Vaishnav J, Vaishnav G, Jolly VAİSHNAV, Gunvant VAİSHNAV

A Study of Feto-Maternal Outcome in Patients with Prelabour Rupture of Membranes at Term (>37 Weeks)

To determine the fetomaternal out come in patients with premature rupture of membrane after 37 completed weeks, but before onset of labour. Prospective case control study of 66 patients. Incidence of PROM was 8.09 % during study period, 1.79 % applicable for study. No correlation found between PROM and delivery interval and mode of delivery. No correlation between mode of delivery and gravida status and labour induced with Misoprostol or not. 54.5 % (36) induced with Misoprostol 25µg and more, 7 (10.61%) developed minor side effects, like nausea in 6 (9.09%) patients and vomiting and fever (100.2ºF), 5(7.58%) patient. No significant difference in mode of delivery in cases and control. Mean PROM-delivery interval 11.67 hrs in induced versus 8.05 hrs in spontaneous group. Hospital stay in cases was 6.87 days, is higher in study group compare to controls, mostly due to antibiotics given to baby, so mother was kept ward. Neonatal CRP is significantly higher around 30.30 % & almost all required antibiotics. 20 babies had CRP and 2 had raised total count in case group. Only 1 baby in the case with MBA, kept in NICU for observation for one day. These are not comparable due to small sample size in the study.

Keywords:

rupture of membranes, PROM, misoprostol,

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1. Dufff P, Huff RW, Gibbs RS. Management of premature rupture of membranes and unfavorable cervix in term pregnancy. Obstet Gynecol. 1984;63(5):697-702.
2. Wagner MV, Chin VP, Peters CJ, Drexler B, Newman LA. A comparison of early and delayed induction of labor with spontaneous rupture of membranes at term. Obstet Gynecol. 1989;74(1):93-7.
3. Vadillo Ortega F, Beltrán J, Mateo H, Monzón F. Phospholipase A2 and premature membrane rupture. Ginecol Obstet Mex. 1994;62:143-5.
4. Weiyuan Z, Li W. Study of interleukin-6 and tumor necrosis factor-alpha levels in maternal serum and amniotic fluid of patients with premature rupture of membranes. J Perinat Med. 1998;26(6):491-4.
5. Ozden S, Delikara MN, Avci A, Fiçicioglu C. Intravaginal misoprostol vs. expectant management in premature rupture of membranes with low Bishop scores at term. Int J Gynaecol Obstet. 2002;77(2):109-15.
6. Cunningham F, Leveno K, Bloom S, Hauth J, Gilstrap L, Wenstrom K. Preterm Birth. In: Williams Obstetrics: 22nd ed. McGraw Hill Companies, Inc.,USA, 2005; 139-41.
7. Arias F, Daftary SN, Bhide AG. Premature rupture of membranes. In: Practical guide to high risk pregnancy and delivery 3rd ed. Elsevier Health Sciences, 2008.
8. Rath DM, Manas K. Induction of labor with oral misoprostol in women with prelabor rupture of membranes at term. J Obstet Gynecol India. 2007;57(6):505-8.
9. Lin MG, Nuthalapaty FS, Carver AR, Case AS, Ramsey PS. Misoprostol for labor induction in women with term premature rupture of membranes: a meta-analysis. Obstet Gynecol. 2005;106(3):593-601.
10. Butt KD, Bennett KA, Crane JM, Hutchens D, Young DC. Randomized comparison of oral misoprostol and oxytocin for labor induction in term prelabor membrane rupture. Obstet Gynecol. 1999;94(6):994-9.