Prebiotics and Their Effects on Human Health

Bazı yiyeceklerin sağlık kalitelerini artırdıkları ve bazı sık görülen kanser formlarının oluşumunu önleyebileceği bilinmektedir. Başta gelişmiş ülkeler olmak üzere tüm dünya çapında bu beslenme problemlerini çözmek için yoğun araştırmalar yapılmakta ve eğitim programları düzenlenmektedir. Vücutta konak ve intestinal mikrobial popülasyonda bir denge durumu vardır ve bu dengeyi bozan sebepler hastalıklara sebep olurlar. Sağlıklı ve dengeli beslenme adına, fonksiyonel besinlerin diyete sokularak, diyetle ilişkili artmış hastalık riskinin azaltılması hedeflenmektedir. Bu fonksiyonel besinlerden bir tanesi de prebiyotiklerdir. Bu derlemede, prebiyotikler ve sağlığımız üzerindeki olumlu etkileri ele alınmıştır.

[Prebiyotikler ve İnsan Sağlığı Üzerindeki Etkileri]

It is known that some foods improve health quality and prevent the formation of some common forms of cancer. To solve this nutrition problem, intensive researches are performing and training programs are organizing in all over the world especially in the developed countries. There is a balance between host and intestinal microbiota in the body and the causes which disrupt this equilibrium cause diseases. For a healthy and balanced diet, reducing the risk of diet related diseases are targeted by adding functional foods to diet. One of the functional foods is prebiotics. In this review, we aimed to describe the beneficial effects of prebiotics on human health

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Jeromson S, Gallagher IJ, Galloway SD, Hamilton DL. Omega-3 Fatty Acids and Skeletal Muscle Health. Mar Drugs. 2015;13(11):6977-7004.

Lee HS. Impact of maternal diet on the epigenome during in utero life and the developmental programming of diseases in childhood and adulthood. Nutrients. 2015;7(11):9492-507.

Cardoso SM, Pereira OR, Seca AM, Pinto DC, Silva AM. Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods. Mar Drugs. 2015;13(11):6838-65.

Casari I, Falasca M. Diet and pancreatic cancer prevention. Cancers (Basel). 2015;7(4):2309-17.

Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787-803.

Hullar MA, Fu BC. Diet, the gut microbiome, and epigenetics. Cancer J. 2014;20(3):170-5.

Greiner AK, Papineni RV, Umar S. Chemoprevention in gastrointestinal physiology and disease. Natural products and microbiome. Am J Physiol Gastrointest Liver Physiol. 2014;307(1):G1-15.

Richter CK, Skulas-Ray AC, Champagne CM, Kris-Etherton PM. Plant protein and animal proteins: do they differentially affect cardiovascular disease risk? Adv Nutr. 2015;6(6):674-93.

Poppitt SD. Beverage consumption: are alcoholic and sugary drinks tipping the balance towards overweight and obesity? Nutrients. 2015;7(8):6700-18.

Pandey KR, Naik SR, Vakil BV. Probiotics, prebiotics and synbiotics- a review. J Food Sci Technol. 2015;52(12):7577-87.

Khorasani AC, Shojaosadati SA. Bacterial nanocellulose-pectin bionanocomposites as prebiotics against drying and gastrointestinal condition. Int J Biol Macromol. 2015;83:9-18.

Martinez RC, Bedani R, Saad SM. Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges. Br J Nutr. 2015;114(12):1993-2015.

Di Bartolomeo F, Startek JB, Van den Ende W. Prebiotics to fight diseases: reality or fiction? Phytother Res. 2013;27(10):1457-73.

Scartoni D, Desideri I, Giacomelli I, DI Cataldo V, DI Brina L, Mancuso A, Furfaro I, Bonomo P, Simontacchi G, Livi L. Nutritional supplement based on zinc, prebiotics, probiotics and vitamins to prevent radiation-related gastrointestinal disorders. Anticancer Res. 2015;35(10):5687-92.

Spiller R. Review article: probiotics and prebiotics in irritable bowel syndrome. Aliment Pharmacol Ther. 2008;28(4):385-96.

Bruno-Barcena JM, Azcarate-Peril MA. Galacto-oligosaccharides and colorectal cancer: feeding our intestinal probiome. J Funct Foods. 2015;12:92-108.

Serban DE. Gastrointestinal cancers: influence of gut microbiota, probiotics and prebiotics. Cancer Lett. 2014;345(2):258-70.

Gibson GR, Fuller R. Aspects of in vitro and in vivo research approaches directed toward identifying probiotics andprebiotics for human use. J Nutr. 2000;130(2S Suppl):391S-5S.

Tuohy KM, Probert HM, Smejkal CW, Gibson GR. Using probiotics and prebiotics to improve gut health. Drug Discov Today. 2003;8(15):692-700.

Samanta AK, Jayapal N, Senani S, Kolte AP, Sridhar M. Prebiotic inulin: Useful dietary adjuncts to manipulate the livestock gut microflora. Braz J Microbiol. 2013;44(1):1-14.

Guarner F, Casellas F, Borruel N, Antolín M, Videla S, Vilaseca J, Malagelada JR. Role of microecology in chronic inflammatory bowel diseases.Eur J Clin Nutr. 2002;56(Suppl 4):S34-8.

van Loo J, Coussement P, de Leenheer L, Hoebregs H, Smits G. On the presence of inulin and oligofructose as natural ingredients in the western diet. Crit Rev Food Sci Nutr. 1995;35(6):525-52.

Cherbut C. Inulin and oligofructose in the dietary fibre concept. Br J Nutr. 2002;87(Suppl 2):S159-62.

Flamm G, Glinsmann W, Kritchevsky D, Prosky L, Roberfroid M. Inulin and oligofructose as dietary fiber: a review of the evidence. Crit Rev Food Sci Nutr. 2001;41(5):353-62.

Coudray C, Bellanger J, Castiglia-Delavaud C, Remesy C, Vermorel V, Rayssignur Y. Effects of soluble or partly soluble dietary fibers supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur J Clin Nutr. 1997;51:375-80.

Remesy C, Behr SR, Levrat MA, Demigne C. Fibre fermentability in the rat caecum and its physiological consequence. Nutr Rev. 1992;12:1235-44.

Rowland IR, Rummney CJ, Coutts JT, Lievense LC. Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis. 1998;19:281-5.

Remesy C, Levrat MA, Gamet L, Demigne C. Faecal fermentation in rats fed oligosaccharides (inulin) are modulated by dietary calcium level. Am J Physiol. 1993;264:855-62.

Levrat MA, Remesy C, Demigne C. High propionate acid fermentation and mineral accumulation in the caecum adapted to different levels of inulin. J Nutr. 1991;121:1730-7.

Luo J, Rizkalla SW, Alamovitch C, Boussairi A, Blayo A. Chronic consumption of short chain fructooligosaccharides by health subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism. Am J Clin Nutr. 1996;63:639-45.

Kawaguchi M, Tashiro Y, Adachi T, Tamura Z. Changes on intestinal condition, fecal micro flora and composition of rectal gas after administration of fructooligosaccharide and lactulose at different dose. Bifidobacteria micro flora. 1993;13:57-68.

Bouhnik Y, Flourie B, D'Agay-Abensour L, Pochart P, Gramet G, Durand M, Rambaud JC. Administration of transgalacto-oligosaccharidesincreases faecal Bifidobacteria and modifies colonic fermantation metabolism in healthy humans. J Nutr. 1997;127:444-8.

Cummings JH, Macfarlane GT, Eneglyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73(2 Suppl):415S-20S.

Briet F, Achour L, Flourie B, Beaugerie L, Pellier P, Franchisseur C. Symptomatic response to varying levels of fructooligosaccharides consumed occasionally or regularly. Eur J Clin Nutr. 1995;49:501-7.

DuPont AW, Jiang ZD, Harold SA, Snyder N, Galler GW, Garcia-Torres F, DuPont HL. Motility abnormalities in irritable bowel syndrome. Digestion. 2014;89(2):119- 23.

Hidaka H, Tashiro Y, Eida T. Proliferation of Bifidobacteria by oligosaccharides and their useful effect on human health. Bifidobacteria micro flora. 1991;10:65-79.

Kleessen B, Sykura B, Zunft HJ, Blaut M. Effects of inulin and lactose on faecal micro flora, microbial activity and bowel habit in elderly constipated persons. Am J Clin Nutr. 1997;65:1397-402.

Gibson GR, Wang X. Regulatory effects of Bifidobacteria on the growth of the other colonic bacteria. J Appl Bacteriol. 1994;77:412-20.

Hond ED, Geypens B, Ghoos Y. Effect of high performance chicory inulin on constipation. Nutr Res. 2000;20:731-6.

Underwood MA, German JB, Lebrilla CB, Mills DA. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatr Res. 2015;77(1- 2):229-35.

Gibson GR, Beatty ER, Wang W, Cummings JH. Selective stimulation of Bifidobacteria Gastroenterology.1995;108:975-82. the human colon by oligofructose and inulin.

Ito M, Deguchi Y, Miyomati A, Matsumoto K, Kikuchi Y. Effects of administration of galactooligosaccharides on the human faecal micro flora, stool weight and abdominal sensation. Microbial Ecol Health Dis. 1990;3:285-92.

Costabile A, Kolida S, Klinder A, Giet E, Bäuerlein M, Frohberg C, Landschütze V, Gibson GR. A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects. Br J Nutr. 2010;104(7):1007-17.

Hidaka H, Eida T, Takizana T, Tokunaga T, Toshiro Y. Effect of fructo- oligosaccharides on intestinal flora and human health. Bifidobacteria micro flora. 1986;5:37-50.

Mitsou EK, Turunen K, Anapliotis P, Zisi D, Spiliotis V, Kyriacou A. Impact of a jelly containing short-chain fructo-oligosaccharides and Sideritis euboea extract on human faecal microbiota. Int J Food Microbioli. 2009;135(2):112-7.

Williams C, Witherly S, Buddington R. Influence of dietary neosugar on selected bacterial groups of the fecal microbiota. Microb Ecol Health Dis. 1993;7:91-7.

Bouhnik Y, Vahedi K, Achour L, Attan A, Salfati J. Short chain fructooligosaccharides administration dose dependently increases fecal Bifidobacteria in healthy humans. J Nutr. 1999;129:113-6.

Reading S, Aramendi S, Gibson G, Mc Cartney D. An in vitro investigation of prebiotic effect. Profibre, Lisbon, Portugal, 1998.

Intanon M, Arreola SL, Pham NH, Kneifel W, Haltrich D, Nguyen TH. Nature and biosynthesis of galacto-oligosaccharides related to oligosaccharides in human breast milk. FEMS Microbiol Lett. 2014;353(2):89-97.

Deguchi Y, Matsumoto K, Watanuki M. Effects of ?1-4 galacto-oligosaccharides administration on defecation of health volunteers with constipation tendency. Japanese J Nutr. 1997;55:13-22.

Narimiya M, Yokoi K, Tajima N, Sakai O, Ikade Y, Tahayama H. The effect of ?1-4 galactooligosaccharides on fecal flora in non insulin dependent diabetic patients with constipation. Japanese J Clin Nutr. 1996;18:44-50.

Tanaka R, Takayama, H, Morotomi M, Kuroshima T, Ueyama S, Matsumoto, K, Kurodo A, Mutai, M. Effects of administration of TOS and Bifdobacterium breve 4006 on the human faecal flora. Bifidobacteria micro flora. 1983;2:17-24.

Jackson KG, Taylor GRJ, Clohessey AM, Williams CM. The effect of daily intake of inulin and fasting lipid insulin and glucose concentration in middle aged men and women. Br J Nutr. 1999;82:23-30.

Achour L, Flourie B, Briet F, Pellier P, Marteau P, Rambaud JC. Gastrointestinal effects and energy value of polydextrose in healthy non-obese men. Am J Clin Nutr. 1994;59:1362-8.

Akdevelioğlu Y. What Are the Prebiotics and What are not. TAF Prev Med Bull. 2013;12(6):735-42.

Jie Z, Bang-yao L, Ming-jie X, Hai-wei L. Studies on the effect of polydextrose intake on physiologic functions in Chinese people. Am J Clin Nutr. 2000;72:6:1503- 9.

Denno DM, VanBuskirk K, Nelson ZC, Musser CA, Hay Burgess DC, Tarr PI. Use of the lactulose to mannitol ratio to evaluate childhood environmental enteric dysfunction: a systematic review. Clin Infect Dis. 2014;59(Suppl 4):S213-9.

Carlin A, Justham D. A literature review of two laxatives: lactulose and polyethylene glycol. Br J Community Nurs. 2011;16(12):584,586,588-90.

Kohmoto T, Fukui F, Mitsuoka T. Dose-response test of isomaltooligosaccharides for increasing faecal Bifidobacteria. Agricultural and Biological Chemistry. 1991;55(8):2157-9.

Kaneko T, Kohmoto T, Kikuchi H, Shiota M, Lino H, Mitsuoka T. Effects of isomaltooligosaccharides with different degrees of polymerization on human faecal Bifidobacteria. Bioscience Biotechnology and Biochemistry. 1994;58:12:2288-90.

Crittenden RG, Playne MJ. Production, properties and applications of food-grade oligosaccharides. Trends in Food Science and Technology. 1996;7:353-61.