Effect of benidipine on experimental gastric ulcers in rats

Peptic ulcer has been reported to increase acid secretion and lead to oxidative stress. Benidipine is an antihypertensive drug with antioxidant properties. This study aims to investigate the effects of benidipine on indomethacin-induced gastric ulcers in rats. Four groups were designed in this study. Gastric ulcer was occurred with indomethacin in the first three groups. These groups were treated with famotidine, benidipine and distilled water respectively 5 minutes before indomethacin administration. The fourth group rats didn’t have gastric ulcer and they received only distilled water. Six hours after drug administration gastric tissue was extracted and macroscopic and biochemical examinations were performed. Damaged areas in the stomach of benidipine and famotidine receiving animal groups were smaller than the indomethacin received animals. Indomethacin elevated the levels of malondialdehyde and myeloperoxidase in the stomach tissue (p

___

Chan FK, Leung WK. Peptic-ulcer disease. Lancet. 2002;360:933-41.

Schwartz K. Beitrage űber penetrierende Magen und Jejunalgeschwűre. Klin Chir. 1910;57:96-128.

Sokic MA, Krstic M, Popovic D, et al. Role of Helicobacter pylori infection and use of NSAIDs in the etiopathogenesis of upper gastrointestinal bleeding. Acta Chir Iugosl. 2007;54:51-62.

Szabo S, Trier J, Brown A, et al. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology. 1985;88:228-36.

Aadland E, Berstad A. Effect of verapamil on gastric secretion in man. Scand J Gastroenterol. 1983;18:969-71.

Kato T. Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder. Cell Calcium. 2008;44:92-102.

Zavodnik IB, Dremza IK, Cheshchevik VT, et al. Oxidative damage of rat liver mitochondria during exposure to t-butyl hydroperoxide. Role of Ca2+ ions in oxidative processes. Life Sci. 2013;92:1110-7.

Itoh M, Guth PH. Role of oxygen-derived free radicals in hemorrhagic shockinduced gastric lesions in the rat. Gastroenterology. 1985;88:1162-7.

Salim A. Scavenging free radicals to prevent stress-induced gastric mucosal injury. Lancet. 1989;334:1390.

Naito Y, Yoshikawa T, Yoshida N, et al. Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig Diss Sci. 1998;43:30-4.

Sigthorsson G, Crane R, Simon T, et al. COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin. Gut. 2000;47:527-32.

Suleyman H, Albayrak A, Bilici M, et al. Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. Inflammation. 2010;33:224-34.

Suleyman H, Demircan B, Karagoz Y. Anti-inflammatory and side effects of cyclo-oxygenase inhibitors. Pharmacol Rep. 2007;59:247.

Piao X, Li S, Sui X, et al. 1-deoxynojirimycin (DNJ) ameliorates indomethacin-induced gastric ulcer in mice by affecting NF-kappaB signaling pathway. Front Pharmacol. 2018;9:372.

Albayrak A, Alp HH, Suleyman H. Investigation of antiulcer and antioxidant activity of moclobemide in rats. Eurasian J Med. 2015;47:32.

Polat B, Suleyman H, Alp HH. Adaptation of rat gastric tissue against indomethacin toxicity. Chem Biol Interact. 2010;186:82-9.

Saito I, Suzuki H, Kageyama S, et al. Effect of antihypertensive treatment on cardiovascular events in elderly hypertensive patients: Japan’s Benidipine Research on Antihypertensive Effects in the Elderly (J-BRAVE). Clin Exp Hypertens. 2011;33:133-40.

Hassan MQ, Akhtar MS, Akhtar M, et al. Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage. Ther Adv Cardiovasc Dis. 2016;10:214-23.

Ohtani K, Usui S, Kaneko S, et al. Benidipine reduces ischemia reperfusioninduced systemic oxidative stress through suppression of aldosterone production in mice. Hypertens Res. 2012;35:287.

Unlubilgin E, Suleyman B, Balci G, et al. Prevention of infertility induced by ovarian ischemia reperfusion injury by benidipine in rats: Biochemical, gene expression, histopathological and immunohistochemical evaluation. J Gynecol Obstet Hum Reprod. 2017;46:267-73.

Suleyman B, Halici Z, Odabasoglu F, Gocer F. The effect of Lacidipine on Indomethacin induced ulcer in rats. Int J Pharmacol. 2012;8:115-21.

Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-8.

Bradley PP, Priebat DA, Christensen RD, et al. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Investig Dermatol. 1982;78:206-9.

Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem. 1968;25:192-205.

Lawrence RA, Sunde RA, Schwartz GL, et al. Glutathione peroxidase activity in rat lens and other tissues in relation to dietary selenium intake. Exp Eye Res. 1974;18:563-9.

Carlberg I, Mannervik B. Glutathione reductase. Methods Enzymol. 1985;113:484-90.

Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases the f irst enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249:7130-9.

Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497-500.

Borekci B, Kumtepe Y, Karaca M, et al. Role of α-2 adrenergic receptors in anti-ulcer effect mechanism of estrogen and luteinising hormone on rats. Gynecol Endocrinol. 2009;25:264-8.

Dengiz GO, Odabasoglu F, Halici Z, et al. Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. Arch Pharm Res. 2007;30:1426-34.

Allam MM, El-Gohary OA. Gastroprotective effect of ghrelin against indomethacin-induced gastric injury in rats: possible role of heme oxygenase-1 pathway. Gen Physiol Biophys. 2017;36:321-30.

Gomaa AM, El-Mottaleb NAA, Aamer HA. Antioxidant and antiinflammatory activities of alpha lipoic acid protect against indomethacininduced gastric ulcer in rats. Biomed Pharmacother. 2018;101:188-94.

Polat B, Albayrak Y, Suleyman B, et al. Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats. Pharmacol Rep. 2011;63:518-26.

Asanuma H, Kitakaze M, Node K, et al. Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin-and NO-dependent mechanisms in canine hearts. Cardiovasc Drugs Ther. 2001;15:225-31.

Suleyman H. The role of alpha-2 adrenergic receptors in anti-ulcer activity. Eurasian J Med. 2012;44:43.

Suleyman H, Cadirci E, Albayrak A, et al. Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats. Chem Biol Interac. 2009;180:318-24.

Kisaoglu A, Borekci B, Yapca OE, et al. Tissue damage and oxidant/ antioxidant balance. Eurasian J Med. 2013;45:47.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Malaria prevalence and risk analysis among pregnant women in Bungoma county, Kenya

Wekesa Antony WANYONYİ, Chrispinus Siteti MULAMBALAH, David H. MULAMA, Elizabeth OMUKUNDA

Effect of alveolar recruitment maneuver on ischemia-modified albumin and oxidative stress in laparoscopic cholecystectomy

Zubeyir CEBECİ, Betül KOZANHAN, Hüseyin KURKU, Sadik OZMEN

Communication difficulties in perioperative anesthesia management for immigrant and refugee patients

Mehmet Akif YAZAR, Yasin TİRE, Betül KOZANHAN

Efficacy and safety of intravitreal aflibercept therapy in diabetic macular edema

Ali Cihat ASLAN, Serkan ERDENOZ, Akin CAKİR, Burak ERDEN, Çetin Akpolat, Mustafa ELCİOĞLU

Cause of rare acute abdomen: Primary omental torsion

Gulseren AKPİNAR, Bedia GULEN, ALİ DUMAN, Afsin IPEKCI, Hilal HOCAGİL

Olanzapine-induced bilateral pedal and pretibial edema: A case report

Behice HAN ALMİS, Mehmet Hamdi ÖRÜM

Is childhood trauma a predictive factor for increased preoperative anxiety levels?

Ayse VAHAPOGLU, Suna Medin NACAR, Yagmur Suadiye DALGİC, Hande GUNGOR

Effect of benidipine on experimental gastric ulcers in rats

Bahadir SULEYMAN, Renad MAMMADOV, Adalet OZCİCEK, Fatih OZCİCEK, Durdu ALTUNER, MEHMET KUZUCU, Zeynep SULEYMAN

Early treatment with esophageal stenting in trauma-induced esophageal perforation- a case report and literature review

Yasir Furkan CAGİN

Nutritional status of elderly people living in nursing home and some related factors

Recep BENTLİ, Neşe KARAKAŞ, Betul FİRİNCİ, Serdar DENİZ