The prognostic factors for pregnancy after gonadotropin-induced controlled ovarian stimulation therapy with intrauterine insemination cycles

To identify the predictive determinants for pregnancy in patients who underwent controlled ovarian stimulation (COS) /intrauterine insemination (IUI). A total 458 gonadotropin-induced controlled ovarian stimulation and intrauterine insemination cycles in 361 couples using were studied between February 2014 and January 2018. The main outcome was clinical pregnancy rate, which has been analyzed according to baseline clinical characteristics (women age, length of infertility, day 3. follicle stimulating hormone, estradiol level) and variables related to intrauterine insemination cycle (number of preovulatory follicles, endometrial thickness), and sperm parameters (sperm concentration, sperm motility, sperm morphology and total motile sperm count (TMSC). The overall clinical pregnancy rate was 11.6% (53/458) per cycle. Clinical pregnancy rate per cycle was 12.0% (43/361) in the first cycle; 10.3% (9/87) in the second cycle, and 10% (1/10) in the third cycle. Among the predictive factors evaluated, more than 25x106 TMSC was also good predictor for clinical pregnancy. The TMSC in ejaculate proved to be a useful predictor of the chance for pregnancy after IUI treatment.

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