aamna HASSAN, Humayun BASHİR

Mickey Mouse Sign on Bone Scan in the Monostotic Form of Paget’s Disease Mimicking Osseous Metastasis

Selin KESİM, Halil Turgut TUROĞLU, Salih ÖZGÜVEN, Tunç ÖNDEŞ, Tanju Yusuf ERDİL

Comparative Findings Between 68Ga-PSMA and 18F-FDG PET/CT for Hepatocellular Carcinoma

Seval ERHAMAMCI, Nesrin ASLAN

Collimator and Energy Window Evaluation in Ga-67 Imaging by Monte Carlo Simulation

Mina OUAHMAN, Rachid ERRİFAİ, Hicham ASMİ, Youssef BOUZEKRAOUİ, Sanae DOUAMA, Farida BENTAYEB, Faustino BONUTTİ

Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

Süleyman Çağan EFE, Özlem Özdemir CANDAN, Cihan GÜNDOĞAN, Ahmet ÖZ, Yasin YÜKSEL, Burak AYÇA, Tevfik Fikret ÇERMİK

A Review of the History of Radioactive Iodine Theranostics: The Origin of Nuclear Ontology

John Dennis EHRHARDT, Seza GÜLEÇ

Metabolic Characterization of Anterior Mediastinal Masses by 18F-FDG PET/CT

Zehra Pınar KOÇ, Pelin ÖZCAN KARA, Erhan AYAN, Rabia BOZDOĞAN ARPACI