Uşak İlinde Çocuklarda Üriner Sistem Enfeksiyonlarının Mikrobiyolojik ve Antimikrobiyal Profili

Amaç: En yaygın pediatrik hastalıklardan biri, pediatrik popülasyondaki tüm enfeksiyonların %3’ünü oluşturan ve yedi yaşına kadar erkek çocukların %2’sini ve kız çocuklarının %8’ini etkileyen idrar yolu enfeksiyonudur (İYE). Bakteriler, vakaların yüzde 95’inden fazlasını oluşturan İYE’lerin en yaygın nedenidir. İYE’n de en sık izole eden bakteri Escherichia coli’dir. Antibiyotikler idrar yolu enfeksiyonların tedavisinin temelini oluşturur. Sonuç olarak, bakteriyel enfeksiyonların terapötik tedavisinde doğru antibiyotik duyarlılığının belirlenmesi kritik öneme sahiptir. Bu çalışmada Uşak’ta belirgin İYE semptomları ile başvuran çocuklarda idrar yolu enfeksiyonunun etiyolojisi ve antimikrobiyal direnç özelliklerinin incelenmesi amaçlanmıştır. Materyal ve Metot: Uşak Öztan Hastanesi’ne ayaktan idrar yolu enfeksiyonu semptom ve şikayetleri ile başvuran, 2018 Ocak-2020 Aralık ayları arasında idrar tahlili ve idrar kültürü alınan 0-16 yaş arası çocuk hastalardan toplam 1250 idrar kültürü sonucu retrospektif olarak incelendi. Bulgular: Çalışmamızda değerlendirilen 1250 pediyatrik hastanın 238’inde (%19) gram negatif mikroorganizma üremesi bulundu. 877 (%70) hastanın idrar kültüründe üreme olmadı. Çalışmamızda hastaların 168’inde (%70,5) E. coli en fazla izole edilen mikroorganizma E. coli idi. Sonuçlar: Uşak ili için ilk antimikrobiyal direnç verilerini sunuyoruz. Çalışmamız, mevcut yerel uygulamanın aksine, toplum kökenli İYE’lerin ampirik tedavisi için amoksisilin/klavulanatın en iyi seçenek olmadığını göstermiştir. Ayrıca çalışmamızda seftriakson en dirençli ikinci antibiyotik olarak bulundu.

Microbiological and Antimicrobial Profile of Urinary System Infections in Children in Uşak

Aim: One of the most prevalent pediatric diseases is urinary tract infection (UTI), accounting for 3% of all infections among the pediatric population and affect 2% of males and 8% of females by age seven. Bacteria are the most prevalent cause of UTIs, accounting for more than 95 percent of cases. The most prevalent causal bacteria of UTI is Escherichia coli. Antibiotics are included in the treatment of these infections. As a result, determining the correct antibiotic susceptibility is critical in the therapeutic treatment of bacterial infections. This study aimed to analyse the aetiology and antimicrobial resistance characteristics of urinary tract infection among children presenting with symptoms in Uşak. Material and Method: A total of 1250 urine culture results were retrospectively analyzed from pediatric patients aged 0–16 years who were admitted to Uşak Öztan Hospital as outpatients with symptoms and complaints of urinary tract infection and whose urine analysis and urine culture were taken between January 2018 and December 2020. Result: Gram-negative microorganism growth was found in 238 (19%) of the 1250 pediatric patients evaluated in our study. There was no growth in the urine cultures of 877 (70%) patients. E. coli was the most isolated microorganism in our study, which was detected in 168 (70.5%) of the patients. Conclusions: We present the first antimicrobial resistance data for the city of Uşak. Our study showed that amoxicillin/clavulanate is not the best option for the empirical therapy of community acquired UTIs, contrary to current local practice. In addition, ceftriaxone was found to be the second most resistant antibiotic in our study.

Keywords:

pediatrics, , urinary tract infecrions etiology, antibiotic resistansce,

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