0.05). İlaçlar serum lipid düzeylerine etkileri yönünden birbirleriyle karşılaştırıldı. Betaksolol ile TK ve HDL kolesterol düzeylerinde karteolole göre anlamlı yükseklik bulunurken (p=0.02) TK/HDL oranında iki ilaç arasında anlamlı bir fark bulunmadı (p>0.05). SONUÇ: Betaksolol kullanımı ile serum HDL kolesterol seviyesi, karteolole göre anlamlı olarak yüksek bulunmasına rağmen, ateroskleroz ve koroner kalp hastalığı için en önemli lipid parametresi olarak kabul edilen TK/HDL oranı dikkate alındığında, selektif beta-1 blokajın, ISA'ye üstünlüğü görülmemiştir PURPOSE: To compare the effects of carteolol 2%, a nonselective betablocker with intrinsic sympathomimetic activity (ISA), with betaxolol 0.5%, a beta-1 selective betablocker, on serum lipoprotein cholesterol levels. MATERIAL AND METHODS: Carteolol 2% was applied twice daily, to 20 patients with ocular hypertension and normolipidemia for 2 months. After one month of drug free period the same patients were then given betaxolol 0.5 % twice daily for two months. Serum total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, VLDL cholesterol, and total to HDL cholesterol ratios were assessed before treatment, at the end of second month, after drug free period and at the end of the fifth month. Data were analyzed using t test in dependent groups and Wilcoxon signed ranks tests. RESULTS: There was no significant difference on serum lipoprotein levels with the use of each drug (p>0.05). Two drugs were compared with each other for their effects on serum lipoprotein levels. Total and HDL cholesterol levels were significantly higher with betaxalol use (p=0.02), whereas there was no significant difference, in terms of total to HDL cholesterol ratios (p>0.05). CONCLUSION: Although serum HDL cholesterol levels were significantly higher with betaxolol use, compared to carteolol use, when total to HDL cholesterol ratio is considered, which is the most important lipid parameter for atherosclerosis and coronary heart disease, selective beta 1 blockage was not found to be superior to ISA.">
[PDF] % 0.5 betaksolol ve % 2 karteolol' ün serum lipoprotein düzeylerine etkileri | [PDF] Effects of betaxolol and carteolol on serum lipoprotein levels
0.05). İlaçlar serum lipid düzeylerine etkileri yönünden birbirleriyle karşılaştırıldı. Betaksolol ile TK ve HDL kolesterol düzeylerinde karteolole göre anlamlı yükseklik bulunurken (p=0.02) TK/HDL oranında iki ilaç arasında anlamlı bir fark bulunmadı (p>0.05). SONUÇ: Betaksolol kullanımı ile serum HDL kolesterol seviyesi, karteolole göre anlamlı olarak yüksek bulunmasına rağmen, ateroskleroz ve koroner kalp hastalığı için en önemli lipid parametresi olarak kabul edilen TK/HDL oranı dikkate alındığında, selektif beta-1 blokajın, ISA'ye üstünlüğü görülmemiştir">
0.05). İlaçlar serum lipid düzeylerine etkileri yönünden birbirleriyle karşılaştırıldı. Betaksolol ile TK ve HDL kolesterol düzeylerinde karteolole göre anlamlı yükseklik bulunurken (p=0.02) TK/HDL oranında iki ilaç arasında anlamlı bir fark bulunmadı (p>0.05). SONUÇ: Betaksolol kullanımı ile serum HDL kolesterol seviyesi, karteolole göre anlamlı olarak yüksek bulunmasına rağmen, ateroskleroz ve koroner kalp hastalığı için en önemli lipid parametresi olarak kabul edilen TK/HDL oranı dikkate alındığında, selektif beta-1 blokajın, ISA'ye üstünlüğü görülmemiştir PURPOSE: To compare the effects of carteolol 2%, a nonselective betablocker with intrinsic sympathomimetic activity (ISA), with betaxolol 0.5%, a beta-1 selective betablocker, on serum lipoprotein cholesterol levels. MATERIAL AND METHODS: Carteolol 2% was applied twice daily, to 20 patients with ocular hypertension and normolipidemia for 2 months. After one month of drug free period the same patients were then given betaxolol 0.5 % twice daily for two months. Serum total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, VLDL cholesterol, and total to HDL cholesterol ratios were assessed before treatment, at the end of second month, after drug free period and at the end of the fifth month. Data were analyzed using t test in dependent groups and Wilcoxon signed ranks tests. RESULTS: There was no significant difference on serum lipoprotein levels with the use of each drug (p>0.05). Two drugs were compared with each other for their effects on serum lipoprotein levels. Total and HDL cholesterol levels were significantly higher with betaxalol use (p=0.02), whereas there was no significant difference, in terms of total to HDL cholesterol ratios (p>0.05). CONCLUSION: Although serum HDL cholesterol levels were significantly higher with betaxolol use, compared to carteolol use, when total to HDL cholesterol ratio is considered, which is the most important lipid parameter for atherosclerosis and coronary heart disease, selective beta 1 blockage was not found to be superior to ISA.">
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