Oral liken planus ile 25(OH) D vitamini arasindaki ilişki

Amaç: Oral liken planus hastalarında serum 25(OH) Vitamin D seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25(OH) Vitamin D seviyeleri ile oral liken planus arasında olası bir ilişki olup olmadığını belirlemektir. Yöntem: Ekim 2017- Mart 2018 tarihleri arasında oral liken planus tanısı konulan 25 hasta ve 83 sağlıklı birey çalışmaya alındı. Her iki grubun serum D vitamini seviyeleri yüksek performans likit kromatografi yöntemi ile değerlendirildi. Ayrıca serum paratiroid hormon, kalsiyum, fosfor, alkalen fosfataz seviyeleri de incelendi. Bulgular: Çalışmamıza 12- 53 yaş (ort 27.56 ± 6.8) arasındaki 25 hasta ve kontrol grubunda 18- 58 yaş arası (ort 34.38 ± 7.3) 83 sağlıklı birey katılmıştır. Oral liken planuslu hastalarda serum 25(OH) Vitamin D seviyeleri ortalama 21.23 ng / ml (7.34- 60.8 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25(OH) Vitamin D seviyeleri ortalama 23.4 ng / ml (3- 69.2 ng / ml) olarak belirlendi. Her iki grup arasında serum D vitamini düzeyleri arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05 ). Sonuç: Bu sonuçlara göre serum 25(OH) D vitamini ile oral liken planus arasında herhangi bir ilişki bulunmamıştır.

Anahtar Kelimeler:

oral liken planus, D vitamini, Serum

Association between oral licken planus and 25(OH) vitamin D

Aim: To evaluate serum 25-hydroxyvitamin D (25 (OH) D) levels in oral lichen planus patients and to determine whether there is a possible relationship between serum 25 (OH) D levels and oral lichen planus by comparing it with a control group of healthy individuals. Methods: 25 patients with oral lichen planus and 83 healthy individuals diagnosed between October 2017 and March 2018 were included in the study. Serum vitamin D levels of the study group were evaluated by high performance liquid chromatography method. Serum parathyroid hormone calcium, phosphorus, alkaline phosphatase levels were also examined. Results: 25 patients between 12- 53 years old(mean 27.56± 6.8) and 83 healthy individuals between 18-58 years old(mean: 34.38 ± 7.3) in the control group participated in our study. Serum 25 (OH) D levels were determined as an average of 21.23 ng / ml (7.34- 60.8 ng / ml) in patients with oral lichen planus. In the control group, serum 25 (OH) D levels were determined to be 23.4 ng / ml (3-69.2 ng / ml). There was no statistically significant difference between the serum vitamin D levels between the two groups(p> 0.05 ). Conclusion: According to these results, no relationship was found between oral lichen planus and serum 25 (OH) vitamin D.

Keywords:

Oral lichen planus, 25(OH) vitamin D, serum,

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