Genotype distribution in chronic hepatitis C, relationship of genotype with HCV RNA, alpha fetoprotein, alanine aminotransferase and liver fibrosis

In this study, the genotype distribution in chronic hepatitis C (CHC) and its relationship with alanine aminotransferase (ALT), alpha fetoprotein (AFP), HCV RNA and liver fibrosis were compared. HCV RNA was negative in 63 and positive in 69 CHC cases who applied to the infectious diseases outpatient clinic between May 2016 and June 2018 were included in the study. Demographic data, laboratory and pathology results of the cases were evaluated retrospectively. 76 of the cases were male, 56 of them were female. In HCV RNA positive cases, Serum ALT and AFP level were statistically significantly higher than negative ones (p: 0.04, p: 0.001). Of HCV RNA positive cases, genotype 1b in 42 (60.9%), 3a in 10 (14.5%), 1a in 8 (11.6%), 4d in 5 (7.2%), and 2b in 4 (5.8%) were found. There was no statistically significant difference between genotypes in terms of HCV RNA, ALT and fibrosis. AFP level was statistically significantly higher in genotype 1b than other genotypes. Consistent with studies, the most common genotype was 1b. One of the main results is that there is no significant relationship between genotype difference and ALT, AFP and HCV RNA and fibrosis in CHC cases. Therefore, although these parameters may play a role in chronicity and inflammation, they may not be sufficient in the evaluation of fibrosis. High level of AFP in genotype 1b compared to other genopes may be useful in determining prognosis. Such studies may be important in epidemiological evaluation of HCI’s and follow-up of genotype profile changes.

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